Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CANCER: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Cancer encompasses a group of diseases characterized by uncontrolled cell growth, invasion, and metastasis. In the context of neurodegenerative disease research, cancer pathways are relevant because many neuroprotective mechanisms overlap with tumor suppressor pathways. Key shared pathways include apoptosis, autophagy, DNA damage response, and cell cycle regulation. Understanding the inverse relationship between cancer and neurodegeneration informs therapeutic strategies.
| Gene Symbol | CANCER |
| Aliases | cancer |
| Associated Diseases | ALS, Aging, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety |
| Known Drugs/Compounds | RAPAMYCIN, PACLITAXEL, CISPLATIN, QUERCETIN, CURCUMIN, OXALIPLATIN |
| Interactions | MTOR, APOPTOSIS, NEURODEGENERATIVE DISORDERS, AUTOPHAGY, MTORC1, TSC2 |
| KG Connections | 8021 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
subgraph Therapeutic["Therapeutic"]
CANCER["CANCER"] -->|"therapeutic target"| Cancer["Cancer"]
CANCER["CANCER"] -->|"therapeutic target"| Mtor["Mtor"]
CANCER["CANCER"] -->|"therapeutic target"| MTOR["MTOR"]
CANCER["CANCER"] -->|"therapeutic target"| AKT["AKT"]
CANCER["CANCER"] -->|"therapeutic target"| Tumor["Tumor"]
end
subgraph Signaling["Signaling"]
CANCER["CANCER"] -->|"regulates"| Angiogenesis["Angiogenesis"]
CANCER["CANCER"] -->|"activates"| Wnt["Wnt"]
CANCER["CANCER"] -->|"activates"| Mapk["Mapk"]
CANCER["CANCER"] -->|"activates"| MTOR_1["MTOR"]
STAT3["STAT3"] -->|"activates"| CANCER["CANCER"]
INFLAMMATION["INFLAMMATION"] -->|"activates"| CANCER["CANCER"]
APOPTOSIS["APOPTOSIS"] -.->|"inhibits"| CANCER["CANCER"]
AUTOPHAGY_2["AUTOPHAGY"] -->|"regulates"| CANCER["CANCER"]
end
subgraph Pathology["Pathology"]
AUTOPHAGY["AUTOPHAGY"] -->|"associated with"| CANCER["CANCER"]
PI3K["PI3K"] -->|"associated with"| CANCER["CANCER"]
end
style CANCER fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style Cancer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Angiogenesis fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Mtor fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MTOR fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AKT fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Tumor fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Wnt fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Mapk fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MTOR_1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style STAT3 fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style INFLAMMATION fill:#5d4400,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AUTOPHAGY fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PI3K fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style APOPTOSIS fill:#5d4400,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AUTOPHAGY_2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | therapeutic_target | disease | 1.00 |
| Angiogenesis | regulates | pathway | 1.00 |
| Mtor | therapeutic_target | pathway | 1.00 |
| MTOR | therapeutic_target | gene | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Wnt | activates | pathway | 1.00 |
| Mapk | activates | pathway | 1.00 |
| MTOR | activates | gene | 1.00 |
| Als | activates | disease | 1.00 |
| Aging | activates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Mtor | activates | pathway | 1.00 |
| MTOR | regulates | gene | 1.00 |
| Als | regulates | disease | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Mtor | regulates | pathway | 1.00 |
| Als | interacts_with | disease | 1.00 |
| Cancer | regulates | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Epigenetic | activates | pathway | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| Cardiovascular | activates | disease | 1.00 |
| Autoimmune | activates | disease | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Carcinoma | activates | disease | 1.00 |
| Glioblastoma | activates | disease | 1.00 |
| Lipid Metabolism | activates | pathway | 1.00 |
| Tumor | contributes_to | disease | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Senescence | associated_with | disease | 1.00 |
| Nf-Κb | inhibits | pathway | 1.00 |
| Mtor | inhibits | pathway | 1.00 |
| AUTOPHAGY | inhibits | gene | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| Apoptosis | inhibits | pathway | 1.00 |
| Autophagy | inhibits | pathway | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| Apoptosis | regulates | pathway | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| Ferroptosis | regulates | pathway | 1.00 |
| AUTOPHAGY | therapeutic_target | gene | 1.00 |
| Carcinoma | therapeutic_target | disease | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| Autophagy | therapeutic_target | pathway | 1.00 |
| Cancer | contributes_to | disease | 1.00 |
| Ferroptosis | inhibits | pathway | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| STAT3 | activates | protein | 1.00 |
| INFLAMMATION | activates | phenotype | 1.00 |
| AUTOPHAGY | associated_with | pathway | 1.00 |
| PI3K | associated_with | gene | 1.00 |
| APOPTOSIS | inhibits | phenotype | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| STAT3 | regulates | gene | 1.00 |
| ERK | therapeutic_target | gene | 1.00 |
| PI3K | therapeutic_target | gene | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| INFLAMMATION | associated_with | gene | 1.00 |
| NF-ΚB | inhibits | gene | 1.00 |
| FERROPTOSIS | regulates | gene | 1.00 |
| FERROPTOSIS | inhibits | gene | 1.00 |
| PI3K | regulates | gene | 1.00 |
| AKT | regulates | gene | 1.00 |
| PI3K | activates | gene | 1.00 |
| PI3K | inhibits | gene | 1.00 |
| AKT | inhibits | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| MIRNAS | associated_with | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| ERK | inhibits | gene | 1.00 |
| EGFR | inhibits | gene | 1.00 |
| AKT1 | therapeutic_target | gene | 1.00 |
| EGFR | therapeutic_target | gene | 1.00 |
| BCL2 | therapeutic_target | gene | 1.00 |
| KRAS | therapeutic_target | gene | 1.00 |
| TNF | therapeutic_target | gene | 1.00 |
| EGFR | activates | gene | 1.00 |
| TP53 | therapeutic_target | gene | 1.00 |
| NF-ΚB | activates | gene | 1.00 |
| VEGF | therapeutic_target | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| TP53 | activates | gene | 1.00 |
| MITOPHAGY | activates | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| IL-6 | therapeutic_target | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| UBIQUITIN | regulates | gene | 1.00 |
| BECN1 | activates | gene | 1.00 |
| FERROPTOSIS | activates | gene | 1.00 |
| AGING | associated_with | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| MITOPHAGY | associated_with | gene | 1.00 |
| P53 | therapeutic_target | gene | 1.00 |
| BCL2 | inhibits | gene | 1.00 |
| BAX | inhibits | gene | 1.00 |
| P53 | inhibits | gene | 1.00 |
| TP53 | inhibits | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-11 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||