gene

LGALS3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LGALS3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

953Connections

4Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

LGALS3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 455 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	LGALS3
Full Name	Lectin, Galactoside-Binding, Soluble, 3
Chromosome	14
Function	The LGALS3 gene encodes Lectin, Galactoside-Binding, Soluble, 3, a protein expressed in various brain regions including the cerebral cortex, hippocampus, basal ganglia, and cerebellum.
Primary Expression	activated microglia and plays complex roles in neuroinflammation - both promoting and resolving inflammatory responses
Pathways	Amyloid, Lipid Metabolism
UniProt ID	P17931
Ensembl ID	ENSG00000131981
OMIM	153619
GeneCards	LGALS3
Human Protein Atlas	LGALS3
Associated Diseases	AD, ALI, Als, Alzheimer, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	rapamycin
Interactions	ABCD3, ACTB, ALS, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE
SciDEX Hypotheses	Galectin-3 deletion attenuates NLRP3 inflammasome Galectin-3 as Damage-Sensor Scaffold for Multimeri Lectin-Mediated Autophagy Enhancers (+1 more)
KG Connections	944 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: LGALS3 — AlphaFold P17931 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

LGALS3 Gene

gene · 953 words

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Pathway Diagram

graph TD
    LGALS3["LGALS3
(Galectin-3)"]:::central
    
    LGALS3 -->|"interacts_with"| Dementia["Dementia"]
    LGALS3 -->|"interacts_with"| Cardiovascular["Cardiovascular
Disease"]
    LGALS3 -->|"interacts_with"| Als["ALS"]
    LGALS3 -->|"interacts_with"| Alzheimer["Alzheimer's
Disease"]
    LGALS3 -->|"interacts_with"| Parkinson["Parkinson's
Disease"]
    LGALS3 -->|"interacts_with"| Ms["Multiple
Sclerosis"]
    LGALS3 -->|"associated_with"| AmyotrophicLateralSclerosis["Amyotrophic
Lateral Sclerosis"]
    LGALS3 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    LGALS3 -->|"associated_with"| Ataxia["Ataxia"]
    LGALS3 -->|"associated_with"| Huntington["Huntington's
Disease"]
    LGALS3 -->|"therapeutic_target"| AlsTarget["ALS
Treatment"]
    LGALS3 -->|"therapeutic_target"| MsTarget["MS
Treatment"]
    
    classDef central fill:#FF6B6B,stroke:#C92A2A,stroke-width:3px,color:#e0e0e0,font-size:14px
    classDef disease fill:#4ECDC4,stroke:#0A8A80,stroke-width:2px,color:#e0e0e0
    classDef process fill:#FFE66D,stroke:#D4A600,stroke-width:2px,color:#e0e0e0
    classDef target fill:#95E1D3,stroke:#38A169,stroke-width:2px,color:#e0e0e0
    
    class Dementia,Cardiovascular,Als,Alzheimer,Parkinson,Ms,AmyotrophicLateralSclerosis,Ataxia,Huntington disease
    class Neurodegeneration process
    class AlsTarget,MsTarget target

Outgoing (557)

Target	Relation	Type	Str
LGALS3	encodes	protein	0.00
ds-f2c28aed24a7	provides_data_for	dataset	1.00
lysosomal damage	associated_with	process	0.95
neuroinflammation	drives	process	0.90
microglial activation	drives	process	0.90
amyloid-beta plaque clearance	promotes	process	0.88
Amyloid-Beta Plaque Clearance	mediates	process	0.87
TREM2	interacts_with	protein	0.85
Huntington's Disease	implicated_in	disease	0.85
TLR4	interacts_with	protein	0.84
Psoriasis	associated_with	disease	0.80
neural stem cells	activates	cell_type	0.80
oxidative stress response	participates_in	pathway	0.80
ciliary signaling	regulates	pathway	0.75
dopaminergic signaling	regulates	pathway	0.75
Neurodegeneration	activates	disease	0.75
Als	associated_with	disease	0.75
GENES	activates	gene	0.70
MCOLN1	interacts_with	gene	0.70
TFEB	interacts_with	gene	0.70
ALS	activates	disease	0.70
NEURODEGENERATION	activates	gene	0.70
tau_vesicles	targets	cellular_component	0.70
Parkinson's disease	activates	disease	0.70
PPP3CB	associated_with	protein	0.70
neural stem cells	interacts_with	cell_type	0.70
autophagy pathway	participates_in	pathway	0.70
autophagy_pathway	modulates	pathway	0.70
autophagy	regulates	process	0.70
Als	therapeutic_target	disease	0.65
Huntington	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Ataxia	associated_with	disease	0.65
Cancer	inhibits	disease	0.65
Ms	activates	disease	0.65
Fibrosis	activates	disease	0.65
Stroke	contributes_to	disease	0.65
ALS	associated_with	disease	0.65
Cancer	contributes_to	disease	0.65
Ftd	interacts_with	disease	0.65
Alzheimer	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Als	activates	disease	0.65

Incoming (396)

Source	Relation	Type	Str
LGALS3	encodes	gene	0.00
ds-f2c28aed24a7	data_in	dataset	1.00
berbamine hydrochloride	inhibits	drug	0.95
APOE4	regulates	gene	0.85
CTSB	interacts_with	gene	0.70
DNA	activates	gene	0.70
ATG	activates	gene	0.70
MFN1	interacts_with	gene	0.60
DDIT3	activates	entity	0.60
DNM1L	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
STIP1	associated_with	gene	0.60
GBA	interacts_with	gene	0.60
HIF1A	interacts_with	gene	0.60
ABCD3	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
RHOT1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
SESN2	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
PPP3CB	associated_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
TFEB	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
HSPB8	associated_with	gene	0.60
P62	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
STX4	associated_with	gene	0.60
LDLR	associated_with	gene	0.60
APOA2	associated_with	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Galectin-3 deletion attenuates NLRP3 inflammasome activation	0.625	neuroscience	Lysosomal dysfunction and cathepsin leak
Galectin-3 as Damage-Sensor Scaffold for Multimeric Cross-Se	0.455	neurodegeneration	Protein aggregation cross-seeding across
Lectin-Mediated Autophagy Enhancers	0.455	neurodegeneration	Do tau-containing vesicles exhibit uniqu
Galectin-3/TREM2 Competitive Inhibition Therapy	0.000	-	Immune atlas neuroinflammation analysis

Mentioning Analyses (1)

Scientific analyses that reference this entity

Do tau-containing vesicles exhibit unique surface glycosylation patterns that di

neurodegeneration | 2026-04-09 | 7 hypotheses Top: 0.455

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Do tau-containing vesicles exhibit unique surface glycosylation patterns that di

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Related Research

Hypotheses and analyses mentioning LGALS3 in their description or question text

No additional research found