protein

LC3B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LC3B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1779Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

LC3B is a protein involved in neurodegeneration research. Key relationships include: activates, interacts with, associated with. Associated with AD, ALI, ALS. Connected to 888 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	LC3B
Pathways	Amyloid Beta Clearance
GeneCards	LC3B
Human Protein Atlas	LC3B
Associated Diseases	AD, ALI, ALS, Aging, Alzheimer
Known Drugs/Compounds	curcumin, rapamycin
Interactions	DRP1, SESN2, RB1, ATG, BCL2L13, SNCAIP
KG Connections	1779 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    LC3B["LC3B"] -->|"regulates"| autophagy["autophagy"]
    LC3B["LC3B"] -->|"associated"| AUTOPHAGY["AUTOPHAGY"]
    LC3B["LC3B"] -->|"associated"| LIPOPHAGY["LIPOPHAGY"]
    LC3B["LC3B"] -->|"prevents"| Alzheimer_s_disease["Alzheimer's disease"]
    LC3B["LC3B"] -->|"biomarker for"| autophagy_1["autophagy"]
    LC3B["LC3B"] -->|"regulates"| amyloid_beta["amyloid beta"]
    CALCOCO2["CALCOCO2"] -->|"interacts"| LC3B["LC3B"]
    BEX2["BEX2"] -->|"regulates"| LC3B["LC3B"]
    NDP52["NDP52"] -->|"interacts"| LC3B["LC3B"]
    BNIP3["BNIP3"] -->|"interacts"| LC3B["LC3B"]
    style LC3B fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1014)

Target	Relation	Type	Str
Autophagy	associated_with	pathway	1.00
Autophagy	activates	pathway	1.00
Als	activates	disease	1.00
Cancer	activates	disease	1.00
AUTOPHAGY	associated_with	gene	1.00
AUTOPHAGY	activates	gene	1.00
P62	activates	gene	1.00
Mtor	activates	pathway	1.00
Tumor	activates	disease	0.95
Inflammation	activates	disease	0.95
Infection	activates	disease	0.95
autophagy	regulates	phenotype	0.90
autophagy pathway	participates_in	pathway	0.90
Autophagosome Formation	biomarker_for	process	0.90
neural stem cells	activates	cell_type	0.90
Autophagy	interacts_with	pathway	0.90
Mitophagy	activates	pathway	0.90
Autophagy	inhibits	pathway	0.90
Apoptosis	activates	pathway	0.90
P62	associated_with	gene	0.90
MTOR	activates	gene	0.90
Amyloid Beta Clearance	involved_in	process	0.88
Mitophagy	involved_in	process	0.87
Als	interacts_with	disease	0.85
Als	regulates	disease	0.85
Breast Cancer	activates	disease	0.85
LIPOPHAGY	associated_with	gene	0.80
Parkinson's disease	regulates	disease	0.80
oxidative stress response	participates_in	pathway	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
apoptosis pathway	participates_in	pathway	0.80
neural stem cells	regulates	cell_type	0.80
MAP1LC3B	activates	gene	0.80
PARKIN	activates	gene	0.80
Autophagy	expressed_in	pathway	0.80
P62	inhibits	gene	0.80
NBR1	activates	gene	0.80
SQSTM1	activates	gene	0.80
AUTOPHAGY	expressed_in	gene	0.80
UBIQUITIN	interacts_with	gene	0.80
MAP1LC3B	interacts_with	gene	0.80
CGAS-STING	activates	gene	0.80
Cancer	associated_with	disease	0.75
Aging	inhibits	disease	0.75
Inflammation	inhibits	disease	0.75
Tumor	expressed_in	disease	0.75
Cancer	inhibits	disease	0.75
Parkinson	activates	disease	0.75
Als	associated_with	disease	0.75
Aging	implicated_in	disease	0.75

Incoming (765)

Source	Relation	Type	Str
LC3	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
CANCER	activates	gene	1.00
CALCOCO2	interacts_with	protein	0.90
Amyloid Beta	upregulates	protein	0.90
Thermal Adaptation	upregulates	process	0.90
AUTOPHAGY	inhibits	gene	0.90
CGAS	activates	gene	0.90
P62	activates	gene	0.90
APOPTOSIS	activates	gene	0.90
ATG2A	interacts_with	gene	0.88
Thermal adaptation	upregulates	process	0.85
BEX2	regulates	protein	0.80
NDP52	interacts_with	protein	0.80
BNIP3	interacts_with	protein	0.80
FURIN	regulates	gene	0.80
Nobiletin	upregulates	compound	0.80
OPTN	interacts_with	gene	0.80
STING	activates	gene	0.80
AUTOPHAGY	interacts_with	gene	0.80
LC3	interacts_with	gene	0.80
MITOPHAGY	activates	gene	0.80
AUTOPHAGY	associated_with	gene	0.80
ROS	activates	gene	0.80
MTORC1	activates	gene	0.80
INFLAMMATION	activates	gene	0.80
MAP1LC3B	encodes	gene	0.70
amyloid beta	activates	protein	0.70
DNM1L	interacts_with	gene	0.70
SQSTM1	associated_with	gene	0.70
PTEN	activates	gene	0.70
SQSTM1	activates	gene	0.70
MTDNA	activates	gene	0.70
ATG7	associated_with	gene	0.70
AMPK	activates	gene	0.70
PARKINSON'S DISEASE	activates	gene	0.70
MITOPHAGY	interacts_with	gene	0.70
CANCER	associated_with	gene	0.70
AUTOPHAGY	regulates	gene	0.70
APOPTOSIS	associated_with	gene	0.70
INFLAMMATION	inhibits	gene	0.70
FUNDC1	interacts_with	gene	0.70
PINK1	activates	gene	0.70
CYTOKINES	activates	gene	0.70
PROINFLAMMATORY CYTOKINES	activates	gene	0.70
ROS	associated_with	gene	0.70
FERROPTOSIS	associated_with	gene	0.70
TFEB	activates	gene	0.70
LYSOSOME	activates	gene	0.70
ATG7	activates	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

LC3B

Understanding Entity Pages

Summary

Wiki Pages (20)

Autophagy Mechanisms

Arcuate Nucleus POMC Neurons

proteostasis-triad-pulses

RETREG3 (Reticulophagy Regulator 3)

PARK2 - Parkin

Lipid Droplet-Lysosome Axis Therapeutic Testing in Parkinson's Disease

Autophagy Enhancement Drug Screening for Neurodegeneration

PARK2 Protein

txnip

ATG4D Gene

ATG4B — Autophagy Related 4B Cysteine Peptidase

tubb3-protein

LRP2 — Low Density Lipoprotein Receptor-Related Protein 2 (Megalin)

ATG4C Gene

ATG3 Gene

TOMM20 — Translocase of Outer Mitochondrial Membrane 20

SOX9 Gene

TOMM20 Protein