P21

Understanding Entity Pages

This page aggregates everything SciDEX knows about P21: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

P21 is a concept in neurodegeneration research. Key relationships include: activates, regulates, expressed in. Associated with ALS, Aging, Als. Connected to 289 entities in the SciDEX knowledge graph.

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graph TD
    P21["<b>P21</b>"]
    P21 -->|"activates"| senescence["senescence"]
    P21 -->|"regulates"| cellular_senescence["cellular senescence"]
    P21 -->|"activates"| Aging["Aging"]
    P21 -->|"regulates"| ALS["ALS"]
    P21 -->|"inhibits"| Senescence["Senescence"]
    P21 -->|"regulates"| Inflammation["Inflammation"]
    P21 -->|"inhibits"| Tumor["Tumor"]
    P21 -->|"inhibits"| Cancer["Cancer"]
    P21 -->|"activates"| Ms["Ms"]
    P21 -->|"activates"| Als["Als"]
    P21 -->|"activates"| Depression["Depression"]
    PRDM4["PRDM4"] -->|"upregulates"| P21
    PRKCH["PRKCH"] -->|"regulates"| P21
    APOPTOSIS["APOPTOSIS"] -->|"activates"| P21
    AND["AND"] -->|"activates"| P21
    TERC["TERC"] -->|"regulates"| P21
    GENES["GENES"] -->|"regulates"| P21
    CYTOKINES["CYTOKINES"] -->|"regulates"| P21
    DNA["DNA"] -->|"inhibits"| P21
    AMPK["AMPK"] -->|"activates"| P21
    ATP["ATP"] -->|"activates"| P21
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| P21