concept

CASPASE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASPASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

809Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CASPASE

Pathway Diagram

graph TD
    CASPASE["CASPASE"]
    style CASPASE fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    CASPASE -->|"activates"| PANoptosis["PANoptosis"]
    CASPASE -->|"cleaves"| GSDME([GSDME])
    CASPASE -->|"activates"| neurodegeneration["neurodegeneration"]
    CASPASE -->|"activates"| IL1B([IL1B])
    CASPASE -->|"regulates"| Fibrosis["Fibrosis"]
    CASPASE -->|"interacts"| Cancer["Cancer"]
    CASPASE -->|"interacts"| Als["Als"]
    CASPASE -.->|"inhibits"| Aging["Aging"]
    RIPK1([RIPK1]) -->|"interacts"| CASPASE
    PPARG([PPARG]) -->|"interacts"| CASPASE
    WNT([WNT]) -->|"regulates"| CASPASE
    TFEB([TFEB]) -->|"interacts"| CASPASE
    CFTR([CFTR]) -->|"regulates"| CASPASE
    RICTOR([RICTOR]) -->|"interacts"| CASPASE
    ROS([ROS]) -->|"regulates"| CASPASE
    GRB2([GRB2]) -->|"interacts"| CASPASE
    HSP70([HSP70]) -->|"interacts"| CASPASE
    STAT3([STAT3]) -->|"interacts"| CASPASE

Outgoing (207)

Target	Relation	Type	Str
PANoptosis	activates	process	0.92
neurodegeneration	activates	process	0.70
Lymphoma	phosphorylates	disease	0.60
Neurodegeneration	causes	disease	0.60
Als	causes	disease	0.60
Neuroinflammation	causes	disease	0.60
Pyroptosis	inhibits	disease	0.60
Dementia	activates	disease	0.60
Multiple Sclerosis	activates	disease	0.60
Traumatic Brain Injury	inhibits	disease	0.60
Glioblastoma	activates	disease	0.60
Frontotemporal Dementia	activates	disease	0.60
Alzheimer	inhibits	disease	0.60
Amyotrophic Lateral Sclerosis	activates	disease	0.60
Stroke	regulates	disease	0.60
Ferroptosis	inhibits	disease	0.60
Atherosclerosis	expressed_in	disease	0.60
Alzheimer	causes	disease	0.60
Epilepsy	therapeutic_target	disease	0.60
Pyroptosis	biomarker_for	disease	0.60
Huntington	activates	disease	0.60
Ferroptosis	biomarker_for	disease	0.60
Neurodegeneration	protects_against	disease	0.60
Pyroptosis	causes	disease	0.60
Hypertension	inhibits	disease	0.60
Necroptosis	inhibits	disease	0.60
Necroptosis	associated_with	disease	0.60
Als	regulates	disease	0.60
Fibrosis	inhibits	disease	0.60
Als	interacts_with	disease	0.60
Pyroptosis	therapeutic_target	disease	0.60
Necroptosis	therapeutic_target	disease	0.60
Pyroptosis	degrades	disease	0.60
Pyroptosis	associated_with	disease	0.60
Cancer	associated_with	disease	0.60
Alzheimer	degrades	disease	0.60
Neurodegeneration	degrades	disease	0.60
Neuroinflammation	degrades	disease	0.60
Als	degrades	disease	0.60
Alzheimer	activates	disease	0.60
Dementia	causes	disease	0.60
Cancer	interacts_with	disease	0.60
Depression	interacts_with	disease	0.60
Fibrosis	regulates	disease	0.60
Ischemia	activates	disease	0.60
Neuroinflammation	activates	disease	0.60
Neuropathy	activates	disease	0.60
Depression	regulates	disease	0.60
Neurodegeneration	regulates	disease	0.60
Multiple Sclerosis	regulates	disease	0.60

Incoming (602)

Source	Relation	Type	Str
WT1	regulates	gene	0.60
LAMP1	regulates	gene	0.60
OCLN	regulates	gene	0.60
ATG14	associated_with	gene	0.60
VIMENTIN	regulates	gene	0.60
HDAC6	regulates	gene	0.60
TUBULIN	regulates	gene	0.60
MAP3K5	regulates	gene	0.60
TJP1	regulates	gene	0.60
GJA1	associated_with	gene	0.60
ACTB	associated_with	gene	0.60
H2AX	associated_with	gene	0.60
RAC1	regulates	gene	0.60
BECN1	associated_with	gene	0.60
STING	activates	gene	0.60
CD68	expressed_in	gene	0.60
RNA	activates	gene	0.60
ANXA1	expressed_in	gene	0.60
CGAS-STING	activates	gene	0.60
NEURON	activates	gene	0.60
GSDMD	activates	gene	0.60
IL-18	activates	gene	0.60
POLE	activates	gene	0.60
PARKINSON	activates	gene	0.60
ATP	activates	gene	0.60
TREM2	activates	gene	0.60
IBA1	activates	gene	0.60
MYELIN	activates	gene	0.60
SYN2A	activates	gene	0.60
ELAVL3	activates	gene	0.60
BPMC	activates	gene	0.60
GAP43	activates	gene	0.60
ACHE	activates	gene	0.60
GFAP	activates	gene	0.60
MBP	activates	gene	0.60
AXON	activates	gene	0.60
MANF	activates	gene	0.60
AGING	inhibits	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
ASC	inhibits	gene	0.60
STROKE	therapeutic_target	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
IL-4	therapeutic_target	gene	0.60
ALS	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
IL-1	therapeutic_target	gene	0.60
GDNF	expressed_in	gene	0.60
VIMENTIN	activates	gene	0.60
AMYLOID-BETA	expressed_in	gene	0.60
VIM	regulates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Caspase-2/3-mediated D421 truncation generates disease-speci	0.455	neurodegeneration	Which specific post-translational modifi
NLRP3 Inflammasome Suppression via Selective Caspase-1 Inhib	0.105	neurodegeneration	Neuroinflammation Biomarker Panel for Ea
Caspase-3 Cleavage of Tau Creates PS-Targeting Specificity	0.000	-	Does tau aggregation specifically cause

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CASPASE in their description or question text

No additional research found