concept

IMMUNE INFILTRATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IMMUNE INFILTRATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

624Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

IMMUNE INFILTRATION is a concept in neurodegeneration research. Key relationships include: associated with, therapeutic target, expressed in. Associated with Aging, Als, Alzheimer. Connected to 417 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	IMMUNE INFILTRATION
Key Genes/Proteins	ACO2, AGING, AIM2, AKT, AKT1, ALZHEIMER
Related Diseases	aging, Aging, Als, ALS, Alzheimer
Related Pathways	Adaptive Immunity, Akt

Pathway Diagram

graph TD
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    IMMUNE_INFILTRATION -->|"causes"| INFLAMMATION["INFLAMMATION"]
    IMMUNE_INFILTRATION -->|"activates"| Neuropathy["Neuropathy"]
    IMMUNE_INFILTRATION -->|"activates"| Ms["Ms"]
    IMMUNE_INFILTRATION -->|"target for"| Carcinoma["Carcinoma"]
    IMMUNE_INFILTRATION -->|"target for"| Cancer["Cancer"]
    IMMUNE_INFILTRATION -->|"activates"| Tumor["Tumor"]
    MICROGLIA["MICROGLIA"] -->|"activates"| IMMUNE_INFILTRATION
    ASTROCYTES["ASTROCYTES"] -->|"activates"| IMMUNE_INFILTRATION
    BECN1["BECN1"] -->|"activates"| IMMUNE_INFILTRATION
    PYROPTOSIS["PYROPTOSIS"] -->|"activates"| IMMUNE_INFILTRATION
    GSDME["GSDME"] -->|"activates"| IMMUNE_INFILTRATION
    CD8["CD8"] -->|"activates"| IMMUNE_INFILTRATION
    MMP9["MMP9"] -->|"regulates"| IMMUNE_INFILTRATION
    GADD45A["GADD45A"] -->|"regulates"| IMMUNE_INFILTRATION

Outgoing (350)

Target	Relation	Type	Str
Septic Cardiomyopathy	contributes_to	disease	0.95
INFLAMMATION	causes	gene	0.90
Cancer	associated_with	disease	0.85
Inflammation	associated_with	disease	0.85
Als	associated_with	disease	0.85
Autophagy	associated_with	pathway	0.80
Tumor	associated_with	disease	0.75
Als	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
Parkinson	associated_with	disease	0.75
Alzheimer	associated_with	disease	0.75
Tumor	activates	disease	0.75
Mtor	associated_with	pathway	0.70
Immune Response	therapeutic_target	pathway	0.70
Mapk	biomarker_for	pathway	0.70
CANCER	associated_with	gene	0.70
Atherosclerosis	associated_with	disease	0.65
Fibrosis	biomarker_for	disease	0.65
Hepatitis	associated_with	disease	0.65
Migraine	regulates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Diabetes	biomarker_for	disease	0.65
Ms	activates	disease	0.65
Senescence	therapeutic_target	disease	0.65
Neurodegeneration	regulates	disease	0.65
Aging	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Diabetes	associated_with	disease	0.65
Als	biomarker_for	disease	0.65
Melanoma	activates	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Stroke	biomarker_for	disease	0.65
Lung Cancer	activates	disease	0.65
Neuropathy	activates	disease	0.65
Carcinoma	associated_with	disease	0.65
Fibrosis	associated_with	disease	0.65
Cancer	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Tumor	regulates	disease	0.65
Autoimmune	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Cirrhosis	associated_with	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Heart Failure	expressed_in	disease	0.65
Rheumatoid Arthritis	therapeutic_target	disease	0.65
Atherosclerosis	biomarker_for	disease	0.65
Cancer	activates	disease	0.65
Leukemia	activates	disease	0.65

Incoming (274)

Source	Relation	Type	Str
GENES	associated_with	gene	0.80
INFLAMMATION	associated_with	gene	0.80
ALZHEIMER'S DISEASE	associated_with	gene	0.70
MMP9	associated_with	gene	0.70
LAMP1	associated_with	gene	0.70
ASTROCYTES	activates	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
VPS13C	associated_with	gene	0.60
MITOPHAGY	associated_with	gene	0.60
BNIP3L	associated_with	gene	0.60
PYROPTOSIS	activates	gene	0.60
GSDME	activates	gene	0.60
CD8	activates	gene	0.60
MMP9	regulates	gene	0.60
GADD45A	regulates	gene	0.60
MAPK14	regulates	gene	0.60
MIRNAS	interacts_with	gene	0.60
PI3K	regulates	gene	0.60
AKT	regulates	gene	0.60
TFRC	regulates	gene	0.60
FERROPTOSIS	regulates	gene	0.60
PLIN1	expressed_in	gene	0.60
CD4	associated_with	gene	0.60
THBS2	expressed_in	gene	0.60
CTSK	expressed_in	gene	0.60
MARCKS	expressed_in	gene	0.60
MYC	associated_with	gene	0.60
CYTOKINES	associated_with	gene	0.60
MCC	associated_with	gene	0.60
ICAM1	associated_with	gene	0.60
SPHK1	associated_with	gene	0.60
BNIP3	associated_with	gene	0.60
MFN1	associated_with	gene	0.60
NDUFAF7	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
NDUFAF1	associated_with	gene	0.60
CD44	biomarker_for	gene	0.60
IGF1	biomarker_for	gene	0.60
EGF	biomarker_for	gene	0.60
TMEM173	associated_with	gene	0.60
STING1	associated_with	gene	0.60
PIK3CA	associated_with	gene	0.60
CDK6	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
TGFBR1	associated_with	gene	0.60
TIMP1	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
GATA2	therapeutic_target	gene	0.60
PDGFRB	therapeutic_target	gene	0.60
EP300	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IMMUNE INFILTRATION in their description or question text

No additional research found