protein

CHIP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHIP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

151Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Page for CHIP Protein (STUB1)

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🔬 Protein Info

Gene Symbol	CHIP
Aliases	STUB1
Function	Chip Protein (Stub1) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Molecular Weight	34.5 kDa
Pathways	Dna Repair, Dna Damage Response
GeneCards	CHIP
Human Protein Atlas	CHIP
Associated Diseases	ALS, Alzheimer, CKD, COPD, Cardiovascular Disease, Chronic Kidney Disease
Interactions	APP, EPHA2, FLOT1, MAPK, P38, ALZHEIMER
KG Connections	151 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CHIP["<b>CHIP</b>"]
    Cardiovascular_Disease{"Cardiovascular Disease"}
    CHIP -->|"risk factor for"| Cardiovascular_Disease
    Leukemia{"Leukemia"}
    CHIP -->|"risk factor for"| Leukemia
    Inflammation(["Inflammation"])
    CHIP -->|"causes"| Inflammation
    COPD{"COPD"}
    CHIP -->|"associated with"| COPD
    Chronic_Kidney_Disease{"Chronic Kidney Disease"}
    CHIP -->|"associated with"| Chronic_Kidney_Disease
    Stroke{"Stroke"}
    CHIP -->|"associated with"| Stroke
    Pulmonary_Embolism{"Pulmonary Embolism"}
    CHIP -->|"associated with"| Pulmonary_Embolism
    Alzheimer_s_Disease{"Alzheimer's Disease"}
    CHIP -->|"protects against"| Alzheimer_s_Disease
    Epigenetic_Regulators["Epigenetic Regulators"]
    Epigenetic_Regulators -->|"involved in"| CHIP
    style CHIP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (95)

Target	Relation	Type	Str
Cardiovascular Disease	risk_factor_for	disease	0.95
Leukemia	risk_factor_for	disease	0.90
CARDIOVASCULAR DISEASE	associated_with	entity	0.90
Acute Myeloid Leukemia	risk_factor_for	disease	0.90
Inflammation	causes	process	0.85
inflammation	promotes	process	0.85
Coronary Artery Disease	risk_factor_for	disease	0.85
Myocardial Infarction	risk_factor_for	disease	0.85
Cardiovascular Disease	associated_with	disease	0.80
Malignancy	associated_with	disease	0.80
ALZHEIMER'S DISEASE	protects_against	entity	0.80
NEUROINFLAMMATION	modulates	entity	0.80
cardiovascular disease	implicated_in	disease	0.80
COPD	associated_with	disease	0.75
Chronic Kidney Disease	associated_with	disease	0.75
Stroke	associated_with	disease	0.75
Pulmonary Embolism	associated_with	disease	0.75
Pulmonary Embolism	risk_factor_for	disease	0.75
Stroke	risk_factor_for	disease	0.75
Alzheimer's Disease	protects_against	disease	0.70
CKD	associated_with	disease	0.70
Chronic Obstructive Pulmonary Disease	associated_with	disease	0.70
mitophagy	inhibits	process	0.70
SCA48	causes	disease	0.70
SCAR16	causes	disease	0.70
ALS	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
dementia	associated_with	disease	0.60
frontotemporal	associated_with	disease	0.60
neurodegeneration	associated_with	disease	0.60
APP	interacts_with	gene	0.50
EPHA2	activates	gene	0.50
FLOT1	activates	gene	0.50
MAPK	activates	gene	0.50
NEURON	co_discussed	gene	0.50
P38	activates	protein	0.50
WAS	co_discussed	protein	0.50
Cardiovascular	interacts_with	disease	0.50
disease	interacts_with	disease	0.50
CARDIOVASCULAR DISEASE	interacts_with	concept	0.50
OBESITY	activates	disease	0.50
disease	activates	disease	0.50
COPD	activates	disease	0.50
ALZHEIMER	interacts_with	gene	0.50
Alzheimer'S Disease	interacts_with	disease	0.50
ALZHEIMER'S	interacts_with	concept	0.50
Dna Repair	regulates	pathway	0.50
Leukemia	activates	disease	0.50
Heart Failure	activates	disease	0.50
Macrophage	inhibits	cell_type	0.50

Incoming (56)

Source	Relation	Type	Str
EPIGENETIC REGULATORS	involved_in	entity	0.85
DNA REPAIR GENES	involved_in	entity	0.85
Epigenetic Regulators	involved_in	protein	0.80
ALZHEIMER	activates	gene	0.50
AMYLOID	activates	gene	0.50
TAU	activates	protein	0.50
ALZHEIMER	protects_against	gene	0.50
DOT1L	regulates	gene	0.50
STROKE	activates	gene	0.50
SIRT6	inhibits	gene	0.50
TFEB	activates	protein	0.50
ACTB	activates	gene	0.50
Autophagy	activates	process	0.50
ULK1	activates	gene	0.50
SETX	activates	gene	0.50
BECN1	activates	gene	0.50
GABA	activates	gene	0.50
SQSTM1	activates	gene	0.50
SMN1	activates	gene	0.50
WIPI2	activates	gene	0.50
ALS4	activates	gene	0.50
ATG7	activates	protein	0.50
GABARAP	activates	protein	0.50
NDP52	activates	gene	0.50
CALCOCO2	activates	gene	0.50
IRF1	activates	gene	0.50
NPM1	activates	gene	0.50
NLRC5	activates	gene	0.50
CIITA	activates	protein	0.50
CHD4	activates	protein	0.50
mTOR	interacts_with	entity	0.50
IGF2BP2	inhibits	gene	0.50
OMA1	inhibits	gene	0.50
STAT3	activates	gene	0.50
TRPM7	activates	gene	0.50
NLRP3	activates	protein	0.50
EGFR	activates	gene	0.50
SENP1	activates	gene	0.50
EPHA2	interacts_with	gene	0.50
FLOT1	interacts_with	gene	0.50
MLCK	regulates	gene	0.50
IL-1Β	activates	protein	0.50
HDAC3	associated_with	gene	0.50
NPAS4	activates	gene	0.50
HDAC3	activates	gene	0.50
CD33	associated_with	gene	0.50
TREM2	associated_with	gene	0.50
microglia	associated_with	cell_type	0.50
INPP5D	associated_with	gene	0.50
SORL1	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CHIP

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

NPM1 Gene

CBS/PSP Treatment Rankings

GRIA3 Gene

NRF2 Oxidative Stress Pathway

Sulforaphane and Nrf2 Activation for Neuroprotection

Blood-Brain Barrier Biology and Crossing Strategies

blood-brain-barrier

nlrc5-protein

Epigenetic Alterations in Alzheimer's Disease

NPAS3 Gene

proteasome-ubiquitin-system-dysfunction-parkinsons

FOXO1 Protein

UBE2L3 — Ubiquitin-Conjugating Enzyme E2 L3

Transcriptional Regulation in Neurodegeneration

SNCA→Alpha-synuclein→Aggregation→Lewy Bodies→Synucleinopathies Causal Chain

Allen Human Brain Atlas

ubiquitin-proteasome-dysfunction-neurodegeneration