Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IFN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
IFN is a concept in neurodegeneration research. Key relationships include: activates, interacts with, inhibits. Associated with AD, ALI, ALS. Connected to 702 entities in the SciDEX knowledge graph.
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| Name | IFN |
| Key Genes/Proteins | ACSL4, ACSL4 expression, Actin, AGING, AHR, AIM2 |
| Related Diseases | AD, aging, Aging, ALI |
| Related Pathways | Adaptive Immunity, Akt |
| Linked Hypotheses | 3 hypotheses |
Knowledge base pages for this entity
graph TD
IFN["IFN"]
IFN -->|"inhibits"| Tumor["Tumor"]
IFN -->|"inhibits"| Cancer["Cancer"]
IFN -->|"interacts"| ALS["ALS"]
IFN -->|"interacts"| Fibrosis["Fibrosis"]
IFN -->|"activates"| Inflammation["Inflammation"]
IFN -->|"activates"| Aging["Aging"]
IFN -->|"inhibits"| Neuroinflammation["Neuroinflammation"]
STING["STING"] -->|"activates"| IFN
CGAS["CGAS"] -->|"activates"| IFN
IRF3["IRF3"] -->|"activates"| IFN
DNA["DNA"] -->|"activates"| IFN
PARP1["PARP1"] -->|"inhibits"| IFN
ROS["ROS"] -->|"interacts"| IFN
RICTOR["RICTOR"] -->|"interacts"| IFN
MTOR["MTOR"] -->|"interacts"| IFN
MAP1LC3A["MAP1LC3A"] -->|"interacts"| IFN
LC3["LC3"] -->|"interacts"| IFN| Target | Relation | Type | Str |
|---|---|---|---|
| IFN | encodes | protein | 0.00 |
| Aging | activates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Infection | activates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Innate Immunity | activates | pathway | 1.00 |
| Immune Response | activates | pathway | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| Als | therapeutic_target | disease | 0.95 |
| Als | inhibits | disease | 0.95 |
| unfolded protein response | participates_in | pathway | 0.90 |
| neuroinflammation | activates | disease | 0.90 |
| neural stem cells | activates | cell_type | 0.90 |
| microglia | inhibits | cell_type | 0.90 |
| cGAS-STING | participates_in | pathway | 0.90 |
| microglia | activates | cell_type | 0.90 |
| oxidative stress response | participates_in | pathway | 0.90 |
| Toll-Like Receptor | activates | pathway | 0.90 |
| Mtor | activates | pathway | 0.90 |
| Apoptosis | activates | pathway | 0.90 |
| Inflammation | regulates | disease | 0.85 |
| Autoimmune | therapeutic_target | disease | 0.85 |
| Inflammation | inhibits | disease | 0.85 |
| Cancer | inhibits | disease | 0.85 |
| Inflammation | associated_with | disease | 0.85 |
| Carcinoma | activates | disease | 0.85 |
| Tumor | therapeutic_target | disease | 0.85 |
| Neurodegeneration | activates | disease | 0.85 |
| neurons | activates | cell_type | 0.80 |
| NF-kB signaling | participates_in | pathway | 0.80 |
| LRRK2 | interacts_with | protein | 0.80 |
| ventriculomegaly | causes | disease | 0.80 |
| MIA | causes | gene | 0.80 |
| AQP4 | modulates | protein | 0.80 |
| cGAS-STING | activates | pathway | 0.80 |
| IFNGR | binds | protein | 0.80 |
| T cells | expressed_in | cell_type | 0.80 |
| microglia | associated_with | cell_type | 0.80 |
| neurons | expressed_in | cell_type | 0.80 |
| endothelial cells | expressed_in | cell_type | 0.80 |
| stem cells | expressed_in | cell_type | 0.80 |
| MICROGLIA | activates | gene | 0.80 |
| Apoptosis | inhibits | pathway | 0.80 |
| Immune Response | therapeutic_target | pathway | 0.80 |
| Tgf-Β | activates | pathway | 0.80 |
| Parkinson | therapeutic_target | disease | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| IFN | encodes | gene | 0.00 |
| INFLAMMATION | activates | gene | 1.00 |
| P62 | activates | gene | 1.00 |
| DNA | activates | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| IL-6 | activates | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| TNF-Α | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| STING | activates | protein | 1.00 |
| CGAS | activates | protein | 1.00 |
| GENES | activates | gene | 1.00 |
| NF-ΚB | activates | gene | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| CGAS-STING | activates | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| MICROGLIA | activates | gene | 1.00 |
| IRF3 | activates | protein | 0.94 |
| APOPTOSIS | activates | gene | 0.90 |
| AKT | activates | gene | 0.90 |
| NFKB | interacts_with | pathway | 0.80 |
| DNA | disrupts | gene | 0.80 |
| TLR4 | activates | gene | 0.80 |
| APOPTOSIS | inhibits | gene | 0.80 |
| DNA | interacts_with | gene | 0.80 |
| IL-6 | inhibits | gene | 0.80 |
| CYTOKINES | associated_with | gene | 0.80 |
| TNF | inhibits | gene | 0.80 |
| CYTOKINES | inhibits | gene | 0.80 |
| MTORC1 | activates | gene | 0.80 |
| CD8 | activates | gene | 0.80 |
| NEURODEGENERATION | activates | gene | 0.80 |
| MITOCHONDRIA | activates | gene | 0.80 |
| ROS | activates | gene | 0.80 |
| TBK1 | activates | gene | 0.80 |
| ASTROCYTES | activates | gene | 0.70 |
| DNA | expressed_in | gene | 0.70 |
| CCL5 | activates | gene | 0.70 |
| NEURODEGENERATIVE DISEASES | activates | gene | 0.70 |
| TNF-Α | inhibits | gene | 0.70 |
| BAX | activates | gene | 0.70 |
| ATP | interacts_with | gene | 0.70 |
| SQSTM1 | activates | gene | 0.70 |
| DNA | regulates | gene | 0.70 |
| PARKINSON'S DISEASE | therapeutic_target | gene | 0.70 |
| MITOCHONDRIAL DNA | activates | gene | 0.70 |
| STAT3 | activates | gene | 0.70 |
| MTOR | activates | gene | 0.70 |
| GENES | associated_with | gene | 0.70 |
| MTDNA | activates | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TBK1 Loss-of-Function Amplifies C1q-Mediated Synapse Elimina | 0.724 | neurodegeneration | How do the seven novel ALS genes functio |
| Microglial IFN-β Priming of Motor Neuron cGAS/STING Amplific | 0.720 | neurodegeneration | What determines the specificity of TDP-4 |
| STING Antagonism Prevents Acute-to-Chronic Neuroinflammation | 0.601 | neuroinflammation | What molecular mechanisms drive the tran |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 19 hypotheses Top: 0.891
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Endothelium-specific TBK1 knockdown in atherosclerosis model | validation | atherosclerosis | 0.900 | 0.00 | endothelium-specific TBK1 knoc | proposed | N/A |
| TBK1-PAK1IP1-PAK1 signaling pathway analysis | exploratory | atherosclerosis | 0.900 | 0.00 | endothelial cells | proposed | N/A |
| GSK8612 treatment in atherosclerosis model | validation | atherosclerosis | 0.800 | 0.00 | atherosclerosis mouse model | proposed | N/A |
| LC-MS/Western blot analysis of TBK1 in atherosclerotic arteries | exploratory | atherosclerosis | 0.800 | 0.00 | mouse and human arteries with | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Restricting intracellular Salmonella proliferation by coordinating p-TBK1 mediat [PMID:40660474] | Li J, Yang Y, Ge Y, Zhang X, Liu H et al | Autophagy | 2026 | 0 |
| Aberrant STING signalling promotes endothelial dysfunction and neurovascular inj [PMID:41419617] | Qin X, Chen S, Sun Y, Ma Z, Niu C et al. | Diabetologia | 2026 | 0 |
| TBK1 orchestrates autophagy and endo-lysosomal pathways in human neurons. [PMID:41485128] | Mordes DA, Smeyers J | Autophagy | 2026 | 0 |
| Dynamic regulation of TBK1 lactylation shapes antiviral immune responses. [PMID:41530535] | Xie Y, Zhang Y, Peng W, Zhang L, Hu Z et | Cell Mol Immunol | 2026 | 0 |
| RIG-I Mediated Neuron-Specific IFN Type 1 Signaling in FUS-ALS Induces Neurodege [PMID:41603250] | Naumann M, Wierschin TM, Kretschmer S, D | Adv Sci (Weinh) | 2026 | 0 |
| BTK inhibition suppresses neuroinflammation and neurodegeneration in amyotrophic [PMID:41710977] | Liu Q, Zhang X, Wang L, Chen H, Wang G e | Brain | 2026 | 0 |
| Systematic Review: Porphyromonas gingivalis Outer Membrane Vesicles From Pathoge [PMID:41980468] | Li Z, Luo C, Wen P, Zou T, Jin Z et al. | Int Dent J | 2026 | 0 |
| TBK1 orchestrates autophagy and endo-lysosomal pathways in human neurons. [PMID:41485128] | Mordes DA, Smeyers J | Autophagy | 2026 | 0 |
| BTK inhibition suppresses neuroinflammation and neurodegeneration in amyotrophic [PMID:41710977] | Liu Q, Zhang X, Wang L, Chen H, Wang G, | Brain : a journal of neurology | 2026 | 0 |
| RIG-I Mediated Neuron-Specific IFN Type 1 Signaling in FUS-ALS Induces Neurodege [PMID:41603250] | Naumann M, Wierschin TM, Kretschmer S, D | Advanced science (Weinheim, Ba | 2026 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.57 · 2026-04-28
closed · Rounds: 4 · Score: 0.12 · 2026-04-27
closed · Rounds: 4 · Score: 0.42 · 2026-04-27
closed · Rounds: 4 · Score: 0.48 · 2026-04-27
closed · Rounds: 4 · Score: 0.47 · 2026-04-27
closed · Rounds: 4 · Score: 0.52 · 2026-04-27
closed · Rounds: 4 · Score: 0.72 · 2026-04-27
closed · Rounds: 4 · Score: 0.90 · 2026-04-03
Hypotheses and analyses mentioning IFN in their description or question text
No additional research found