gene

P16

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P16: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

429Connections

4Hypotheses

4Analyses

50Outgoing

50Incoming

0Experiments

5Debates

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🧬 Gene Info

Gene Symbol	P16
Primary Expression	Ca1, Thalamus, Hypothalamus
Pathways	Cell Cycle, Dna Methylation, Angiogenesis, Histone Modification, Epigenetic
GeneCards	P16
Human Protein Atlas	P16
Associated Diseases	Aging, ALS, Alzheimer, Cancer, Epilepsy, glioblastoma
Interactions	ACETYL-COA, Actin, AGING, AKT, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections	425 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

CEP164 — Centrosomal Protein 164

gene · 1460 words

→

Pathway Diagram

graph TD
    P16["P16"]
    Senescence{"Senescence"}
    P16 -->|"activates"| Senescence
    Aging{"Aging"}
    P16 -->|"activates"| Aging
    Als{"Als"}
    P16 -->|"therapeutic_target"| Als
    Cancer{"Cancer"}
    P16 -->|"therapeutic_target"| Cancer
    AGING(["AGING"])
    AGING -->|"activates"| P16
    ERK(["ERK"])
    ERK -->|"activates"| P16
    CDKN2A(["CDKN2A"])
    CDKN2A -.->|"inhibits"| P16
    GENES(["GENES"])
    GENES -.->|"inhibits"| P16
    style P16 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#e0e0e0

Outgoing (271)

Target	Relation	Type	Str
Senescence	activates	disease	0.95
SENESCENCE	associated_with	gene	0.90
Aging	activates	disease	0.85
Als	therapeutic_target	disease	0.85
High-Grade Serous Ovarian Cancer	biomarker_for	disease	0.85
Cancer	therapeutic_target	disease	0.75
Tumor	therapeutic_target	disease	0.75
Senescence	therapeutic_target	disease	0.75
Tumor	inhibits	disease	0.75
Senescence	inhibits	disease	0.75
RB1	regulates	protein	0.70
P21	regulates	gene	0.70
Cell Cycle	activates	pathway	0.70
AKT	activates	gene	0.70
senescent microglia	biomarker_for	cell_type	0.70
DNA	therapeutic_target	gene	0.70
glioblastoma	associated_with	disease	0.70
OPC senescence	activates	phenotype	0.70
Aging	associated_with	disease	0.65
Breast Cancer	contributes_to	disease	0.65
Tumor	associated_with	disease	0.65
Ataxia	activates	disease	0.65
ALS	biomarker_for	disease	0.65
ALS	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
ALS	regulates	disease	0.65
Als	inhibits	disease	0.65
Inflammation	regulates	disease	0.65
Pulmonary Fibrosis	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Fibrosis	inhibits	disease	0.65
Senescence	biomarker_for	disease	0.65
Aging	treats	disease	0.65
Senescence	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Fibrosis	activates	disease	0.65
Cancer	associated_with	disease	0.65
Sarcopenia	treats	disease	0.65
Cancer	activates	disease	0.65
Carcinoma	activates	disease	0.65
Ms	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Cancer	biomarker_for	disease	0.65
Als	treats	disease	0.65
Ms	activates	disease	0.65
Tumor	expressed_in	disease	0.65
Pancreatic Cancer	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Obesity	activates	disease	0.65

Incoming (158)

Source	Relation	Type	Str
GENES	inhibits	gene	0.70
CDKN2A	inhibits	gene	0.70
ERK	activates	gene	0.70
P53	activates	gene	0.70
AGING	activates	gene	0.70
PI3K	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
P21	activates	gene	0.60
GENES	activates	gene	0.60
CYP2E1	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
PI3K	activates	gene	0.60
GAL	activates	gene	0.60
AGING	regulates	gene	0.60
CANCER	regulates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
P53	therapeutic_target	gene	0.60
IL-6	therapeutic_target	gene	0.60
CHONDROCYTE APOPTOSIS	therapeutic_target	gene	0.60
INFLAMMATION	activates	gene	0.60
ROS	activates	gene	0.60
ATM	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
ACETYL-COA	activates	gene	0.60
BNIP3	activates	gene	0.60
DNA	activates	gene	0.60
ASTROCYTES	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
AGING	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
OVERVIEW	associated_with	gene	0.60
SOX10	associated_with	gene	0.60
NF1	associated_with	gene	0.60
CDKN2A	expressed_in	gene	0.60
PARKINSON	activates	gene	0.60
AMYLOID	activates	gene	0.60
IL-6	regulates	gene	0.60
RNA	inhibits	gene	0.60
IL1B	activates	gene	0.60
IL18	activates	gene	0.60
TNF	activates	gene	0.60
CCL5	associated_with	gene	0.60
AND	regulates	gene	0.60
CYTOKINES	activates	gene	0.60
PTEN	therapeutic_target	gene	0.60
P21	inhibits	gene	0.60
TERC	regulates	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
p16^INK4a-CCF Axis as Senolytic Timing Biomarker	0.805	molecular-biology	What is the optimal therapeutic window t
Dasatinib plus Quercetin Senolytic Clearance of p16Ink4a-Hig	0.680	neurodegeneration	-
Timed Senolytic Therapy Eliminates p16^Ink4a/p21^Cip1-Senesc	0.564	neuroinflammation	What molecular mechanisms drive the tran
Selective Microglial Senescence Targeting via P16INK4A-Guide	0.000	-	Senescent cell clearance as neurodegener

Mentioning Analyses (4)

Scientific analyses that reference this entity

What specific gene expression signatures in aging mouse brain predict human AD v

neurodegeneration | 2026-04-12 | 0 hypotheses

Can P16INK4A expression reliably distinguish harmful from beneficial senescent m

neurodegeneration | 2026-04-11 | 0 hypotheses

How can senescent microglia be molecularly distinguished from beneficial activat

neurodegeneration | 2026-04-06 | 7 hypotheses Top: 0.720

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 15 hypotheses Top: 0.822

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (1)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
UNC93B1 promotes pancreatic cancer progression through modulation of cGAS-STING [PMID:41716413]	Yang H, Li Y, Su J, Zhang H, Zhu W et al	Front Immunol	2026	0

Debates (5)

Multi-agent debates referencing this entity

Hypothesis debate: SASP-Mediated Complement Cascade Amplification

closed · Rounds: 4 · Score: 0.40 · 2026-04-27

The debate revealed that microglial senescence markers are poorly defined compar

closed · Rounds: 4 · Score: 0.72 · 2026-04-22

The debate proposed P16INK4A-guided targeting but the Skeptic noted microglia ex

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

The debate was structured to identify aging-neurodegeneration mechanisms using A

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

closed · Rounds: 4 · Score: 0.89 · 2026-04-06

Related Research

Hypotheses and analyses mentioning P16 in their description or question text

No additional research found