concept

CDH1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDH1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

505Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

CDH1 is a concept in neurodegeneration research. Key relationships include: interacts with, regulates, therapeutic target. Associated with ALS, Aging, Als. Connected to 387 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	CDH1
Key Genes/Proteins	APC/C(CDH1), FZR1, Anapc11, CMVS, APC
Related Diseases	Cancer, Als, Tumor, Carcinoma

Wiki Pages (16)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CDH1["CDH1"]
    CDH1 -->|"interacts"| Cancer["Cancer"]
    CDH1 -->|"regulates"| Fibrosis["Fibrosis"]
    CDH1 -->|"interacts"| Als["Als"]
    CDH1 -->|"interacts"| Ms["Ms"]
    CDH1 -->|"activates"| Aging["Aging"]
    CMVS["CMVS"] -->|"activates"| CDH1
    GABARAP["GABARAP"] -->|"interacts"| CDH1
    P38["P38"] -->|"interacts"| CDH1
    PIK3C3["PIK3C3"] -->|"interacts"| CDH1
    AKT1["AKT1"] -->|"regulates"| CDH1
    DDIT3["DDIT3"] -->|"interacts"| CDH1
    IFNG["IFNG"] -->|"interacts"| CDH1
    PI3K["PI3K"] -->|"interacts"| CDH1

Outgoing (293)

Target	Relation	Type	Str
APC/C(CDH1)	component_of	protein	0.95
Cancer	activates	disease	0.85
Anapc11	interacts_with	protein	0.85
Als	activates	disease	0.75
Cancer	associated_with	disease	0.75
Tumor	activates	disease	0.75
Carcinoma	activates	disease	0.75
Cancer	contributes_to	disease	0.75
Carcinoma	causes	disease	0.75
APC	regulates	gene	0.70
APC	activates	gene	0.70
CANCER	activates	gene	0.70
PI3K	regulates	pathway	0.70
AKT	regulates	pathway	0.70
beta-catenin	regulates	protein	0.70
Hippo	regulates	pathway	0.70
YAP	regulates	protein	0.70
TAZ	regulates	protein	0.70
Cancer	interacts_with	disease	0.65
Fibrosis	regulates	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Ms	activates	disease	0.65
Aging	activates	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
Cancer	inhibits	disease	0.65
Aging	regulates	disease	0.65
Ataxia	regulates	disease	0.65
Carcinoma	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Als	associated_with	disease	0.65
Cancer	expressed_in	disease	0.65
Carcinoma	regulates	disease	0.65
Als	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Tumor	regulates	disease	0.65
Heart Failure	associated_with	disease	0.65
Cancer	biomarker_for	disease	0.65
Carcinoma	biomarker_for	disease	0.65
Aging	associated_with	disease	0.65
Inflammation	interacts_with	disease	0.65

Incoming (212)

Source	Relation	Type	Str
Byf	upregulates	drug	0.95
FZR1	encodes	gene	0.95
Thermal Adaptation	upregulates	process	0.90
Thermal adaptation	upregulates	process	0.85
CMVS	activates	protein	0.72
CANCER	activates	gene	0.70
GABARAP	interacts_with	gene	0.60
P38	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
AKT1	regulates	gene	0.60
DDIT3	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
AMBRA1	regulates	gene	0.60
ATF6	regulates	gene	0.60
AMPK	regulates	gene	0.60
HSPA5	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
CASP3	regulates	gene	0.60
CGAS	regulates	gene	0.60
RB1	interacts_with	gene	0.60
ATG	regulates	gene	0.60
RPS6KB1	interacts_with	gene	0.60
JUN	activates	gene	0.60
AKK	activates	gene	0.60
CD4	activates	gene	0.60
HMOX1	activates	gene	0.60
OCLN	inhibits	gene	0.60
G6PD	protects_against	gene	0.60
SMAD3	activates	gene	0.60
FGF20	therapeutic_target	gene	0.60
BRG1	regulates	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	regulates	gene	0.60
CTNNB1	regulates	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
FOXM1	regulates	gene	0.60
LEF1	therapeutic_target	gene	0.60
SMARCA4	regulates	gene	0.60
TERT	therapeutic_target	gene	0.60
APC	activates	gene	0.60
AKK	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CDH1

Understanding Entity Pages

Summary

Wiki Pages (16)

TAZ (WWTR1)

pard3

LEF1

N-Cadherin (CDH2) Protein

CDKN1B — Cyclin-Dependent Kinase Inhibitor 1B

E-Cadherin (CDH1) Protein

ARHGAP26 — Rho GTPase Activating Protein 26

Sox2 Neurons

Mammillary Body Neurons

BRG1 Gene

CHEK2

CACNB3

JUP Protein

PCDH19 Alliance