concept

P21

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P21: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

677Connections

4Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

9Debates

Summary

P21 is a concept in neurodegeneration research. Key relationships include: activates, regulates, expressed in. Associated with ALS, Aging, Als. Connected to 289 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	P21
Key Genes/Proteins	ACTB, Actin, ADNP, AGING, AIF, AKT
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Akt

Wiki Pages (1)

Knowledge base pages for this entity

NUP214 — Nucleoporin 214

gene · 1172 words

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Pathway Diagram

graph TD
    P21["P21"]
    P21 -->|"activates"| senescence["senescence"]
    P21 -->|"regulates"| cellular_senescence["cellular senescence"]
    P21 -->|"activates"| Aging["Aging"]
    P21 -->|"regulates"| ALS["ALS"]
    P21 -->|"inhibits"| Senescence["Senescence"]
    P21 -->|"regulates"| Inflammation["Inflammation"]
    P21 -->|"inhibits"| Tumor["Tumor"]
    P21 -->|"inhibits"| Cancer["Cancer"]
    P21 -->|"activates"| Ms["Ms"]
    P21 -->|"activates"| Als["Als"]
    P21 -->|"activates"| Depression["Depression"]
    PRDM4["PRDM4"] -->|"upregulates"| P21
    PRKCH["PRKCH"] -->|"regulates"| P21
    APOPTOSIS["APOPTOSIS"] -->|"activates"| P21
    AND["AND"] -->|"activates"| P21
    TERC["TERC"] -->|"regulates"| P21
    GENES["GENES"] -->|"regulates"| P21
    CYTOKINES["CYTOKINES"] -->|"regulates"| P21
    DNA["DNA"] -->|"inhibits"| P21
    AMPK["AMPK"] -->|"activates"| P21
    ATP["ATP"] -->|"activates"| P21
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| P21

Outgoing (376)

Target	Relation	Type	Str
Als	activates	disease	1.00
Aging	activates	disease	1.00
Oxidative Stress	activates	pathway	0.90
Senescence	activates	disease	0.85
Senescence	regulates	disease	0.85
Cancer	activates	disease	0.85
Tumor	activates	disease	0.85
senescent cells	expressed_in	cell_type	0.80
senescence	activates	pathway	0.80
BCL-2	upstream_of	protein	0.80
Apoptosis	activates	pathway	0.80
Cell Cycle	activates	pathway	0.80
Als	therapeutic_target	disease	0.75
Lung Cancer	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
Tumor	inhibits	disease	0.75
Inflammation	regulates	disease	0.75
Cancer	expressed_in	disease	0.75
cellular senescence	regulates	process	0.70
cellular senescence	activates	mechanism	0.70
neuroinflammation	causes	mechanism	0.70
MTOR	regulates	gene	0.70
Mtor	regulates	pathway	0.70
Cell Cycle	inhibits	pathway	0.70
Cancer	regulates	disease	0.65
Glioblastoma	expressed_in	disease	0.65
Atherosclerosis	regulates	disease	0.65
Depression	activates	disease	0.65
Carcinoma	activates	disease	0.65
Ms	activates	disease	0.65
Fibrosis	activates	disease	0.65
ALS	activates	disease	0.65
Cancer	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Tumor	therapeutic_target	disease	0.65
Obesity	activates	disease	0.65
Tumor	expressed_in	disease	0.65
Viral Infection	activates	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Longevity	activates	disease	0.65
Tumor	regulates	disease	0.65
Parkinson	inhibits	disease	0.65
Aging	treats	disease	0.65
Senescence	expressed_in	disease	0.65
Als	regulates	disease	0.65
Als	treats	disease	0.65
Pancreatic Cancer	expressed_in	disease	0.65
Sarcopenia	treats	disease	0.65
Ataxia	activates	disease	0.65
Alzheimer	inhibits	disease	0.65

Incoming (301)

Source	Relation	Type	Str
P53	regulates	gene	1.00
OXIDATIVE STRESS	activates	gene	0.90
AGING	activates	gene	0.90
Polygonatum sibiricum polysaccharide	downregulates	compound	0.85
PRDM4	upregulates	gene	0.80
Polygonatum Sibiricum Polysaccharide	downregulates	compound	0.80
DNA	activates	gene	0.80
P53	inhibits	gene	0.80
P53	activates	gene	0.80
APOPTOSIS	activates	gene	0.80
GENES	expressed_in	gene	0.80
CANCER	activates	gene	0.80
CANCER	expressed_in	gene	0.70
GENES	regulates	gene	0.70
SQSTM1	regulates	gene	0.70
AMPK	activates	gene	0.70
P16	regulates	gene	0.70
P62	regulates	gene	0.70
GAL	activates	gene	0.70
CANCER	therapeutic_target	gene	0.70
GENES	inhibits	gene	0.70
BAX	expressed_in	gene	0.70
BCL-2	expressed_in	gene	0.70
CDKN1A	inhibits	gene	0.70
PRKCH	regulates	gene	0.70
ROS	activates	gene	0.60
BAX	biomarker_for	gene	0.60
APOPTOSIS	biomarker_for	gene	0.60
BECN1	biomarker_for	gene	0.60
TNF	biomarker_for	gene	0.60
ATG5	biomarker_for	gene	0.60
TP53	activates	gene	0.60
CDKN1A	activates	gene	0.60
STAT3	inhibits	gene	0.60
IL6	inhibits	gene	0.60
P53	biomarker_for	gene	0.60
IL-6	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
P16	biomarker_for	gene	0.60
CYCLIN D1	expressed_in	gene	0.60
P53	expressed_in	gene	0.60
SMAD4	expressed_in	gene	0.60
RAS	expressed_in	gene	0.60
P16	expressed_in	gene	0.60
EGF	expressed_in	gene	0.60
CDK4	activates	gene	0.60
ATM	activates	gene	0.60
DR5	activates	gene	0.60
TRAIL	activates	gene	0.60
AMYLOID	phosphorylates	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
p21^Cip1 Phospho-State as Autophagy Responsiveness Predictor	0.768	molecular-biology	What is the optimal therapeutic window t
Timed Senolytic Therapy Eliminates p16^Ink4a/p21^Cip1-Senesc	0.564	neuroinflammation	What molecular mechanisms drive the tran
Nucleolar p21-rRNA Co-Aggregation as Irreversible Senescence	0.500	molecular-biology	What is the optimal therapeutic window t
p21-Targeted Proteolysis-Targeting Chimeras (PROTACs)	0.000	-	Senolytic therapy for age-related neurod

Mentioning Analyses (2)

Scientific analyses that reference this entity

Can P16INK4A expression reliably distinguish harmful from beneficial senescent m

neurodegeneration | 2026-04-11 | 0 hypotheses

Senescent cell clearance as neurodegeneration therapy

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.769

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (9)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning P21 in their description or question text

No additional research found

P21

Understanding Entity Pages

Summary

Wiki Pages (1)

NUP214 — Nucleoporin 214

Pathway Diagram

Outgoing (376)

Incoming (301)

Targeting Hypotheses (4)

Mentioning Analyses (2)

Can P16INK4A expression reliably distinguish harmful from beneficial senescent m

Senescent cell clearance as neurodegeneration therapy

Experiments (0)

Related Papers (0)

Debates (9)

Extended debate: Metabolic Reprogramming to Reverse Senescence

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

Hypothesis debate: SASP Modulation Rather Than Cell Elimination

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

Should metabolic reprogramming via SIRT1/NAD+/PGC-1alpha axis be prioritized to

The debate proposed P16INK4A-guided targeting but the Skeptic noted microglia ex

Investigate the therapeutic potential of clearing senescent cells (senolytics) t

Senescent cell clearance as neurodegeneration therapy

Related Research