concept

CASPASE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASPASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

809Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CASPASE

Pathway Diagram

graph TD
    CASPASE["CASPASE"]
    style CASPASE fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    CASPASE -->|"activates"| PANoptosis["PANoptosis"]
    CASPASE -->|"cleaves"| GSDME([GSDME])
    CASPASE -->|"activates"| neurodegeneration["neurodegeneration"]
    CASPASE -->|"activates"| IL1B([IL1B])
    CASPASE -->|"regulates"| Fibrosis["Fibrosis"]
    CASPASE -->|"interacts"| Cancer["Cancer"]
    CASPASE -->|"interacts"| Als["Als"]
    CASPASE -.->|"inhibits"| Aging["Aging"]
    RIPK1([RIPK1]) -->|"interacts"| CASPASE
    PPARG([PPARG]) -->|"interacts"| CASPASE
    WNT([WNT]) -->|"regulates"| CASPASE
    TFEB([TFEB]) -->|"interacts"| CASPASE
    CFTR([CFTR]) -->|"regulates"| CASPASE
    RICTOR([RICTOR]) -->|"interacts"| CASPASE
    ROS([ROS]) -->|"regulates"| CASPASE
    GRB2([GRB2]) -->|"interacts"| CASPASE
    HSP70([HSP70]) -->|"interacts"| CASPASE
    STAT3([STAT3]) -->|"interacts"| CASPASE

Outgoing (207)

Target	Relation	Type	Str
PANoptosis	activates	process	0.92
neurodegeneration	activates	process	0.70
Lymphoma	phosphorylates	disease	0.60
Necroptosis	protects_against	disease	0.60
Parkinson	protects_against	disease	0.60
Als	protects_against	disease	0.60
Schizophrenia	expressed_in	disease	0.60
Anxiety	expressed_in	disease	0.60
Depression	interacts_with	disease	0.60
Cancer	expressed_in	disease	0.60
Stroke	inhibits	disease	0.60
Parkinson	activates	disease	0.60
Dementia	contributes_to	disease	0.60
Glioblastoma	activates	disease	0.60
Als	activates	disease	0.60
Alzheimer	inhibits	disease	0.60
Depression	expressed_in	disease	0.60
Stroke	regulates	disease	0.60
Diabetes	regulates	disease	0.60
Parkinson	therapeutic_target	disease	0.60
Als	therapeutic_target	disease	0.60
Neuroinflammation	therapeutic_target	disease	0.60
Als	expressed_in	disease	0.60
Neuroinflammation	expressed_in	disease	0.60
Traumatic Brain Injury	activates	disease	0.60
Neurodegeneration	expressed_in	disease	0.60
Atherosclerosis	expressed_in	disease	0.60
Lymphoma	activates	disease	0.60
Vascular Dementia	therapeutic_target	disease	0.60
Obesity	regulates	disease	0.60
Pyroptosis	inhibits	disease	0.60
Ferroptosis	inhibits	disease	0.60
Necroptosis	inhibits	disease	0.60
Fibrosis	inhibits	disease	0.60
Pyroptosis	degrades	disease	0.60
Als	degrades	disease	0.60
Depression	activates	disease	0.60
Neuroinflammation	inhibits	disease	0.60
Dementia	therapeutic_target	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Stroke	therapeutic_target	disease	0.60
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.60
IL1B	activates	protein	0.60
Neurodegeneration	inhibits	disease	0.60
Parkinson	inhibits	disease	0.60
Neuroinflammation	causes	disease	0.60
Dementia	activates	disease	0.60
Frontotemporal Dementia	activates	disease	0.60
Amyotrophic Lateral Sclerosis	activates	disease	0.60
Alzheimer	causes	disease	0.60

Incoming (602)

Source	Relation	Type	Str
MICROGLIA	activates	gene	0.60
C1Q	activates	gene	0.60
GLAUCOMA	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
IL-1	activates	gene	0.60
STING	activates	gene	0.60
CD68	expressed_in	gene	0.60
RNA	activates	gene	0.60
ANXA1	expressed_in	gene	0.60
CGAS-STING	activates	gene	0.60
KLK7	activates	gene	0.60
MYELIN	activates	gene	0.60
SYN2A	activates	gene	0.60
ELAVL3	activates	gene	0.60
BPMC	activates	gene	0.60
GAP43	activates	gene	0.60
ACHE	activates	gene	0.60
GFAP	activates	gene	0.60
MBP	activates	gene	0.60
AXON	activates	gene	0.60
MANF	activates	gene	0.60
AGING	inhibits	gene	0.60
P38	contributes_to	gene	0.60
DEMENTIA	causes	gene	0.60
TAU	causes	gene	0.60
ASTROCYTE	contributes_to	gene	0.60
MAPK	contributes_to	gene	0.60
AMYLOID	causes	gene	0.60
IL-1	causes	gene	0.60
PHAGOCYTOSIS	causes	gene	0.60
DEMENTIA	activates	gene	0.60
TDP-43	activates	gene	0.60
ALS	activates	gene	0.60
GASDERMIN	activates	gene	0.60
SOD1	activates	gene	0.60
FAS	activates	gene	0.60
APOPTOSIS	regulates	gene	0.60
BID	activates	gene	0.60
ALZHEIMER	causes	gene	0.60
AUTOPHAGY	causes	gene	0.60
BCL-2	regulates	gene	0.60
JNK	causes	gene	0.60
P38	phosphorylates	gene	0.60
NAD	inhibits	gene	0.60
GLAUCOMA	phosphorylates	gene	0.60
GSH	inhibits	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
ASC	inhibits	gene	0.60
NLRP3	activates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Caspase-2/3-mediated D421 truncation generates disease-speci	0.455	neurodegeneration	Which specific post-translational modifi
NLRP3 Inflammasome Suppression via Selective Caspase-1 Inhib	0.105	neurodegeneration	Neuroinflammation Biomarker Panel for Ea
Caspase-3 Cleavage of Tau Creates PS-Targeting Specificity	0.000	-	Does tau aggregation specifically cause

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CASPASE in their description or question text

No additional research found