gene

LGALS3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LGALS3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

957Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

LGALS3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 455 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	LGALS3
Full Name	Lectin, Galactoside-Binding, Soluble, 3
Chromosome	14
Function	The LGALS3 gene encodes Lectin, Galactoside-Binding, Soluble, 3, a protein expressed in various brain regions including the cerebral cortex, hippocampus, basal ganglia, and cerebellum.
Primary Expression	activated microglia and plays complex roles in neuroinflammation - both promoting and resolving inflammatory responses
Pathways	Amyloid, Lipid Metabolism
UniProt ID	P17931
Ensembl ID	ENSG00000131981
OMIM	153619
GeneCards	LGALS3
Human Protein Atlas	LGALS3
Associated Diseases	AD, ALI, Als, Alzheimer, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	rapamycin
Interactions	ABCD3, ACTB, ALS, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE
KG Connections	949 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: LGALS3 — AlphaFold P17931 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

LGALS3 Gene

gene · 953 words

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Pathway Diagram

graph TD
    LGALS3["<b>LGALS3</b><br/>(Galectin-3)"]:::central
    
    LGALS3 -->|"interacts_with"| Dementia["Dementia"]
    LGALS3 -->|"interacts_with"| Cardiovascular["Cardiovascular<br/>Disease"]
    LGALS3 -->|"interacts_with"| Als["ALS"]
    LGALS3 -->|"interacts_with"| Alzheimer["Alzheimer's<br/>Disease"]
    LGALS3 -->|"interacts_with"| Parkinson["Parkinson's<br/>Disease"]
    LGALS3 -->|"interacts_with"| Ms["Multiple<br/>Sclerosis"]
    LGALS3 -->|"associated_with"| AmyotrophicLateralSclerosis["Amyotrophic<br/>Lateral Sclerosis"]
    LGALS3 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    LGALS3 -->|"associated_with"| Ataxia["Ataxia"]
    LGALS3 -->|"associated_with"| Huntington["Huntington's<br/>Disease"]
    LGALS3 -->|"therapeutic_target"| AlsTarget["ALS<br/>Treatment"]
    LGALS3 -->|"therapeutic_target"| MsTarget["MS<br/>Treatment"]
    
    classDef central fill:#FF6B6B,stroke:#C92A2A,stroke-width:3px,color:#e0e0e0,font-size:14px
    classDef disease fill:#4ECDC4,stroke:#0A8A80,stroke-width:2px,color:#e0e0e0
    classDef process fill:#FFE66D,stroke:#D4A600,stroke-width:2px,color:#e0e0e0
    classDef target fill:#95E1D3,stroke:#38A169,stroke-width:2px,color:#e0e0e0
    
    class Dementia,Cardiovascular,Als,Alzheimer,Parkinson,Ms,AmyotrophicLateralSclerosis,Ataxia,Huntington disease
    class Neurodegeneration process
    class AlsTarget,MsTarget target

Outgoing (560)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
lysosomal damage	associated_with	process	0.95
neuroinflammation	drives	process	0.90
microglial activation	drives	process	0.90
amyloid-beta plaque clearance	promotes	process	0.88
Amyloid-Beta Plaque Clearance	mediates	process	0.87
Huntington's Disease	implicated_in	disease	0.85
TREM2	interacts_with	protein	0.85
TLR4	interacts_with	protein	0.84
Psoriasis	associated_with	disease	0.80
oxidative stress response	participates_in	pathway	0.80
neural stem cells	activates	cell_type	0.80
dopaminergic signaling	regulates	pathway	0.75
ciliary signaling	regulates	pathway	0.75
Als	associated_with	disease	0.75
Neurodegeneration	activates	disease	0.75
NEURODEGENERATION	activates	gene	0.70
PPP3CB	binds	protein	0.70
neural stem cells	interacts_with	cell_type	0.70
GENES	activates	gene	0.70
autophagy pathway	participates_in	pathway	0.70
MCOLN1	interacts_with	gene	0.70
ALS	activates	disease	0.70
Parkinson's disease	activates	disease	0.70
TFEB	interacts_with	gene	0.70
Cancer	expressed_in	disease	0.65
Dementia	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Neuroblastoma	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Parkinson	regulates	disease	0.65
Ms	regulates	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Carcinoma	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
Stroke	activates	disease	0.65
Ischemia	activates	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
Als	inhibits	disease	0.65

Incoming (397)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
berbamine hydrochloride	inhibits	drug	0.95
APOE4	downregulates	gene	0.85
DNA	activates	gene	0.70
ATG	activates	gene	0.70
CTSB	interacts_with	gene	0.70
STIP1	associated_with	gene	0.60
DDIT3	interacts_with	gene	0.60
ABCD3	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
HIF1A	interacts_with	gene	0.60
CAPN1	therapeutic_target	gene	0.60
TTR	therapeutic_target	gene	0.60
DISC1	activates	entity	0.60
TPP1	associated_with	gene	0.60
TREH	associated_with	gene	0.60
STUB1	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
CAT	interacts_with	gene	0.60
GLA	associated_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
BECN1	associated_with	gene	0.60
ATG12	activates	gene	0.60
PPARGC1A	associated_with	gene	0.60
MCOLN1	associated_with	gene	0.60
BAG3	associated_with	gene	0.60
ABCD3	activates	entity	0.60
BAG3	activates	entity	0.60
CTSB	activates	entity	0.60
GAPDH	activates	entity	0.60
GLA	activates	entity	0.60
HSPA8	activates	entity	0.60
HSPB8	activates	entity	0.60
LAMP1	activates	entity	0.60
CALCINEURIN	activates	gene	0.60
TDP-43	associated_with	gene	0.60
APOE4	associated_with	gene	0.60
ATG10	activates	gene	0.60
OPTN	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity