concept

INTERFERON

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INTERFERON: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

556Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

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💡 Concept Info

Name	INTERFERON
Key Genes/Proteins	ABCD3, ACTIN, ALZHEIMER DISEASE, AMBRA1, AMPK, ATG
Related Diseases	ALS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Interferon Signaling in Neurodegeneration

mechanism · 2944 words

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Pathway Diagram

graph TD
    INTERFERON["INTERFERON"]
    style INTERFERON fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    INTERFERON -->|"interacts"| Dementia["Dementia"]
    INTERFERON -->|"interacts"| Alzheimer["Alzheimer"]
    INTERFERON -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    INTERFERON -->|"interacts"| Parkinson["Parkinson"]
    INTERFERON -->|"interacts"| Als["Als"]
    INTERFERON -->|"activates"| Aging["Aging"]
    INTERFERON -->|"interacts"| Fibrosis["Fibrosis"]
    INTERFERON -->|"interacts"| Cancer["Cancer"]
    INTERFERON -->|"activates"| Ferroptosis["Ferroptosis"]
    NBR1([NBR1]) -.->|"inhibits"| INTERFERON
    p62([p62]) -->|"activates"| INTERFERON
    STING["STING"] -->|"upregulates"| INTERFERON
    HNRNPA1([HNRNPA1]) -->|"upregulates"| INTERFERON
    STING1([STING1]) -->|"activates"| INTERFERON
    DISC1([DISC1]) -->|"interacts"| INTERFERON
    GBA([GBA]) -->|"interacts"| INTERFERON
    TAX1BP1([TAX1BP1]) -->|"interacts"| INTERFERON
    ROS([ROS]) -->|"interacts"| INTERFERON
    ALS([ALS]) -->|"interacts"| INTERFERON

Outgoing (146)

Target	Relation	Type	Str
ZBP1	upregulates	protein	0.85
Amyotrophic Lateral Sclerosis	activates	disease	0.60
Als	therapeutic_target	disease	0.60
Alzheimer	associated_with	disease	0.60
Ferroptosis	inhibits	disease	0.60
Neurodegeneration	associated_with	disease	0.60
Multiple Sclerosis	associated_with	disease	0.60
Neuroinflammation	causes	disease	0.60
Alzheimer	causes	disease	0.60
Aging	expressed_in	disease	0.60
Als	expressed_in	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Parkinson	inhibits	disease	0.60
Epilepsy	activates	disease	0.60
Neurodegeneration	therapeutic_target	disease	0.60
Multiple Sclerosis	therapeutic_target	disease	0.60
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.60
Parkinson	therapeutic_target	disease	0.60
Huntington	therapeutic_target	disease	0.60
Neuroinflammation	therapeutic_target	disease	0.60
Encephalitis	associated_with	disease	0.60
Parkinson	activates	disease	0.60
Neuroinflammation	activates	disease	0.60
Neurodegeneration	degrades	disease	0.60
Ferroptosis	degrades	disease	0.60
Multiple Sclerosis	degrades	disease	0.60
Neuroinflammation	associated_with	disease	0.60
Stroke	interacts_with	disease	0.60
Frontotemporal Dementia	activates	disease	0.60
Cancer	associated_with	disease	0.60
Alzheimer	inhibits	disease	0.60
Parkinson	regulates	disease	0.60
Neuroinflammation	regulates	disease	0.60
Pyroptosis	regulates	disease	0.60
Als	inhibits	disease	0.60
Lymphoma	activates	disease	0.60
Atherosclerosis	activates	disease	0.60
Ischemia	activates	disease	0.60
Dementia	activates	disease	0.60
Alzheimer	activates	disease	0.60
Ferroptosis	activates	disease	0.60
Encephalitis	therapeutic_target	disease	0.60
Cancer	regulates	disease	0.60
Tauopathy	activates	disease	0.60
Als	activates	disease	0.60
Cancer	interacts_with	disease	0.60
Fibrosis	interacts_with	disease	0.60
Dementia	interacts_with	disease	0.60
Alzheimer	interacts_with	disease	0.60
Frontotemporal Dementia	interacts_with	disease	0.60

Incoming (410)

Source	Relation	Type	Str
NBR1	inhibits	protein	0.90
p62	activates	protein	0.90
STING	upregulates	entity	0.90
HNRNPA1	upregulates	protein	0.85
STING1	activates	protein	0.70
ANGPT1	activates	gene	0.60
PDGFRB	activates	gene	0.60
CD8	associated_with	gene	0.60
PD-1	activates	gene	0.60
JUN	therapeutic_target	gene	0.60
IRF4	activates	gene	0.60
MYC	therapeutic_target	gene	0.60
MHC-I	inhibits	gene	0.60
TRAIL	inhibits	gene	0.60
IFNG	activates	gene	0.60
STAT1	activates	gene	0.60
TLR4	activates	gene	0.60
STAT3	activates	gene	0.60
EGFR	activates	gene	0.60
CYTOKINES	activates	gene	0.60
IRF1	inhibits	gene	0.60
UBIQUITIN	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
ATG5	inhibits	gene	0.60
MERTK	activates	gene	0.60
AKT	activates	gene	0.60
IL-10	activates	gene	0.60
IRF8	activates	gene	0.60
MAF	activates	gene	0.60
MTOR	activates	gene	0.60
MAPK	activates	gene	0.60
LDL	activates	gene	0.60
RNA	causes	gene	0.60
OVERVIEW	activates	gene	0.60
STROKE	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
IFI27L2A	activates	gene	0.60
RNA	regulates	gene	0.60
ROS	activates	gene	0.60
AGING	activates	gene	0.60
AMPK	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
RNA	protects_against	gene	0.60
APOPTOSIS	protects_against	gene	0.60
FGF21	activates	gene	0.60
APOPTOSIS	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
AIM2	activates	gene	0.60
MLKL	activates	gene	0.60
RIPK3	activates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
miR-155/Interferon-gamma Feedback Loop as a Reversible Molec	0.843	neurodegeneration	How do different microglial subtypes (DA
Chronic cGAS/STING Hyperactivation Drives Progressive Neurod	0.661	neuroinflammation	How does chronic cGAS/STING activation d

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Anti-miR-155 LNA Oligonucleotide Shifts Microglia to Homeostatic State	in_vivo	neurodegeneration	0.774	0.65	C57BL/6J LPS model (chronic i.	proposed	$58,000

Related Papers (7)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Changes in Circulating Levels of miR-30b During Minipuberty and Puberty in Girls [PMID:40899010]	Albrechtsen HM, Saritas G, Winge SB, Mai	J Clin Endocrinol Metab	2026
Epigenetics in chronic rhinosinusitis. [PMID:41442742]	Kumar N, Brar T, Lal D	Curr Opin Otolaryngol Head Nec	2026
Extracellular vesicles in type 2 diabetes exhibit elevated miR-155 cargo and Ann [PMID:41786286]	Jackson G, Islam H, de Souza Teixeira AA	Life Sci	2026
Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207]	Mishra R, Gupta JK	Curr Alzheimer Res	2026
Di-2-ethylhexylphthalate-induced miR155-5P promotes placental ferroptosis. [PMID:41937013]	Gu X, Sun F, Li Y, Yang S, Li Y	Int J Biol Macromol	2026
Extracellular Vesicles in Obesity: From Pathophysiological Mediators to Therapeu [PMID:41977323]	Pavlović N, Todorović P, Maglica M, Kopi	Int J Mol Sci	2026
Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207]	Mishra R, Gupta JK	Current Alzheimer research	2026

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning INTERFERON in their description or question text

No additional research found