protein

ATF4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATF4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

565Connections

2Hypotheses

4Analyses

50Outgoing

50Incoming

0Experiments

4Debates

Summary

ATF4 is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, Aging, Als. Connected to 313 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	ATF4
Full Name	Activating Transcription Factor 4
Chromosome	22q13.1
Protein Type	Transcription Factor
Function	Amino acid metabolism: Upregulates genes involved in amino acid transport and synthesis
Molecular Weight	38.6 kDa
Pathways	Apoptosis, Autophagy, Epigenetic, Er Stress, Ferroptosis
UniProt ID	[P18848](https://www.uniprot.org/uniprot/P18848)
GeneCards	ATF4
Human Protein Atlas	ATF4
Associated Diseases	Aging, Atherosclerosis, cancer, Glioblastoma, Tumor
Known Drugs/Compounds	rapamycin
Interactions	ACSL4, Actin, AGING, AKT, AMPK, AMYLOID
SciDEX Hypotheses	ATF4-DDIT3 stress signaling indirectly represses M
KG Connections	565 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ATF4["ATF4"] -->|"regulates"| mitophagy["mitophagy"]
    ATF4["ATF4"] -->|"therapeutic target"| Ms["Ms"]
    ATF4["ATF4"] -->|"therapeutic target"| Als["Als"]
    ATF4["ATF4"] -->|"interacts"| Cancer["Cancer"]
    ATF4["ATF4"] -->|"interacts"| Aging["Aging"]
    ATF4["ATF4"] -->|"interacts"| Ms_1["Ms"]
    CXCL2["CXCL2"] -->|"therapeutic target"| ATF4["ATF4"]
    IL6["IL6"] -->|"therapeutic target"| ATF4["ATF4"]
    GABARAP["GABARAP"] -->|"associated"| ATF4["ATF4"]
    RANK["RANK"] -->|"regulates"| ATF4["ATF4"]
    style ATF4 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (357)

Target	Relation	Type	Str
Integrated Stress Response	regulates	pathway	0.88
Apoptosis	upregulates	process	0.88
Integrated Stress Response	mediates	pathway	0.85
Cell Death	promotes	phenotype	0.85
INTEGRATED STRESS RESPONSE	mediates	entity	0.85
Als	activates	disease	0.85
integrated stress response	promotes	pathway	0.85
Apoptosis	associated_with	process	0.85
Er Stress	activates	pathway	0.80
Als	regulates	disease	0.75
Endoplasmic Reticulum Stress	biomarker_for	process	0.75
Tumor	activates	disease	0.75
proteostasis	activates	process	0.70
DDIT3	activates	gene	0.70
MAPT	inhibits	gene	0.70
Mtor	activates	pathway	0.70
apoptosis pathway	participates_in	pathway	0.70
Mitophagy	activates	pathway	0.70
ACSL4	activates	protein	0.70
mitophagy	regulates	process	0.70
stress response pathways	activates	pathway	0.70
Ms	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Alzheimer	expressed_in	disease	0.65
Leukemia	regulates	disease	0.65
Cancer	interacts_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Aging	interacts_with	disease	0.65
Anxiety	expressed_in	disease	0.65
Tumor	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Als	interacts_with	disease	0.65
Heart Failure	therapeutic_target	disease	0.65
Aging	activates	disease	0.65
Cardiomyopathy	inhibits	disease	0.65
Diabetes	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Glaucoma	regulates	disease	0.65
Cancer	associated_with	disease	0.65
Glioma	activates	disease	0.65
Fibrosis	activates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Stroke	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Diabetes	activates	disease	0.65
Cardiac	inhibits	disease	0.65

Incoming (208)

Source	Relation	Type	Str
Identified Compounds	upregulates	compound	0.90
p38 MAPK	phosphorylates	protein	0.90
ER stress	activates	process	0.90
p38 MAPK	regulates	pathway	0.90
PERK	upregulates	protein	0.85
EFTUD2	regulates	gene	0.85
ATG2A-G433A	upregulates	variant	0.85
DTG	upregulates	drug	0.85
DDIT3	upregulates	gene	0.80
PERK	activates	gene	0.70
proteostatic_stress	activates	process	0.70
APOE4	inhibits	protein	0.70
MITOPHAGY	activates	gene	0.70
APOPTOSIS	activates	gene	0.70
BCL2	activates	gene	0.60
ERK1	activates	gene	0.60
CALCOCO2	expressed_in	gene	0.60
ATF3	activates	entity	0.60
PPP1R15A	activates	gene	0.60
HIPPO	regulates	gene	0.60
RUNX2	associated_with	gene	0.60
P53	activates	gene	0.60
CANCER	therapeutic_target	gene	0.60
PROTEIN MISFOLDING	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
MTORC1	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.60
AUTOPHAGY	activates	gene	0.60
BRAIN INJURY	activates	gene	0.60
RETREG1	activates	gene	0.60
GLIOBLASTOMA	associated_with	gene	0.60
STROKE	activates	gene	0.60
RNA	therapeutic_target	gene	0.60
BAX	activates	gene	0.60
AND	activates	gene	0.60
TFAM	activates	gene	0.60
IL23A	therapeutic_target	gene	0.60
FERROPTOSIS	activates	gene	0.60
CANCER	activates	gene	0.60
APOPTOSIS	regulates	gene	0.60
EFTUD2	activates	gene	0.60
CREB	activates	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
OCLN	therapeutic_target	gene	0.60
AGING	activates	gene	0.60
DIABETES MELLITUS	inhibits	gene	0.60
NEURODEGENERATION	activates	gene	0.60
AMPK	activates	gene	0.60
TRIB3	activates	gene	0.60
NF-ΚB	expressed_in	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ATF4-DDIT3 stress signaling indirectly represses MAPT transc	0.624	neurodegeneration	Which specific transcription factors med
eIF2alpha Dephosphorylation Threshold Prevents Pro-Apoptotic	0.445	-	What is the minimum effective dose of tr

Mentioning Analyses (4)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (4)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning ATF4 in their description or question text

No additional research found

ATF4

Understanding Entity Pages

Summary

Wiki Pages (3)

ATF4 Gene

Activating Transcription Factor 4 (ATF4)

ATF4 Protein

Pathway Diagram

Outgoing (357)

Incoming (208)

Targeting Hypotheses (2)

Mentioning Analyses (4)

Which specific transcription factors mediate MAPT suppression during proteostati

What determines the GPX4/ACSL4 balance that switches microglia from protective t

What molecular mechanism causes VCP mutations to trigger aberrant HIF-1α activat

What molecular mechanisms drive tissue-specific phenotypes in Mendelian neurolog

Experiments (0)

Related Papers (0)

Debates (4)

Which specific transcription factors mediate MAPT suppression during proteostati

While ACSL4-driven ferroptosis was strongly supported, the molecular triggers th

The study shows VCP-mutant astrocytes exhibit hypoxia response activation withou

The abstract identifies tissue-specific networks that may underlie Mendelian dis

Related Research