concept

IL-4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL-4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

321Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	IL-4
Key Genes/Proteins	ARRB1, ARRB2
Related Diseases	Pain, Tumor, Neuroinflammation, Inflammation, Parkinson

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    IL_4["IL-4"]
    style IL_4 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    IL_4 -->|"activates"| Microglia_Reactivity["Microglia Reactivity"]
    IL_4 -.->|"prevents"| senescence["senescence"]
    IL_4 -->|"regulates"| ARRB1([ARRB1])
    IL_4 -->|"regulates"| ARRB2([ARRB2])
    IL_4 -->|"activates"| INFLAMMATION["INFLAMMATION"]
    IL_4 -->|"regulates"| Pain["Pain"]
    IL_4 -->|"regulates"| Tumor["Tumor"]
    IL_4 -->|"activates"| Neuroinflammation["Neuroinflammation"]
    IL_4 -->|"activates"| Inflammation["Inflammation"]
    IL_4 -->|"activates"| Parkinson["Parkinson"]
    TNF([TNF]) -->|"regulates"| IL_4
    NF__B(["NF-KappaB"]) -->|"activates"| IL_4
    IL_6([IL-6]) -->|"activates"| IL_4
    JNK([JNK]) -->|"activates"| IL_4
    P38([P38]) -->|"activates"| IL_4
    PARKINSON([PARKINSON]) -->|"activates"| IL_4
    NEUROINFLAMMATION([NEUROINFLAMMATION]) -->|"activates"| IL_4
    ALZHEIMER([ALZHEIMER]) -->|"target for"| IL_4
    APOPTOSIS([APOPTOSIS]) -->|"target for"| IL_4
    NLRP3([NLRP3]) -->|"target for"| IL_4

Outgoing (192)

Target	Relation	Type	Str
Microglia Reactivity	activates	process	0.95
senescence	prevents	process	0.95
ARRB1	regulates	gene	0.85
ARRB2	regulates	gene	0.85
M2 Microglial Polarization	mediates	process	0.85
Pain	regulates	disease	0.65
Tumor	regulates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Parkinson	activates	disease	0.65
Ms	activates	disease	0.65
Tumor	activates	disease	0.65
Als	activates	disease	0.65
Parkinson	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Dementia	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
ALS	inhibits	disease	0.65
ALS	activates	disease	0.65
Als	inhibits	disease	0.65
Aging	protects_against	disease	0.65
Senescence	therapeutic_target	disease	0.65
Alzheimer	activates	disease	0.65
Stroke	activates	disease	0.65
Als	regulates	disease	0.65
Multiple Sclerosis	biomarker_for	disease	0.65
Senescence	biomarker_for	disease	0.65
Vascular Dementia	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
Dementia	inhibits	disease	0.65
Stroke	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Senescence	protects_against	disease	0.65
Cancer	associated_with	disease	0.65
Vascular Dementia	therapeutic_target	disease	0.65
AND	regulates	gene	0.60
IL-10	regulates	gene	0.60
CYTOKINES	regulates	gene	0.60
IFN	regulates	gene	0.60
Immune Response	regulates	pathway	0.60

Incoming (129)

Source	Relation	Type	Str
PNS-R1	downregulates	compound	0.85
ALZHEIMER'S DISEASE	associated_with	disease	0.64
TNF	regulates	gene	0.60
NF-ΚB	activates	gene	0.60
IL-6	activates	gene	0.60
JNK	activates	gene	0.60
P38	activates	gene	0.60
PARKINSON	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
NLRP3	therapeutic_target	gene	0.60
TNF	activates	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
ALS	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
ASC	therapeutic_target	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
CLDN1	inhibits	gene	0.60
ARNT	activates	gene	0.60
AHR	activates	gene	0.60
NRF2	activates	gene	0.60
STAT6	activates	gene	0.60
PARKINSON	regulates	gene	0.60
ROS	activates	gene	0.60
CLDN4	expressed_in	gene	0.60
MICROGLIA	activates	gene	0.60
STROKE	therapeutic_target	gene	0.60
IL-1	activates	gene	0.60
DNA	activates	gene	0.60
STAT6	protects_against	gene	0.60
IL-22	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
IRF7	inhibits	gene	0.60
AMPK	activates	gene	0.60
STROKE	activates	gene	0.60
NEAT1	activates	gene	0.60
IL-1	associated_with	gene	0.60
TNC	inhibits	gene	0.60
IL-1	inhibits	gene	0.60
P2RX7	regulates	gene	0.60
NAD	activates	gene	0.60
IL-17	activates	gene	0.60
EGF	regulates	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
DEMENTIA	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
PARKINSON	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IL-4

Understanding Entity Pages

Wiki Pages (20)

Microglial Cells — Cell Type Hierarchy

NF-kB Signaling Pathway in Neurodegeneration

cGMP Signaling Pathway in Neurodegeneration

Microglia Activation Mechanism

CD200R1 Gene

NF-κB Signaling in Neurodegeneration

Neuroinflammation Pathway

IL3 (Interleukin 3)

Experiment: Autoimmune Hypothesis Testing in AD

Neuroinflammation and Microglia Pathway

Section 132: Advanced Systems Immunology and Network Pharmacology in CBS/PSP

CCR8 Gene

Nanomedicine for Alzheimer's Disease

CBS Microglial Neuroimmune Axis

Neuroimmune Dysfunction in Frontotemporal Dementia

GV1001 for Moderate to Severe Alzheimer's Disease (NCT05303701)

IL13 — Interleukin 13

IL25 (Interleukin 25)