concept

GLUT4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLUT4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

322Connections
0Hypotheses
1Analyses
50Outgoing
50Incoming

Summary

GLUT4 is a concept in neurodegeneration research. Key relationships include: activates, protects against, inhibits. Associated with AD, Aging, Als. Connected to 146 entities in the SciDEX knowledge graph.

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💡 Concept Info
NameGLUT4
Key Genes/ProteinsCYP2E1, NRF2, TUG, AMPK, AKT
Related DiseasesObesity, Alzheimer, Als, Neurodegeneration
Related PathwaysCholesterol
Linked Hypotheses1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

mechanism · 4869 words

CREB Signaling in Neurodegeneration

mechanism · 4156 words

metabolic-dysfunction-neurodegeneration

mechanism · 3868 words

FOXO1 Protein

protein · 3787 words

Pathway Diagram

graph TD
    GLUT4["GLUT4"]
    GLUT4 -->|"activates"| Diabetes["Diabetes"]
    GLUT4 -->|"activates"| Obesity["Obesity"]
    GLUT4 -->|"activates"| Neuroinflammation["Neuroinflammation"]
    GLUT4 -->|"activates"| Inflammation["Inflammation"]
    GLUT4 -->|"activates"| Aging["Aging"]
    GLUT4 -->|"activates"| Ms["Ms"]
    GLUT4 -->|"target for"| Stroke["Stroke"]
    GLUT4 -->|"activates"| Fibrosis["Fibrosis"]
    GLUT4 -->|"target for"| Neurodegeneration["Neurodegeneration"]
    GLUT4 -->|"activates"| Alzheimer["Alzheimer"]
    CYP2E1["CYP2E1"] -->|"inhibits"| GLUT4
    NRF2["NRF2"] -->|"inhibits"| GLUT4
    FGFR1["FGFR1"] -->|"activates"| GLUT4
    FGF21["FGF21"] -->|"activates"| GLUT4
    SOD2["SOD2"] -->|"activates"| GLUT4
    BACE1["BACE1"] -->|"activates"| GLUT4
    PI3K["PI3K"] -->|"activates"| GLUT4
    MTOR["MTOR"] -->|"inhibits"| GLUT4
    PLIN1["PLIN1"] -->|"activates"| GLUT4
    AND["AND"] -->|"activates"| GLUT4

Outgoing (211)

TargetRelationTypeStr
Brain Glucose Metabolisminvolved_inprocess0.90
Obesityactivatesdisease0.75
Alzheimeractivatesdisease0.75
Alsactivatesdisease0.75
Alsprotects_againstdisease0.75

Incoming (111)

SourceRelationTypeStr
TUGinteracts_withentity0.95
CYP2E1inhibitsprotein0.90
NRF2inhibitsprotein0.90
TUGbindsprotein0.90
h-075f1f02targets_genehypothesis0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Metabolic reprogramming in neurodegenerative disease

neurodegeneration | 2026-04-02 | 3 hypotheses Top: 0.398

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found