concept

IMMUNE INFILTRATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IMMUNE INFILTRATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

624Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

IMMUNE INFILTRATION is a concept in neurodegeneration research. Key relationships include: associated with, therapeutic target, expressed in. Associated with Aging, Als, Alzheimer. Connected to 417 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	IMMUNE INFILTRATION
Key Genes/Proteins	ACO2, AGING, AIM2, AKT, AKT1, ALZHEIMER
Related Diseases	aging, Aging, Als, ALS, Alzheimer
Related Pathways	Adaptive Immunity, Akt

Pathway Diagram

graph TD
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    IMMUNE_INFILTRATION -->|"causes"| INFLAMMATION["INFLAMMATION"]
    IMMUNE_INFILTRATION -->|"activates"| Neuropathy["Neuropathy"]
    IMMUNE_INFILTRATION -->|"activates"| Ms["Ms"]
    IMMUNE_INFILTRATION -->|"target for"| Carcinoma["Carcinoma"]
    IMMUNE_INFILTRATION -->|"target for"| Cancer["Cancer"]
    IMMUNE_INFILTRATION -->|"activates"| Tumor["Tumor"]
    MICROGLIA["MICROGLIA"] -->|"activates"| IMMUNE_INFILTRATION
    ASTROCYTES["ASTROCYTES"] -->|"activates"| IMMUNE_INFILTRATION
    BECN1["BECN1"] -->|"activates"| IMMUNE_INFILTRATION
    PYROPTOSIS["PYROPTOSIS"] -->|"activates"| IMMUNE_INFILTRATION
    GSDME["GSDME"] -->|"activates"| IMMUNE_INFILTRATION
    CD8["CD8"] -->|"activates"| IMMUNE_INFILTRATION
    MMP9["MMP9"] -->|"regulates"| IMMUNE_INFILTRATION
    GADD45A["GADD45A"] -->|"regulates"| IMMUNE_INFILTRATION

Outgoing (350)

Target	Relation	Type	Str
Septic Cardiomyopathy	contributes_to	disease	0.95
INFLAMMATION	causes	gene	0.90
Inflammation	associated_with	disease	0.85
Cancer	associated_with	disease	0.85
Als	associated_with	disease	0.85
Autophagy	associated_with	pathway	0.80
Cancer	therapeutic_target	disease	0.75
Als	therapeutic_target	disease	0.75
Tumor	associated_with	disease	0.75
Tumor	activates	disease	0.75
Alzheimer	associated_with	disease	0.75
Parkinson	associated_with	disease	0.75
Mtor	associated_with	pathway	0.70
CANCER	associated_with	gene	0.70
Mapk	biomarker_for	pathway	0.70
Immune Response	therapeutic_target	pathway	0.70
Ms	regulates	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Leukemia	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Neurodegeneration	regulates	disease	0.65
ALS	associated_with	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Stroke	biomarker_for	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
Migraine	regulates	disease	0.65
Cancer	activates	disease	0.65
Autoimmune	therapeutic_target	disease	0.65
Senescence	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
ALS	expressed_in	disease	0.65
Hepatitis	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Neuroinflammation	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
Cancer	expressed_in	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Carcinoma	associated_with	disease	0.65
Tumor	regulates	disease	0.65
Aging	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Aging	activates	disease	0.65
ALS	activates	disease	0.65
Fibrosis	activates	disease	0.65
Sepsis	biomarker_for	disease	0.65
Rheumatoid Arthritis	therapeutic_target	disease	0.65
Aging	biomarker_for	disease	0.65

Incoming (274)

Source	Relation	Type	Str
GENES	associated_with	gene	0.80
INFLAMMATION	associated_with	gene	0.80
MMP9	associated_with	gene	0.70
ASTROCYTES	activates	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
ALZHEIMER'S DISEASE	associated_with	gene	0.70
LAMP1	associated_with	gene	0.70
MIRNAS	associated_with	gene	0.60
FOS	interacts_with	gene	0.60
OPA1	associated_with	gene	0.60
CD8	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60
CASP1	expressed_in	gene	0.60
MAPK8	expressed_in	gene	0.60
CD8	expressed_in	gene	0.60
AGING	therapeutic_target	gene	0.60
DOCK2	therapeutic_target	gene	0.60
CDK1	therapeutic_target	gene	0.60
PTGS2	therapeutic_target	gene	0.60
IL7R	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
TMEM173	associated_with	gene	0.60
STING1	associated_with	gene	0.60
CD4	biomarker_for	gene	0.60
ZAP70	biomarker_for	gene	0.60
MFN1	biomarker_for	gene	0.60
DIABETES MELLITUS	biomarker_for	gene	0.60
IL1B	associated_with	gene	0.60
SOD2	associated_with	gene	0.60
MARCKS	associated_with	gene	0.60
MBP	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
TIMP1	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
GATA2	therapeutic_target	gene	0.60
PDGFRB	therapeutic_target	gene	0.60
EP300	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
TXN	biomarker_for	gene	0.60
OXIDATIVE STRESS	biomarker_for	gene	0.60
MAPK14	biomarker_for	gene	0.60
BCL2	biomarker_for	gene	0.60
GENES	biomarker_for	gene	0.60
APOPTOSIS	activates	gene	0.60
CANCER	activates	gene	0.60
GENES	activates	gene	0.60
STING	activates	gene	0.60
GBM	therapeutic_target	gene	0.60
GLIOBLASTOMA	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IMMUNE INFILTRATION in their description or question text

No additional research found