protein

TARDBP/TDP-43

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TARDBP/TDP-43: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

81Connections

0Hypotheses

0Analyses

36Outgoing

45Incoming

Summary

Neurodegeneration-related protein: TARDBP/TDP-43 Protein

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🔬 Protein Info

Gene Symbol	TARDBP/TDP-43
Amino Acids	414 aa
Pathways	Tdp-43, Chaperone, Unfolded Protein Response, Ubiquitin-Proteasome, UNFOLDED PROTEIN RESPONSE
Interactions	LAMP1, LGALS3, STUB1, PARKINSON, amyotrophic lateral sclerosis, HUNTINGTON
KG Connections	81 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    TARDBP_TDP_43["<b>TARDBP/TDP-43</b>"]
    LAMP1["LAMP1"]
    TARDBP_TDP_43 -->|"activates"| LAMP1
    Tdp_43["Tdp-43"]
    TARDBP_TDP_43 -->|"activates"| Tdp_43
    LGALS3["LGALS3"]
    TARDBP_TDP_43 -->|"activates"| LGALS3
    STUB1["STUB1"]
    TARDBP_TDP_43 -->|"activates"| STUB1
    PARKINSON["PARKINSON"]
    TARDBP_TDP_43 -->|"activates"| PARKINSON
    amyotrophic_lateral_sclerosis["amyotrophic lateral sclerosis"]
    TARDBP_TDP_43 -->|"activates"| amyotrophic_lateral_sclerosis
    HUNTINGTON["HUNTINGTON"]
    TARDBP_TDP_43 -->|"activates"| HUNTINGTON
    Neurodegenerative_Diseases["Neurodegenerative Diseases"]
    TARDBP_TDP_43 -->|"activates"| Neurodegenerative_Diseases
    Spinal_Cord["Spinal Cord"]
    TARDBP_TDP_43 -->|"activates"| Spinal_Cord
    Chaperone["Chaperone"]
    TARDBP_TDP_43 -->|"activates"| Chaperone
    disease["disease"]
    TARDBP_TDP_43 -->|"activates"| disease
    PPP3["PPP3"]
    TARDBP_TDP_43 -->|"activates"| PPP3
    Neuroblastoma["Neuroblastoma"]
    TARDBP_TDP_43 -->|"activates"| Neuroblastoma
    SELECTIVE_AUTOPHAGY["SELECTIVE AUTOPHAGY"]
    TARDBP_TDP_43 -->|"activates"| SELECTIVE_AUTOPHAGY
    STEM_CELLS["STEM CELLS"]
    TARDBP_TDP_43 -->|"activates"| STEM_CELLS
    RAPAMYCIN["RAPAMYCIN"]
    TARDBP_TDP_43 -->|"activates"| RAPAMYCIN
    PEROXISOME["PEROXISOME"]
    TARDBP_TDP_43 -->|"activates"| PEROXISOME
    UBIQUITIN["UBIQUITIN"]
    TARDBP_TDP_43 -->|"activates"| UBIQUITIN
    VALOSIN["VALOSIN"]
    TARDBP_TDP_43 -->|"activates"| VALOSIN
    DEMENTIA["DEMENTIA"]
    TARDBP_TDP_43 -->|"activates"| DEMENTIA
    MAP1LC3["MAP1LC3"]
    TARDBP_TDP_43 -->|"activates"| MAP1LC3
    PROTEASOME["PROTEASOME"]
    TARDBP_TDP_43 -->|"activates"| PROTEASOME
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    TARDBP_TDP_43 -->|"activates"| FRONTOTEMPORAL_DEMENTIA
    Unfolded_Protein_Response["Unfolded Protein Response"]
    TARDBP_TDP_43 -->|"activates"| Unfolded_Protein_Response
    Neuron["Neuron"]
    TARDBP_TDP_43 -->|"activates"| Neuron
    Stem_Cell["Stem Cell"]
    TARDBP_TDP_43 -->|"activates"| Stem_Cell
    Ubiquitin_Proteasome["Ubiquitin-Proteasome"]
    TARDBP_TDP_43 -->|"activates"| Ubiquitin_Proteasome
    FRONTOTEMPORAL["FRONTOTEMPORAL"]
    TARDBP_TDP_43 -->|"activates"| FRONTOTEMPORAL
    IPSC["IPSC"]
    TARDBP_TDP_43 -->|"activates"| IPSC
    TFEB["TFEB"]
    TFEB -->|"activates"| TARDBP_TDP_43

Outgoing (36)

Target	Relation	Type	Str
LAMP1	activates	protein	0.50
Tdp-43	activates	pathway	0.50
LGALS3	activates	gene	0.50
STUB1	activates	gene	0.50
PARKINSON	activates	gene	0.50
amyotrophic lateral sclerosis	activates	gene	0.50
HUNTINGTON	activates	gene	0.50
Neurodegenerative Diseases	activates	disease	0.50
Spinal Cord	activates	cell_type	0.50
Chaperone	activates	pathway	0.50
disease	activates	disease	0.50
PPP3	activates	concept	0.50
Neuroblastoma	activates	disease	0.50
SELECTIVE AUTOPHAGY	activates	concept	0.50
STEM CELLS	activates	concept	0.50
RAPAMYCIN	activates	concept	0.50
PEROXISOME	activates	concept	0.50
UBIQUITIN	activates	protein	0.50
VALOSIN	activates	gene	0.50
DEMENTIA	activates	gene	0.50
MAP1LC3	activates	gene	0.50
FRONTOTEMPORAL DEMENTIA	activates	disease	0.50
Unfolded Protein Response	activates	pathway	0.50
Neuron	activates	cell_type	0.50
Stem Cell	activates	cell_type	0.50
Ubiquitin-Proteasome	activates	pathway	0.50
FRONTOTEMPORAL	activates	concept	0.50
IPSC	activates	concept	0.50
TAR	co_discussed	protein	0.40
DNA	co_discussed	protein	0.40
TBK1	co_discussed	gene	0.40
TFEB	co_discussed	protein	0.40
UNFOLDED PROTEIN RESPONSE	co_discussed	pathway	0.40
UBIQUITIN-PROTEASOME	co_discussed	pathway	0.40
VCP	co_discussed	gene	0.40
VALOSIN	co_discussed	gene	0.40

Incoming (45)

Source	Relation	Type	Str
TFEB	activates	protein	0.50
Autophagy	activates	process	0.50
PPARGC1A	activates	gene	0.50
STIP1	activates	gene	0.50
TARDBP	activates	gene	0.50
BECN1	activates	gene	0.50
SQSTM1	activates	gene	0.50
mTOR	activates	entity	0.50
MAP1LC3B	activates	gene	0.50
MCOLN1	activates	gene	0.50
BAG3	activates	gene	0.50
TREH	activates	gene	0.50
GAPDH	activates	gene	0.50
HSPB8	activates	gene	0.50
Sod1	activates	gene	0.50
CTSB	activates	gene	0.50
PPP3CB	activates	gene	0.50
LAMP2A	activates	gene	0.50
BCL2	activates	gene	0.50
HSPA8	activates	gene	0.50
TPP1	activates	gene	0.50
PTEN	activates	gene	0.50
PINK1	activates	gene	0.50
TBK1	activates	gene	0.50
SPHK1	activates	gene	0.50
CHMP2B	activates	gene	0.50
NEURON	co_discussed	gene	0.40
AUTOPHAGY	co_discussed	process	0.40
ALS	co_discussed	disease	0.40
RELA	co_discussed	gene	0.40
NEURODEGENERATIVE DISEASES	co_discussed	disease	0.40
MYOT	co_discussed	gene	0.40
LATE	co_discussed	disease	0.40
ATG	co_discussed	gene	0.40
CHMP2B	co_discussed	gene	0.40
FTD	co_discussed	disease	0.40
FRONTOTEMPORAL DEMENTIA	co_discussed	disease	0.40
LC3	co_discussed	protein	0.40
ACTIN	co_discussed	protein	0.40
MAP1LC3	co_discussed	gene	0.40
MTOR	co_discussed	pathway	0.40
RAPAMYCIN	co_discussed	drug	0.40
PINK1	co_discussed	gene	0.40
PTEN	co_discussed	gene	0.40
SPHK1	co_discussed	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TARDBP/TDP-43

Understanding Entity Pages

Summary

Wiki Pages (20)

nimodipine-als

neuroinflammation

ftd-tdp-pathology

Mitochondrial Dysfunction in Neurodegeneration

Pre-symptomatic Conversion Windows in ALS Genetic Risk Carriers

RNA Metabolism Dysregulation in Alzheimer's Disease

Motor Neuron Disease (MND)

ALS-FTD Spectrum

ALS Pipeline

ALS Biomarker-to-Mechanism Mapping

ALS RNA Metabolism and Proteostasis Failure

Calcium Dysregulation in Neurodegenerative Diseases

Stress Granules in Neurodegeneration

SOD1 Superoxide Dismutase 1 ALS Causal Chain

SURF4 — SURF4 Homolog

Nucleocytoplasmic Transport Defects in Neurodegenerative Diseases

TREM2 in Amyotrophic Lateral Sclerosis

Antisense Oligonucleotide Therapy for Neurodegeneration