concept

RB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2559Connections
4Hypotheses
2Analyses
50Outgoing
50Incoming

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💡 Concept Info
NameRB
Linked Hypotheses6 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Novel Therapy Index

idea · 10647 words

Sleep and Circadian Dysfunction in Alzheimer's Disease

mechanism · 8066 words

PD Cure Roadmap

mechanism · 5171 words

ftd-tdp-pathology

mechanism · 4657 words

AI and Machine Learning in Neurodegeneration

mechanism · 4541 words

Pathway Diagram

graph TD
    RB["RB"]
    style RB fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    RB -->|"interacts"| Als["Als"]
    RB -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    RB -->|"activates"| Dementia["Dementia"]
    RB -->|"activates"| Alzheimer["Alzheimer"]
    RB -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    RB -->|"interacts"| Parkinson["Parkinson"]
    MTOR([MTOR]) -.->|"inhibits"| RB
    AMPK([AMPK]) -->|"interacts"| RB
    ABCA1([ABCA1]) -->|"interacts"| RB
    P2RY12([P2RY12]) -.->|"inhibits"| RB
    ABCG1([ABCG1]) -->|"interacts"| RB
    ALS([ALS]) -->|"interacts"| RB
    MAO([MAO]) -.->|"inhibits"| RB
    ULK1([ULK1]) -->|"interacts"| RB
    ATP([ATP]) -->|"interacts"| RB
    ACTB([ACTB]) -->|"interacts"| RB

Outgoing (465)

TargetRelationTypeStr
Addictionassociated_withdisease0.60
Spinal Muscular Atrophyregulatesdisease0.60
Ptsdinhibitsdisease0.60
Addictioninhibitsdisease0.60
Cerebral Amyloid Angiopathytherapeutic_targetdisease0.60

Incoming (2094)

SourceRelationTypeStr
MTORinhibitsgene0.60
ABCA1interacts_withgene0.60
P2RY12inhibitsgene0.60
ABCG1interacts_withgene0.60
ULK1interacts_withgene0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determ 0.612 neuroinflammation How do B cells mechanistically orchestra
Vicious Cycle Hypothesis: Cholinergic Dysfunction Exacerbate 0.610 - Do β-amyloid plaques and neurofibrillary
Aryl Hydrocarbon Receptor (AhR) Activation by Microbiome Met 0.593 neuroinflammation What molecular mechanisms determine whet
Vascular mural cell degeneration precedes and exacerbates pa 0.520 Alzheimer's disease SEA-AD Single-Cell Analysis: Cell-Type V

Mentioning Analyses (2)

Scientific analyses that reference this entity

Why does iron chelation therapy worsen outcomes in H63D HFE variant carriers des

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.586

Does clusterin exacerbate or protect against neuronal death in neurodegeneration

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.548

Related Papers (15)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Pathophysiology of Primary Familial Brain Calcification. [PMID:41212990] Keller A Annual review of physiology 2026 0
Therapeutic effects of the n-butanol extract of Potentilla freyniana Bornm. in h [PMID:40902811] Wang Y, Zhang Z, Cao L, Huang S, Huang X J Ethnopharmacol 2026 0
Based on network pharmacology and experiments to investigate the inhibitory effe [PMID:41308710] Yang X, Xiao JH, Li X, Liu RM, Yuan Q J Ethnopharmacol 2026 0
Novel insights into meningioma brain invasion with spatial transcriptomic profil [PMID:41486296] Maier AD, Laurentiussen CO, Michaelsen S Acta Neuropathol Commun 2026 0
Brain vascular stability relies on PAK2-cilia-PDGF-BB-HSPGs on basolateral side [PMID:41490797] Prabhudesai S, Thirugnanam K, Song X, Ya Life Sci Alliance 2026 0
Plasma platelet-derived growth factor receptor-β decrease correlates with blood- [PMID:41530860] Li J, Li A, Ye C, Zhang L, Jiang M et al Mol Neurodegener 2026 0
FOXF2 regulates pericyte-endothelial signaling required for vascular homeostasis [PMID:41680210] Sun F, Zhao Y, Do J, Cheng P, Li E et al Nat Commun 2026 0
Molecular Characterization of Biphasic Follicular Dendritic Cell Sarcoma. [PMID:41943444] Hassan F, Boyle T, Palma J, Li J, Hussai Appl Immunohistochem Mol Morph 2026 0
Immunological mechanisms and therapeutic approaches in pulmonary fibrosis. [PMID:41951242] Nell LM, Hendriks RW, Wijsenbeek MS, Cor Eur Respir Rev 2026 0
Loss of Pericyte Exacerbates Alzheimer's Disease-Associated Retinal Pathology. [PMID:41814129] Hai-Chao C, Fu-Lin G, Jia-Xin C, Yi-Shu Clinical & experimental ophtha 2026 0
Nicotinic acetylcholine receptor activation induces BACE1 transcription via the [PMID:38110001] Nakano M, Tsuchida T, Mitsuishi Y, Nishi Neurosci Res 2024 0
The influence of inhibiting or stimulating the expression of the α3 subunit of t [PMID:23201341] Qi XL, Zhang XL, Ou-Yang K, Shan KR, Gua Neurochem Int 2013 0
[Influence of inhibited α7 nicotinic acetylcholine receptor gene expression on t [PMID:23324234] Ouyang K, Qi XL, Guan ZZ Zhonghua Bing Li Xue Za Zhi 2012 0
Effects of galantamine on β-amyloid release and beta-site cleaving enzyme 1 expr [PMID:20600777] Li Q, Wu D, Zhang L, Zhang Y Exp Gerontol 2010 0
Mossy fiber long-term potentiation deficits in BACE1 knock-outs can be rescued b [PMID:20943921] Wang H, Song L, Lee A, Laird F, Wong PC J Neurosci 2010 0