concept

CASPASE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASPASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

809Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	CASPASE

Pathway Diagram

graph TD
    CASPASE["CASPASE"]
    style CASPASE fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    CASPASE -->|"activates"| PANoptosis["PANoptosis"]
    CASPASE -->|"cleaves"| GSDME([GSDME])
    CASPASE -->|"activates"| neurodegeneration["neurodegeneration"]
    CASPASE -->|"activates"| IL1B([IL1B])
    CASPASE -->|"regulates"| Fibrosis["Fibrosis"]
    CASPASE -->|"interacts"| Cancer["Cancer"]
    CASPASE -->|"interacts"| Als["Als"]
    CASPASE -.->|"inhibits"| Aging["Aging"]
    RIPK1([RIPK1]) -->|"interacts"| CASPASE
    PPARG([PPARG]) -->|"interacts"| CASPASE
    WNT([WNT]) -->|"regulates"| CASPASE
    TFEB([TFEB]) -->|"interacts"| CASPASE
    CFTR([CFTR]) -->|"regulates"| CASPASE
    RICTOR([RICTOR]) -->|"interacts"| CASPASE
    ROS([ROS]) -->|"regulates"| CASPASE
    GRB2([GRB2]) -->|"interacts"| CASPASE
    HSP70([HSP70]) -->|"interacts"| CASPASE
    STAT3([STAT3]) -->|"interacts"| CASPASE

Outgoing (207)

Target	Relation	Type	Str
PANoptosis	activates	process	0.92
neurodegeneration	activates	process	0.70
Aging	inhibits	disease	0.60
Lymphoma	associated_with	disease	0.60
Cancer	inhibits	disease	0.60
Als	inhibits	disease	0.60
Ischemia	inhibits	disease	0.60
Ferroptosis	activates	disease	0.60
Stroke	therapeutic_target	disease	0.60
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.60
Parkinson	therapeutic_target	disease	0.60
Als	therapeutic_target	disease	0.60
Neuroinflammation	therapeutic_target	disease	0.60
Als	expressed_in	disease	0.60
Glioblastoma	activates	disease	0.60
Alzheimer	inhibits	disease	0.60
Stroke	regulates	disease	0.60
Atherosclerosis	expressed_in	disease	0.60
Dementia	inhibits	disease	0.60
Anxiety	inhibits	disease	0.60
Pyroptosis	interacts_with	disease	0.60
Diabetes	activates	disease	0.60
Obesity	activates	disease	0.60
Stroke	activates	disease	0.60
Als	associated_with	disease	0.60
Neuroinflammation	associated_with	disease	0.60
Neurodegeneration	associated_with	disease	0.60
Pyroptosis	degrades	disease	0.60
Als	degrades	disease	0.60
Necroptosis	activates	disease	0.60
Aging	activates	disease	0.60
Depression	activates	disease	0.60
Neuroinflammation	inhibits	disease	0.60
Dementia	therapeutic_target	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Fibrosis	activates	disease	0.60
Pyroptosis	inhibits	disease	0.60
Ferroptosis	inhibits	disease	0.60
Necroptosis	inhibits	disease	0.60
Fibrosis	inhibits	disease	0.60
Hypertension	inhibits	disease	0.60
Pyroptosis	regulates	disease	0.60
Necroptosis	regulates	disease	0.60
Aging	encodes	disease	0.60
Neuroinflammation	expressed_in	disease	0.60
Traumatic Brain Injury	activates	disease	0.60
Neurodegeneration	expressed_in	disease	0.60
Alzheimer	associated_with	disease	0.60
Diabetes	regulates	disease	0.60
Depression	interacts_with	disease	0.60

Incoming (602)

Source	Relation	Type	Str
EHMT2	associated_with	gene	0.60
BAX	associated_with	gene	0.60
CASPASE3	associated_with	gene	0.60
APOPTOSIS	inhibits	gene	0.60
FOXO1	associated_with	gene	0.60
JUN	inhibits	gene	0.60
BCL-2	associated_with	gene	0.60
STING	activates	gene	0.60
CD68	expressed_in	gene	0.60
RNA	activates	gene	0.60
ANXA1	expressed_in	gene	0.60
CGAS-STING	activates	gene	0.60
AKT	activates	gene	0.60
P38	activates	gene	0.60
ERK	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
PKC	activates	gene	0.60
MAPK	activates	gene	0.60
EEF2	activates	gene	0.60
JNK	activates	gene	0.60
GSDME	degrades	gene	0.60
CD8	inhibits	gene	0.60
GASDERMIN	associated_with	gene	0.60
PYROPTOSIS	degrades	gene	0.60
PHAGOCYTOSIS	inhibits	gene	0.60
IL-17	activates	gene	0.60
MMP9	activates	gene	0.60
BAX	activates	gene	0.60
S100A8	activates	gene	0.60
S100A9	activates	gene	0.60
MTOR	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
BCL-2	activates	gene	0.60
NRF2	degrades	gene	0.60
STROKE	inhibits	gene	0.60
KEAP1	degrades	gene	0.60
HO-1	degrades	gene	0.60
NLRP3	degrades	gene	0.60
NQO1	expressed_in	gene	0.60
IL-1	expressed_in	gene	0.60
IL-6	expressed_in	gene	0.60
HMGB1	therapeutic_target	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
AUTOPHAGY	regulates	gene	0.60
NRF2	activates	gene	0.60
GPX4	activates	gene	0.60
ATG5	activates	gene	0.60
LC3	activates	gene	0.60
XCT	activates	gene	0.60
CASPASE8	associated_with	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Caspase-2/3-mediated D421 truncation generates disease-speci	0.455	neurodegeneration	Which specific post-translational modifi
NLRP3 Inflammasome Suppression via Selective Caspase-1 Inhib	0.105	neurodegeneration	Neuroinflammation Biomarker Panel for Ea
Caspase-3 Cleavage of Tau Creates PS-Targeting Specificity	0.000	-	Does tau aggregation specifically cause

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CASPASE in their description or question text

No additional research found