concept

FKBP5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FKBP5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

469Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

FKBP5 is a concept in neurodegeneration research. Key relationships include: associated with, interacts with, inhibits. Associated with ALS, Aging, Als. Connected to 195 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	FKBP5
Key Genes/Proteins	NR3C1
Related Diseases	Emotional Aspects Of Tinnitus, Emotional Aspects of Tinnitus
Related Pathways	Hpa Axis, glucocorticoid signaling

🔮 Predicted Structure: FKBP5 — AlphaFold Q13451 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    FKBP5["FKBP5"]
    FKBP5 -->|"inhibits"| Ms["Ms"]
    FKBP5 -->|"regulates"| Inflammation["Inflammation"]
    FKBP5 -->|"regulates"| Alzheimer["Alzheimer"]
    FKBP5 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    FKBP5 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    FKBP5 -->|"target for"| Als["Als"]
    FKBP5 -->|"interacts"| HSPA1A["HSPA1A"]
    SKA2["SKA2"] -->|"interacts"| FKBP5
    HSPA1A -->|"interacts"| FKBP5
    HSP90AA1["HSP90AA1"] -->|"interacts"| FKBP5
    DNAJB1["DNAJB1"] -->|"interacts"| FKBP5
    FKBP4["FKBP4"] -->|"interacts"| FKBP5
    CRH["CRH"] -->|"interacts"| FKBP5
    IL18["IL18"] -->|"activates"| FKBP5
    RAMP1["RAMP1"] -->|"inhibits"| FKBP5
    CRHR1["CRHR1"] -->|"interacts"| FKBP5
    GENES["GENES"] -->|"interacts"| FKBP5

Outgoing (286)

Target	Relation	Type	Str
Hpa Axis	involved_in	pathway	0.90
Emotional Aspects Of Tinnitus	involved_in	phenotype	0.90
secretory autophagy	promotes	process	0.88
Secretory Autophagy	activates	process	0.85
Emotional Aspects of Tinnitus	contributes_to	phenotype	0.85
Emotional Aspects Of Tinnitus	contributes_to	phenotype	0.85
CeA	expressed_in	brain_region	0.80
PPAR-γ	regulates	transcription_factor	0.80
NR3C1	co_mentioned_with	gene	0.80
neural stem cells	activates	cell_type	0.80
glucocorticoid signaling	regulates	pathway	0.80
HSP90	co_chaperone	protein	0.80
Autophagy	regulates	pathway	0.70
neurons	activates	cell_type	0.70
neural stem cells	regulates	cell_type	0.70
Addiction	methylates	disease	0.65
Ptsd	inhibits	disease	0.65
Ptsd	associated_with	disease	0.65
Addiction	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Ms	inhibits	disease	0.65
Schizophrenia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Bipolar	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Ms	regulates	disease	0.65
Cancer	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
ALS	associated_with	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Aging	inhibits	disease	0.65
Huntington	inhibits	disease	0.65
Autoimmune	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Hypertension	associated_with	disease	0.65
Depression	methylates	disease	0.65
Cancer	regulates	disease	0.65
Als	regulates	disease	0.65
ALS	interacts_with	disease	0.65
Tumor	activates	disease	0.65
neurodegeneration	associated_with	disease	0.61

Incoming (183)

Source	Relation	Type	Str
Stress	upregulates	process	0.90
h-637a53c9	targets_gene	hypothesis	0.90
Familiar Context Stress	upregulates	process	0.85
Central Amygdala	expressed_in	cell_type	0.85
BDNF	co_mentioned_with	gene	0.80
SKA2	interacts_with	gene	0.64
HSPA1A	interacts_with	gene	0.61
HSP90AA1	interacts_with	gene	0.61
DNAJB1	interacts_with	gene	0.61
CRH	co_mentioned_with	gene	0.60
FKBP4	interacts_with	protein	0.60
BDNF	upregulates	entity	0.60
CRH	upregulates	entity	0.60
CRH	interacts_with	gene	0.60
IL18	activates	gene	0.60
RAMP1	inhibits	gene	0.60
HTR2A	associated_with	gene	0.60
DISC1	associated_with	gene	0.60
SGK1	associated_with	gene	0.60
CRHR1	interacts_with	gene	0.60
TNF	associated_with	gene	0.60
JUN	associated_with	gene	0.60
NR3C1	interacts_with	gene	0.60
CRHR1	inhibits	gene	0.60
CALCA	inhibits	gene	0.60
BDNF	activates	gene	0.60
NR3C1	inhibits	gene	0.60
BDNF	associated_with	gene	0.60
GRM4	associated_with	gene	0.60
TRPM2	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
GABRA5	associated_with	gene	0.60
GRM3	associated_with	gene	0.60
DAO	associated_with	gene	0.60
NRG1	associated_with	gene	0.60
GRIN2B	associated_with	gene	0.60
RGS4	associated_with	gene	0.60
NCAM1	associated_with	gene	0.60
POLG	associated_with	gene	0.60
CRH	activates	gene	0.60
NLRP3	regulates	gene	0.60
RAB7A	associated_with	gene	0.60
ARRB1	associated_with	gene	0.60
SLC6A4	expressed_in	gene	0.60
DICER1	expressed_in	gene	0.60
NR3C1	expressed_in	gene	0.60
IL1B	expressed_in	gene	0.60
AKT1	expressed_in	gene	0.60
COMT	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

APOE4 structural biology and therapeutic targeting strategies

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.595

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FKBP5

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Proteostasis Network Dysfunction Comparison Across Neurodegenerative Diseases

Glucocorticoid Signaling Pathway in Neurodegeneration

cortisol-tau-pathway

Hypothalamic-Pituitary-Adrenal Axis

proteostasis-triad-pulses

Section 102: Proteostasis Network Dysregulation in CBS/PSP

Proteostasis Therapy CBS PSP

Proteostasis Network in Neurodegeneration

Section 204: Advanced Proteostasis and Protein Quality Control in CBS/PSP

Proteostasis and ERAD Pathway in Neurodegeneration

Proteostasis Triad Pulses: ISR + Autophagy + Chaperone Induction

Stress Response in Neurodegeneration

Stress Granule Formation in Neurodegeneration

Section 117: Long-Term Disease Modification Endpoints for CBS/PSP

A2M Gene

Stress Granule-Associated Neurons