concept

ENDOSOMES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ENDOSOMES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

544Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

ENDOSOMES is a concept in neurodegeneration research. Key relationships include: activates, interacts with, expressed in. Associated with ALS, Aging, Als. Connected to 253 entities in the SciDEX knowledge graph.

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💡 Concept Info
NameENDOSOMES
Key Genes/ProteinsC9ORF72, EGF
Related DiseasesAtaxia, Als, ALS, Neurodegeneration, Ms

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

Parkinson's Disease

disease · 8807 words

Alzheimer's Disease Mechanism Index

mechanism · 5834 words

Pathway Diagram

graph TD
    ENDOSOMES["ENDOSOMES"]
    ENDOSOMES -->|"expressed in"| Neurodegeneration["Neurodegeneration"]
    ENDOSOMES -->|"expressed in"| Als["Als"]
    ENDOSOMES -->|"expressed in"| Ms["Ms"]
    ENDOSOMES -->|"expressed in"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ENDOSOMES -->|"expressed in"| Dementia["Dementia"]
    ENDOSOMES -->|"activates"| Tumor["Tumor"]
    ENDOSOMES -->|"regulates"| Aging["Aging"]
    C9ORF72["C9ORF72"] -->|"binds"| ENDOSOMES
    ATM["ATM"] -->|"expressed in"| ENDOSOMES
    NEURODEGENERATION["NEURODEGENERATION"] -->|"expressed in"| ENDOSOMES
    MOTOR_NEURONS["MOTOR NEURONS"] -->|"interacts"| ENDOSOMES
    VESICLE_TRAFFICKING["VESICLE TRAFFICKING"] -->|"interacts"| ENDOSOMES
    LYSOSOMAL_BIOGENESIS["LYSOSOMAL BIOGENESIS"] -->|"interacts"| ENDOSOMES
    C9ORF72_REPEAT_EXPANSION["C9ORF72 REPEAT EXPANSION"] -->|"expressed in"| ENDOSOMES
    CHMP2B["CHMP2B"] -->|"expressed in"| ENDOSOMES
    OPTN["OPTN"] -->|"expressed in"| ENDOSOMES

Outgoing (318)

TargetRelationTypeStr
Ataxiaassociated_withdisease0.75
Alsinteracts_withdisease0.75
ALScausesdisease0.75
EGFactivatesgene0.70
Neurodegenerationexpressed_indisease0.65

Incoming (226)

SourceRelationTypeStr
C9ORF72bindsgene0.90
C9ORF72interacts_withgene0.74
NEURODEGENERATIONexpressed_ingene0.60
MOTOR NEURONSinteracts_withgene0.60
VESICLE TRAFFICKINGinteracts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found