gene

RHOA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RHOA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

358Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

RHOA is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, interacts with. Associated with ALS, Aging, Als. Connected to 157 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RHOA
Full Name	Ras Homolog Family Member A
Chromosome	3p21.31
Function	encodes a small GTP-binding protein that functions as a molecular switch, cycling between an active GTP-bound state and an inactive GDP-bound state.
Molecular Weight	~22 kDa
Amino Acids	191 aa
Pathways	Akt, Angiogenesis, Apoptosis, Complement, Egfr Signaling
UniProt ID	[P61586](https://www.uniprot.org/uniprotkb/P61586/entry)
Ensembl ID	ENSG00000167553
GeneCards	RHOA
Human Protein Atlas	RHOA
Associated Diseases	Alzheimer, cancer, Dementia, Lung Cancer, Ms, neurodevelopmental disorders
Interactions	ACVR1, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA
SciDEX Hypotheses	Complement-Independent SPP1 Signaling Disruption
KG Connections	354 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RHOA Gene — Ras Homolog Family Member A

gene · 2670 words

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Pathway Diagram

graph TD
    RHOA["RHOA"] -->|"activates"| Aging["Aging"]
    RHOA["RHOA"] -->|"activates"| Ms["Ms"]
    RHOA["RHOA"] -->|"activates"| Als["Als"]
    RHOA["RHOA"] -->|"activates"| Osteoporosis["Osteoporosis"]
    RHOA["RHOA"] -->|"regulates"| Alzheimer["Alzheimer"]
    RHOA["RHOA"] -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    EPHB4["EPHB4"] -->|"activates"| RHOA["RHOA"]
    ARF1["ARF1"] -.->|"inhibits"| RHOA["RHOA"]
    APP_PS1["APP/PS1"] -->|"regulates"| RHOA["RHOA"]
    P62["P62"] -->|"regulates"| RHOA["RHOA"]
    style RHOA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (243)

Target	Relation	Type	Str
Alzheimer's disease	associated_with	disease	0.85
osteoblast	involved_in	cell_type	0.75
autism spectrum disorder	associated_with	disease	0.75
Als	inhibits	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
Als	activates	disease	0.75
neurodevelopmental disorders	implicated_in	disease	0.70
Dementia	therapeutic_target	disease	0.65
Alzheimer	inhibits	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Autism	activates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Osteoporosis	activates	disease	0.65
Aging	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
ALS	expressed_in	disease	0.65
Neuropathy	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Neurodegeneration	activates	disease	0.65
Cancer	expressed_in	disease	0.65
Gastric Cancer	activates	disease	0.65
Tumor	regulates	disease	0.65
Dementia	causes	disease	0.65
Alzheimer	causes	disease	0.65
Vascular Dementia	causes	disease	0.65
ALS	regulates	disease	0.65
Tumor	associated_with	disease	0.65
Huntington	activates	disease	0.65
Alzheimer	activates	disease	0.65
Parkinson	activates	disease	0.65
Vascular Dementia	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Autism	expressed_in	disease	0.65
Alzheimer	regulates	disease	0.65
Fibrosis	inhibits	disease	0.65
Tumor	interacts_with	disease	0.65
Lymphoma	interacts_with	disease	0.65
Nephropathy	activates	disease	0.65
Aging	interacts_with	disease	0.65
Ms	activates	disease	0.65
Ms	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Als	interacts_with	disease	0.65
Aging	activates	disease	0.65

Incoming (115)

Source	Relation	Type	Str
ARHGEF2	activates	gene	0.90
Icariin	upregulates	compound	0.85
EPHB4	regulates	gene	0.80
P75NTR	activates	protein	0.80
AGING	expressed_in	gene	0.60
RNA	activates	gene	0.60
AXON	inhibits	gene	0.60
DEMENTIA	causes	gene	0.60
AND	activates	gene	0.60
WNT	activates	gene	0.60
MAPK	activates	gene	0.60
RAS	activates	gene	0.60
CYTOKINES	activates	gene	0.60
IL-1	activates	gene	0.60
RAS	associated_with	gene	0.60
COMPLEMENT	activates	gene	0.60
EGFR	associated_with	gene	0.60
APP/PS1	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
LYSOSOMAL BIOGENESIS	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
GENES	activates	gene	0.60
MYELIN	inhibits	gene	0.60
MAGI2	activates	gene	0.60
PRRG4	activates	gene	0.60
MAPK	regulates	gene	0.60
ANXA5	expressed_in	gene	0.60
CCND1	expressed_in	gene	0.60
ROCK1	activates	gene	0.60
LAMP1	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
AKT	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
MAPK1	associated_with	gene	0.60
BNIP3	regulates	gene	0.60
PI3K	activates	gene	0.60
PIEZO1	activates	gene	0.60
RAC1	inhibits	gene	0.60
LAMP1	inhibits	gene	0.60
HDAC6	inhibits	gene	0.60
PIK3CA	interacts_with	gene	0.60
RANKINGS	interacts_with	gene	0.60
RAC1	interacts_with	gene	0.60
MAPK1	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
CBL	interacts_with	gene	0.60
AKT	interacts_with	gene	0.60
BCL2L1	associated_with	gene	0.60
MAP2K1	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Complement-Independent SPP1 Signaling Disruption	0.000	-	What molecular mechanisms mediate SPP1-i

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

neuroinflammation | 2026-04-15 | 13 hypotheses Top: 0.752

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

closed · Rounds: 5 · Score: 0.95 · 2026-04-15

Related Research

Hypotheses and analyses mentioning RHOA in their description or question text

No additional research found