concept

TCR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TCR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

337Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

TCR is a concept in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with AD, ALI, ALS. Connected to 153 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	TCR
Key Genes/Proteins	AMBRA1, PI3K, INFLAMMATION
Related Diseases	Inflammation, Autoimmune, Als, Cancer, ALS
Related Pathways	oxidative stress response

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    TCR["TCR"]
    TCR -->|"regulates"| AMBRA1["AMBRA1"]
    TCR -->|"expressed in"| Autoimmune["Autoimmune"]
    TCR -->|"expressed in"| Cancer["Cancer"]
    TCR -->|"activates"| ALS["ALS"]
    TCR -->|"regulates"| Inflammation["Inflammation"]
    TCR -->|"regulates"| Heart_Failure["Heart Failure"]
    TCR -->|"activates"| CD40["CD40"]
    TCR -->|"expressed in"| CANCER["CANCER"]
    ERBB3["ERBB3"] -->|"contributes to"| TCR
    CD4["CD4"] -->|"interacts"| TCR
    AND["AND"] -->|"expressed in"| TCR
    CD40 -->|"activates"| TCR
    APP["APP"] -->|"contributes to"| TCR
    EGFR["EGFR"] -->|"contributes to"| TCR
    FOXP3["FOXP3"] -->|"regulates"| TCR

Outgoing (221)

Target	Relation	Type	Str
Inflammation	activates	disease	0.95
T cell activation	mediates	process	0.95
AMBRA1	regulates	protein	0.90
T cells	expressed_in	cell_type	0.90
Autoimmune	activates	disease	0.85
oxidative stress response	participates_in	pathway	0.80
Als	activates	disease	0.75
PI3K	activates	gene	0.70
INFLAMMATION	activates	gene	0.70
Autoimmune	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Cancer	associated_with	disease	0.65
ALS	activates	disease	0.65
Inflammation	regulates	disease	0.65
Heart Failure	regulates	disease	0.65
ALS	expressed_in	disease	0.65
Tumor	associated_with	disease	0.65
Cancer	biomarker_for	disease	0.65
Neurodegeneration	activates	disease	0.65
Ms	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Leukemia	activates	disease	0.65
Lymphoma	activates	disease	0.65
Tumor	biomarker_for	disease	0.65
Als	expressed_in	disease	0.65
Lymphoma	biomarker_for	disease	0.65
Tumor	activates	disease	0.65
Autoimmune	contributes_to	disease	0.65
Infection	activates	disease	0.65
Autoimmune	interacts_with	disease	0.65
Inflammation	causes	disease	0.65
Autoimmune	causes	disease	0.65
Ms	therapeutic_target	disease	0.65
Autoimmune	therapeutic_target	disease	0.65
Cancer	inhibits	disease	0.65
Ms	expressed_in	disease	0.65
Aging	activates	disease	0.65
Parkinson	activates	disease	0.65
Necroptosis	inhibits	disease	0.65
Cancer	activates	disease	0.65
Tumor	inhibits	disease	0.65
Inflammation	interacts_with	disease	0.65
Encephalitis	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65

Incoming (116)

Source	Relation	Type	Str
KCNMA1	associated_with	gene	0.60
KCNQ1	associated_with	gene	0.60
PIEZO1	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
HIPPO	associated_with	gene	0.60
CFTR	associated_with	gene	0.60
SCN1A	associated_with	gene	0.60
TRPA1	associated_with	gene	0.60
KCNN4	associated_with	gene	0.60
AXON	associated_with	gene	0.60
PIEZO2	associated_with	gene	0.60
SCN5A	associated_with	gene	0.60
TRPV4	associated_with	gene	0.60
SCNN1A	associated_with	gene	0.60
TRPV1	associated_with	gene	0.60
KCNK2	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
ERBB3	contributes_to	gene	0.60
CD4	interacts_with	gene	0.60
CD4	associated_with	gene	0.60
CD8	associated_with	gene	0.60
CD40	activates	gene	0.60
APP	contributes_to	gene	0.60
EGFR	contributes_to	gene	0.60
FOXP3	regulates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ACSL4	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
FYN	activates	gene	0.60
LCK	activates	gene	0.60
PIK3C3	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
BECN1	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
MIRNAS	activates	gene	0.60
PTEN	activates	gene	0.60
TNF	activates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
TXNIP	biomarker_for	gene	0.60
AND	biomarker_for	gene	0.60
IL7R	biomarker_for	gene	0.60
CD4	activates	gene	0.60
CD8	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
AND	interacts_with	gene	0.60
CD4	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	0.60
OVERVIEW	inhibits	gene	0.60
AND	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TCR

Understanding Entity Pages

Summary

Wiki Pages (20)

NF-κB Signaling Pathway in Neurodegeneration

RASGRP1 Gene

PILRA Gene

treg-regulatory-t-cell-therapy-parkinsons

SIGLEC10 — Sialic Acid Binding Ig-Like Lectin 10

Lateral Hypothalamus

CD81

LCK Protein (Lymphocyte-Specific Protein Tyrosine Kinase)

FOXP3 (Forkhead Box P3)

Gene Page: ALS4 (SENATAXIN)

SRC Protein (SRC Proto-Oncogene)

STAT4 Gene

Neuroinflammation in PD

GTF2H6

sk4-protein

SEL1L Protein

IKBKG Gene

AMBRA1 Gene