protein

CHI3L1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHI3L1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

361Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

2Experiments

1Debates

Summary

CHI3L1 (Chitinase 3-like Protein 1), also known as YKL-40, is a secreted glycoprotein implicated in neuroinflammation and neurodegenerative diseases including Alzheimer's and Parkinson's.

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🔬 Protein Info

Gene Symbol	CHI3L1
Full Name	Chitinase 3-Like 1
Aliases	Chitinase 3-like Protein 1
Chromosome	1q32.1
Protein Type	Hydrolase
Function	CHI3L1 is a member of the glycosyl hydrolase family 18 but lacks enzymatic activity.
Primary Expression	hippocampus, cortex, and basal ganglia - Cell Types: Primarily microglia and astrocytes -
Molecular Weight	40 kDa
Amino Acids	383 aa
Pathways	NF-κB signaling
UniProt ID	P36222
NCBI Gene ID	1116
Ensembl ID	ENSG00000133048
GeneCards	CHI3L1
Human Protein Atlas	CHI3L1
Associated Diseases	Als, Alzheimer, Fibrosis, Inflammation, neurodegeneration, Neuroinflammation
Known Drugs/Compounds	hygromycin B
Interactions	Actin, AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYOTROPHIC LATERAL SCLEROSIS
SciDEX Hypotheses	Integrated Biomarker Panel for Therapeutic Window
KG Connections	360 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CHI3L1 — AlphaFold P36222 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CHI3L1["CHI3L1"]
    CHI3L1 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    CHI3L1 -->|"expressed in"| Inflammation["Inflammation"]
    CHI3L1 -->|"expressed in"| Neuroinflammation["Neuroinflammation"]
    CHI3L1 -->|"contributes to"| Aging["Aging"]
    CHI3L1 -->|"activates"| Autoimmune["Autoimmune"]
    CHI3L1 -.biomarker for.-> Als["Als"]
    CHI3L1 -.biomarker for.-> Alzheimer["Alzheimer"]
    CHI3L1 -->|"regulates"| Glioblastoma["Glioblastoma"]
    CHI3L1 -->|"inhibits"| Tumor["Tumor"]
    STAT3["STAT3"] -->|"regulates"| CHI3L1
    IL9["IL9"] -.biomarker for.-> CHI3L1
    IL4["IL4"] -.biomarker for.-> CHI3L1
    FGF2["FGF2"] -.biomarker for.-> CHI3L1
    GFAP["GFAP"] -.biomarker for.-> CHI3L1
    MDH1["MDH1"] -.biomarker for.-> CHI3L1
    SQSTM1["SQSTM1"] -.biomarker for.-> CHI3L1
    BDNF["BDNF"] -.biomarker for.-> CHI3L1
    APOE["APOE"] -.biomarker for.-> CHI3L1
    NEFL["NEFL"] -.biomarker for.-> CHI3L1

Outgoing (267)

Target	Relation	Type	Str
Hippocampal Neurogenesis	inhibits	process	0.95
Neuroinflammation	involved_in	process	0.95
Astrocytes	expressed_in	cell_type	0.95
YKL-40	encodes	protein	0.95
STAT3	binds_to	protein	0.95
proneural-mesenchymal transition	promotes	process	0.90
Neuromyelitis Optica	biomarker_for	disease	0.90
Glial Activation	regulates	process	0.90
CRTH2	binds	receptor	0.90
Neuromyelitis Optica	biomarker_for	disease	0.90
ASTROCYTE	secreted_by	cell_type	0.90
Alzheimer'S Disease	involved_in	disease	0.90
Neuronal Differentiation	inhibits	process	0.90
Neural Stem Cell Proliferation	inhibits	process	0.90
Microglia	modulates	cell_type	0.85
Neuroinflammation	biomarker_for	process	0.85
Cognitive Impairment	correlates_with	phenotype	0.85
AD Progression	risk_factor_for	phenotype	0.85
Amyloid Plaque Burden	modulates	phenotype	0.85
Astrocyte Circadian Clock	associated_with	process	0.85
macrophage phenotype	modulates	phenotype	0.84
Microglial Activation	modulates	process	0.80
Astrocyte Activation	regulates	process	0.80
neural stem cells	inhibits	cell_type	0.80
Als	activates	disease	0.75
Neurodegeneration	activates	disease	0.75
Phagocytosis	suppresses	process	0.75
Autoimmune	activates	disease	0.75
Glial Phagocytosis	inhibits	process	0.75
hippocampus	expressed_in	brain_region	0.70
astrocytes	expressed_in	cell_type	0.70
stem cells	expressed_in	cell_type	0.70
neurons	expressed_in	cell_type	0.70
ASTROCYTES	activates	gene	0.70
Neuroinflammation	expressed_in	disease	0.65
Aging	contributes_to	disease	0.65
Glioblastoma	regulates	disease	0.65
Tumor	inhibits	disease	0.65
Ms	activates	disease	0.65
Diabetes	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Inflammation	expressed_in	disease	0.65
Diabetes	interacts_with	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Aging	activates	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65

Incoming (94)

Source	Relation	Type	Str
Astrocytes	expressed_in	cell_type	0.95
AQP4	regulates	protein	0.90
AQP4 Autoantibodies	upregulates	compound	0.90
Astrocyte	product_of	cell_type	0.90
hygromycin B	inhibits	drug	0.85
STAT3	regulates	protein	0.80
STAT3	interacts_with	gene	0.80
IL-10	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
GLIOBLASTOMA	regulates	gene	0.60
ARG1	activates	gene	0.60
AIF1	biomarker_for	gene	0.60
C1QA	biomarker_for	gene	0.60
C1QB	biomarker_for	gene	0.60
C1QC	biomarker_for	gene	0.60
C1R	biomarker_for	gene	0.60
C1S	biomarker_for	gene	0.60
C3	biomarker_for	gene	0.60
AMYLOID	inhibits	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
APP/PS1	inhibits	gene	0.60
NPTX1	associated_with	gene	0.60
CHIT1	associated_with	gene	0.60
MDH1	biomarker_for	gene	0.60
PDGFRB	associated_with	gene	0.60
SQSTM1	biomarker_for	gene	0.60
BDNF	biomarker_for	gene	0.60
APOE	biomarker_for	gene	0.60
NEFL	biomarker_for	gene	0.60
SPP1	regulates	gene	0.60
STAT3	activates	gene	0.60
GBM	activates	gene	0.60
TAU	associated_with	gene	0.60
RAGE	inhibits	gene	0.60
OVERVIEW	activates	gene	0.60
CXCL8	associated_with	gene	0.60
APOE Ε4	biomarker_for	gene	0.60
VEGFA	associated_with	gene	0.60
IL4	biomarker_for	gene	0.60
FGF2	biomarker_for	gene	0.60
GFAP	biomarker_for	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
IL9	biomarker_for	gene	0.60
ASTROCYTES	activates	gene	0.60
NEURODEGENERATION	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
APOPTOSIS	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
PARKINSON	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Integrated Biomarker Panel for Therapeutic Window Identifica	0.784	neurodegeneration	What are the precise temporal dynamics o

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the precise temporal dynamics of astrocyte ketone production decline du

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.808

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Chi3l1 deletion effects on baseline glial activation in mice	validation	baseline neuroinflammation	0.900	0.00	Chi3l1 knockout mice	proposed	N/A
CHI3L1 variant association with AD progression in human patients	exploratory	Alzheimer's disease	0.850	0.00	human patients	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate identified a critical therapeutic window when astrocytic ketone produ

closed · Rounds: 4 · Score: 0.85 · 2026-04-15