spinal-muscular-atrophy

Understanding Entity Pages

This page aggregates everything SciDEX knows about spinal-muscular-atrophy: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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flowchart TD
    N0["spinal muscular atrophy"]
    N1["endoplasmic reticulum"]
    N0 -->|"disrupts"| N1
    N2["mitochondria"]
    N0 -->|"disrupts"| N2
    N3["lysosome"]
    N0 -->|"disrupts"| N3
    N4["neural stem cells"]
    N0 -->|"affects"| N4
    N5["neurons"]
    N0 -->|"affects"| N5
    N6["glutamate"]
    N0 -->|"disrupts"| N6
    N7["unfolded protein response"]
    N0 -->|"involves"| N7
    N8["macrophages"]
    N0 -->|"affects"| N8
    N9["lipid metabolism"]
    N0 -->|"involves"| N9
    N10["ferroptosis"]
    N0 -->|"involves"| N10
    N11["endosome"]
    N0 -->|"disrupts"| N11
    N12["B cells"]
    N0 -->|"affects"| N12
    N13["T cells"]
    N0 -->|"affects"| N13
    N14["cerebellum"]
    N0 -->|"affects"| N14
    N15["astrocytes"]
    N0 -->|"affects"| N15
    N16["TGF-beta signaling"]
    N0 -->|"involves"| N16

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N7 pathway
    class N9 pathway
    class N10 pathway
    class N16 pathway