concept

RUNX2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RUNX2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

247Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

RUNX2 is a concept in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, Aging, Als. Connected to 117 entities in the SciDEX knowledge graph.

View on Wiki →

💡 Concept Info

Name	RUNX2
Key Genes/Proteins	PIEZO1, GENES, VEGF
Related Diseases	aortic valve calcification, H3K14la, H3K9la, Als, Cancer
Related Pathways	Notch, Wnt, Tgf-Β

Wiki Pages (10)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    RUNX2["RUNX2"]
    RUNX2 -->|"activates"| Als["Als"]
    RUNX2 -->|"activates"| Arthritis["Arthritis"]
    RUNX2 -->|"expressed in"| Aging["Aging"]
    RUNX2 -->|"activates"| Ms["Ms"]
    RUNX2 -->|"activates"| ALS["ALS"]
    RUNX2 -->|"activates"| PDGFRB["PDGFRB"]
    PRKCH["PRKCH"] -->|"regulates"| RUNX2
    PIEZO1["PIEZO1"] -->|"activates"| RUNX2
    VEGFB["VEGFB"] -->|"activates"| RUNX2
    VEGF["VEGF"] -->|"activates"| RUNX2
    FGF2["FGF2"] -->|"activates"| RUNX2
    YAP["YAP"] -->|"activates"| RUNX2
    GLS1["GLS1"] -->|"activates"| RUNX2
    RANK["RANK"] -->|"regulates"| RUNX2
    RANKL["RANKL"] -->|"regulates"| RUNX2
    ANGPT1["ANGPT1"] -->|"activates"| RUNX2

Outgoing (150)

Target	Relation	Type	Str
aortic valve calcification	promotes	phenotype	0.85
Osteogenic Differentiation	involved_in	process	0.85
Osteogenesis	promotes	process	0.85
Als	regulates	disease	0.75
Cancer	regulates	disease	0.75
GENES	activates	gene	0.70
PIEZO1	activates	gene	0.70
VEGF	activates	gene	0.70
Notch	regulates	pathway	0.70
Wnt	regulates	pathway	0.70
Tgf-Β	regulates	pathway	0.70
Hedgehog	regulates	pathway	0.70
CYTOKINES	regulates	gene	0.70
CANCER	regulates	gene	0.70
Als	activates	disease	0.65
Arthritis	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Aging	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Ms	activates	disease	0.65
Ms	regulates	disease	0.65
ALS	activates	disease	0.65
ALS	regulates	disease	0.65
Tumor	regulates	disease	0.65
Prostate Cancer	regulates	disease	0.65
Cardiovascular	inhibits	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Autoimmune	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Ms	expressed_in	disease	0.65
Diabetes	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Diabetes	biomarker_for	disease	0.65
Cancer	biomarker_for	disease	0.65
PDGFRB	activates	gene	0.60
ANGPT1	activates	gene	0.60
BMP2	activates	gene	0.60
Angiogenesis	activates	pathway	0.60
Wnt	associated_with	pathway	0.60
VEGFB	activates	gene	0.60
YAP	activates	gene	0.60
BMAL1	interacts_with	gene	0.60
ARNT	expressed_in	gene	0.60
Akt	inhibits	pathway	0.60
Mapk	expressed_in	pathway	0.60
Tgf-Β	expressed_in	pathway	0.60
P38	associated_with	gene	0.60
Akt	associated_with	pathway	0.60
Mapk	associated_with	pathway	0.60
Pi3K	associated_with	pathway	0.60

Incoming (97)

Source	Relation	Type	Str
Osteoking	upregulates	drug	0.90
H3K14la	associated_with	phenotype	0.85
PIEZO1	activates	protein	0.80
H3K9la	regulates	phenotype	0.80
BMP2	inhibits	gene	0.70
VEGFB	activates	gene	0.60
VEGF	activates	gene	0.60
FGF2	activates	gene	0.60
YAP	activates	gene	0.60
GLS1	activates	gene	0.60
RANK	regulates	gene	0.60
RANKL	regulates	gene	0.60
ATF4	associated_with	gene	0.60
ANGPT1	activates	gene	0.60
BMP2	activates	gene	0.60
PDGFRB	activates	gene	0.60
RANK	therapeutic_target	gene	0.60
RANKL	therapeutic_target	gene	0.60
AGING	expressed_in	gene	0.60
AKT	inhibits	gene	0.60
TNF	interacts_with	gene	0.60
RHOA	expressed_in	gene	0.60
ERK	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
AKT	associated_with	gene	0.60
DRP1	activates	gene	0.60
MFN1	activates	gene	0.60
OPA1	activates	gene	0.60
LARS2	activates	gene	0.60
MFN2	activates	gene	0.60
HIPPO	regulates	gene	0.60
TAZ	associated_with	gene	0.60
PTEN	inhibits	gene	0.60
PINK1	inhibits	gene	0.60
MITOPHAGY	inhibits	gene	0.60
MIRNAS	regulates	gene	0.60
DLAT	inhibits	gene	0.60
AND	activates	gene	0.60
AND	interacts_with	gene	0.60
BMAL1	interacts_with	gene	0.60
MAPK	expressed_in	gene	0.60
JNK	inhibits	gene	0.60
GENES	associated_with	gene	0.60
JNK	associated_with	gene	0.60
ATM	associated_with	gene	0.60
AND	associated_with	gene	0.60
HDAC9	associated_with	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
BAX	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

RUNX2

Understanding Entity Pages

Summary

Wiki Pages (10)

CBS/PSP Genetic Architecture

LARS2 — Leucyl-tRNA Synthetase 2, Mitochondrial

Chondrogenesis (Neural)

WWTR1 (TAZ) — WW Domain Containing Transcription Regulator 1, Hippo Effector

DDX5 Gene

TGFBI

ADAMTS4 Gene

ADAMTS-4 Protein