concept

CASPASE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASPASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

822Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	CASPASE

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CASPASE["CASPASE"]
    style CASPASE fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    CASPASE -->|"activates"| PANoptosis["PANoptosis"]
    CASPASE -->|"cleaves"| GSDME([GSDME])
    CASPASE -->|"activates"| neurodegeneration["neurodegeneration"]
    CASPASE -->|"activates"| IL1B([IL1B])
    CASPASE -->|"regulates"| Fibrosis["Fibrosis"]
    CASPASE -->|"interacts"| Cancer["Cancer"]
    CASPASE -->|"interacts"| Als["Als"]
    CASPASE -.->|"inhibits"| Aging["Aging"]
    RIPK1([RIPK1]) -->|"interacts"| CASPASE
    PPARG([PPARG]) -->|"interacts"| CASPASE
    WNT([WNT]) -->|"regulates"| CASPASE
    TFEB([TFEB]) -->|"interacts"| CASPASE
    CFTR([CFTR]) -->|"regulates"| CASPASE
    RICTOR([RICTOR]) -->|"interacts"| CASPASE
    ROS([ROS]) -->|"regulates"| CASPASE
    GRB2([GRB2]) -->|"interacts"| CASPASE
    HSP70([HSP70]) -->|"interacts"| CASPASE
    STAT3([STAT3]) -->|"interacts"| CASPASE

Outgoing (214)

Target	Relation	Type	Str
PANoptosis	activates	process	0.92
neurodegeneration	activates	process	0.70
IL1B	activates	protein	0.60
Fibrosis	regulates	disease	0.60
Cancer	interacts_with	disease	0.60
Als	interacts_with	disease	0.60
Aging	inhibits	disease	0.60
Lymphoma	associated_with	disease	0.60
Cancer	inhibits	disease	0.60
Als	inhibits	disease	0.60
Neurodegeneration	activates	disease	0.60
Ischemia	activates	disease	0.60
Neuroinflammation	activates	disease	0.60
Neuropathy	activates	disease	0.60
Pyroptosis	inhibits	disease	0.60
Ferroptosis	inhibits	disease	0.60
Necroptosis	inhibits	disease	0.60
Fibrosis	inhibits	disease	0.60
Cancer	expressed_in	disease	0.60
Ischemia	inhibits	disease	0.60
Neurodegeneration	inhibits	disease	0.60
Parkinson	inhibits	disease	0.60
Pyroptosis	activates	disease	0.60
Cancer	activates	disease	0.60
Pyroptosis	degrades	disease	0.60
Als	degrades	disease	0.60
Parkinson	activates	disease	0.60
Als	activates	disease	0.60
Retinopathy	associated_with	disease	0.60
Cardiomyopathy	associated_with	disease	0.60
Huntington	expressed_in	disease	0.60
Neurodegeneration	associated_with	disease	0.60
Alzheimer	expressed_in	disease	0.60
Necroptosis	activates	disease	0.60
Ferroptosis	activates	disease	0.60
Aging	activates	disease	0.60
Dementia	causes	disease	0.60
Alzheimer	contributes_to	disease	0.60
Neurodegeneration	causes	disease	0.60
Als	causes	disease	0.60
Neuroinflammation	causes	disease	0.60
Dementia	activates	disease	0.60
Frontotemporal Dementia	activates	disease	0.60
Amyotrophic Lateral Sclerosis	activates	disease	0.60
Alzheimer	causes	disease	0.60
Stroke	inhibits	disease	0.60
Depression	activates	disease	0.60
Neuroinflammation	inhibits	disease	0.60
Hypertension	inhibits	disease	0.60
Cancer	therapeutic_target	disease	0.60

Incoming (608)

Source	Relation	Type	Str
RIPK1	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
WNT	regulates	gene	0.60
TFEB	interacts_with	gene	0.60
CFTR	regulates	gene	0.60
RICTOR	interacts_with	gene	0.60
ROS	regulates	gene	0.60
GRB2	interacts_with	gene	0.60
HSP70	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
IFN	interacts_with	gene	0.60
AMPK	regulates	gene	0.60
DDIT3	interacts_with	gene	0.60
MLST8	interacts_with	gene	0.60
VIM	regulates	gene	0.60
WT1	regulates	gene	0.60
LAMP1	regulates	gene	0.60
OCLN	regulates	gene	0.60
ATG14	associated_with	gene	0.60
VIMENTIN	regulates	gene	0.60
HDAC6	regulates	gene	0.60
TUBULIN	regulates	gene	0.60
MAP3K5	regulates	gene	0.60
TJP1	regulates	gene	0.60
GJA1	associated_with	gene	0.60
ACTB	associated_with	gene	0.60
H2AX	associated_with	gene	0.60
RAC1	regulates	gene	0.60
BECN1	associated_with	gene	0.60
CASPASE8	associated_with	gene	0.60
EHMT2	associated_with	gene	0.60
BAX	associated_with	gene	0.60
CASPASE3	associated_with	gene	0.60
APOPTOSIS	inhibits	gene	0.60
FOXO1	associated_with	gene	0.60
JUN	inhibits	gene	0.60
BCL-2	associated_with	gene	0.60
NLRP3	activates	gene	0.60
MICROGLIA	activates	gene	0.60
C1Q	activates	gene	0.60
GLAUCOMA	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
IL-1	activates	gene	0.60
CPT1A	inhibits	gene	0.60
ALOX15	inhibits	gene	0.60
MLKL	inhibits	gene	0.60
HMGCR	inhibits	gene	0.60
GSDMD	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CASPASE

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Corticobasal Syndrome (CBS)

Novel Therapy Index

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

nimodipine-als

neuroinflammation

NTF4 Protein

Growth Factor Therapies

Neurotrophin Signaling Pathways in Neurodegeneration

omega-3-fatty-acids-neurodegeneration

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

VEGF/Angiogenesis Pathway in Neurodegeneration

Lithium for PSP/CBS — Phase 2 Trial

nlrc5-protein

psp-tauopathy

Infectious Triggers in Alzheimer's Disease

Mitochondrial Dysfunction in Neurodegeneration