concept

IL8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

194Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

Summary

IL8 is a concept in neurodegeneration research. Key relationships include: expressed in, activates, therapeutic target. Associated with Als, Breast Cancer, Cancer. Connected to 102 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	IL8
Key Genes/Proteins	TNF, NFKB, NFKB1, TPM2
Related Diseases	hyperoxia, Chronic Obstructive Pulmonary Disease, Tumor, INFLAMMATION, muscle wasting

Wiki Pages (9)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    IL8["IL8"]
    IL8 -->|"activates"| INFLAMMATION["INFLAMMATION"]
    IL8 -->|"expressed in"| Als["Als"]
    IL8 -->|"activates"| Epilepsy["Epilepsy"]
    IL8 -->|"activates"| Ms["Ms"]
    IL8 -->|"expressed in"| Innate_Immunity["Innate Immunity"]
    IL8 -->|"expressed in"| Toll_Like_Receptor["Toll-Like Receptor"]
    IL8 -->|"expressed in"| Immune_Response["Immune Response"]
    IL8 -->|"expressed in"| DICER1["DICER1"]
    IL8 -->|"expressed in"| NR3C1["NR3C1"]
    IL8 -->|"expressed in"| IL1B["IL1B"]
    hyperoxia["hyperoxia"] -->|"contributes to"| IL8
    TNF["TNF"] -->|"activates"| IL8
    NFKB1["NFKB1"] -->|"activates"| IL8
    TPM2["TPM2"] -->|"regulates"| IL8
    NFKB["NFKB"] -->|"regulates"| IL8
    DUPILUMAB["DUPILUMAB"] -->|"inhibits"| IL8
    GAL["GAL"] -->|"activates"| IL8
    CYTOKINES["CYTOKINES"] -->|"expressed in"| IL8
    TLR2["TLR2"] -->|"expressed in"| IL8
    OCLN["OCLN"] -->|"expressed in"| IL8

Outgoing (103)

Target	Relation	Type	Str
Chronic Obstructive Pulmonary Disease	associated_with	disease	0.85
Immune Aging	modulates	process	0.85
Tumor	therapeutic_target	disease	0.75
INFLAMMATION	activates	phenotype	0.72
muscle wasting	associated_with	phenotype	0.70
Als	expressed_in	disease	0.65
Epilepsy	activates	disease	0.65
Ms	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Cancer	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Inflammation	activates	disease	0.65
Rheumatoid Arthritis	therapeutic_target	disease	0.65
Breast Cancer	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Fibrosis	inhibits	disease	0.65
Als	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Obesity	inhibits	disease	0.65
Alzheimer	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Alzheimer	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Innate Immunity	expressed_in	pathway	0.60
Toll-Like Receptor	expressed_in	pathway	0.60
Immune Response	expressed_in	pathway	0.60
DICER1	expressed_in	gene	0.60
NR3C1	expressed_in	gene	0.60
IL1B	expressed_in	gene	0.60
AKT1	expressed_in	gene	0.60
COMT	expressed_in	gene	0.60
IL-6	expressed_in	gene	0.60
BDNF	expressed_in	gene	0.60
DISC1	expressed_in	gene	0.60
GCH1	expressed_in	gene	0.60
NDEL1	expressed_in	gene	0.60
FKBP5	expressed_in	gene	0.60
Epigenetic	expressed_in	pathway	0.60
Akt	expressed_in	pathway	0.60
Nf-Κb	expressed_in	pathway	0.60
TNF-Α	activates	gene	0.60
ANG	associated_with	gene	0.60
CXCL8	associated_with	gene	0.60
CXCL1	associated_with	gene	0.60
ROS	activates	gene	0.60
TNF	activates	gene	0.60
CCL2	associated_with	gene	0.60
DNA	activates	gene	0.60
CCL5	associated_with	gene	0.60

Incoming (91)

Source	Relation	Type	Str
hyperoxia	contributes_to	phenotype	0.90
TNF	activates	protein	0.90
NFKB	upregulates	protein	0.90
NFKB1	activates	gene	0.80
TPM2	regulates	gene	0.80
NFKB	regulates	protein	0.72
DUPILUMAB	inhibits	drug	0.72
GAL	activates	gene	0.60
CYTOKINES	expressed_in	gene	0.60
TLR2	expressed_in	gene	0.60
OCLN	expressed_in	gene	0.60
ZO1	expressed_in	gene	0.60
CLDN5	expressed_in	gene	0.60
CXCL8	regulates	gene	0.60
IL6	regulates	gene	0.60
RAB7A	regulates	gene	0.60
IL1B	regulates	gene	0.60
CD8	regulates	gene	0.60
EGFR	regulates	gene	0.60
HSP90AA1	regulates	gene	0.60
ACTB	regulates	gene	0.60
IFIH1	regulates	gene	0.60
ISG15	regulates	gene	0.60
MMP2	regulates	gene	0.60
SLC6A4	expressed_in	gene	0.60
TLR4	expressed_in	gene	0.60
IL1B	expressed_in	gene	0.60
TLR3	expressed_in	gene	0.60
PROINFLAMMATORY CYTOKINES	expressed_in	gene	0.60
NF-ΚB	expressed_in	gene	0.60
RAGE	expressed_in	gene	0.60
IRAK2	activates	gene	0.60
IL10	expressed_in	gene	0.60
IRAK1	expressed_in	gene	0.60
IKBKG	expressed_in	gene	0.60
TLR1	expressed_in	gene	0.60
HMGB1	expressed_in	gene	0.60
IKBKB	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
PI3K	activates	gene	0.60
NF-KB	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
GATA2	activates	gene	0.60
IL6	associated_with	gene	0.60
IL6	therapeutic_target	gene	0.60
BAX	therapeutic_target	gene	0.60
STAT1	therapeutic_target	gene	0.60
FAS	therapeutic_target	gene	0.60
INFLAMMATION	inhibits	gene	0.60
S100A9	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IL8

Understanding Entity Pages

Summary

Wiki Pages (9)

Cellular Senescence Hypothesis in Parkinson's Disease

Cellular Senescence Disease Comparison

CBS Single-Cell Transcriptomics Mechanisms

TPM2 — Tropomyosin 2

TNF - Tumor Necrosis Factor

TNF Alpha Protein

Senescent Neurons

NF-κB p105 Protein