Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about INTERFERON: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
| Name | INTERFERON |
| Summary | Therapeutic strategy targeting chronic type I interferon signaling via JAK-STAT inhibition, STING blockade, and IFN receptor antagonism |
| Key Genes/Proteins | TAX1BP1, ABCD3, ALZHEIMER DISEASE, MYOT, AMBRA1, AMPK |
| Related Diseases | ALS, LATE |
Knowledge base pages for this entity
graph TD
INTERFERON["INTERFERON"]
style INTERFERON fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
INTERFERON -->|"interacts"| Dementia["Dementia"]
INTERFERON -->|"interacts"| Alzheimer["Alzheimer"]
INTERFERON -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
INTERFERON -->|"interacts"| Parkinson["Parkinson"]
INTERFERON -->|"interacts"| Als["Als"]
INTERFERON -->|"activates"| Aging["Aging"]
INTERFERON -->|"interacts"| Fibrosis["Fibrosis"]
INTERFERON -->|"interacts"| Cancer["Cancer"]
INTERFERON -->|"activates"| Ferroptosis["Ferroptosis"]
NBR1([NBR1]) -.->|"inhibits"| INTERFERON
p62([p62]) -->|"activates"| INTERFERON
STING["STING"] -->|"upregulates"| INTERFERON
HNRNPA1([HNRNPA1]) -->|"upregulates"| INTERFERON
STING1([STING1]) -->|"activates"| INTERFERON
DISC1([DISC1]) -->|"interacts"| INTERFERON
GBA([GBA]) -->|"interacts"| INTERFERON
TAX1BP1([TAX1BP1]) -->|"interacts"| INTERFERON
ROS([ROS]) -->|"interacts"| INTERFERON
ALS([ALS]) -->|"interacts"| INTERFERON| Target | Relation | Type | Str |
|---|---|---|---|
| RAPAMYCIN | associated_with | drug | 0.45 |
| LOVASTATIN | associated_with | drug | 0.45 |
| TAX1BP1 | co_discussed | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| STING | upregulates | entity | 0.90 |
| AUTOPHAGY | co_discussed | process | 0.40 |
| ABCD3 | co_discussed | gene | 0.40 |
| ALZHEIMER DISEASE | co_discussed | gene | 0.40 |
| ALS | co_discussed | disease | 0.40 |
| MYOT | co_discussed | gene | 0.40 |
| LATE | co_discussed | disease | 0.40 |
| AMBRA1 | co_discussed | protein | 0.40 |
| AMPK | co_discussed | protein | 0.40 |
| UBIQUITIN | co_discussed | protein | 0.40 |
| ATG | co_discussed | gene | 0.40 |
| RELA | co_discussed | gene | 0.40 |
| ATM | co_discussed | protein | 0.40 |
| BCL2 | co_discussed | gene | 0.40 |
| APOPTOSIS | co_discussed | process | 0.40 |
| BCL2L11 | co_discussed | gene | 0.40 |
| BIM | co_discussed | protein | 0.40 |
| BCL2L13 | co_discussed | gene | 0.40 |
| BECN1 | co_discussed | gene | 0.40 |
| BNIP3 | co_discussed | gene | 0.40 |
| ACTIN | co_discussed | protein | 0.40 |
| BNIP3L | co_discussed | protein | 0.40 |
| CALCOCO2 | co_discussed | gene | 0.40 |
| NDP52 | co_discussed | gene | 0.40 |
| CANX | co_discussed | gene | 0.40 |
| CAT | co_discussed | gene | 0.40 |
| CATALASE | co_discussed | protein | 0.40 |
| CELL CYCLE | co_discussed | pathway | 0.40 |
| COPD | co_discussed | disease | 0.40 |
| CTSD | co_discussed | gene | 0.40 |
| HEPSIN | co_discussed | protein | 0.40 |
| DDIT3 | co_discussed | gene | 0.40 |
| CHOP | co_discussed | gene | 0.40 |
| DNA | co_discussed | protein | 0.40 |
| DISC1 | co_discussed | gene | 0.40 |
| DNM1L | co_discussed | gene | 0.40 |
| DRP1 | co_discussed | protein | 0.40 |
| EIF2AK3 | co_discussed | gene | 0.40 |
| PERK | co_discussed | protein | 0.40 |
| EIF2S1 | co_discussed | gene | 0.40 |
| EIF2Α | co_discussed | protein | 0.40 |
| EMD | co_discussed | gene | 0.40 |
| EPAS1 | co_discussed | gene | 0.40 |
| ERN1 | co_discussed | gene | 0.40 |
| IRE1 | co_discussed | protein | 0.40 |
| GNAL | co_discussed | gene | 0.40 |
| FTD | co_discussed | disease | 0.40 |
| FRONTOTEMPORAL DEMENTIA | co_discussed | disease | 0.40 |
| FUNDC1 | co_discussed | gene | 0.40 |
| G3BP1 | co_discussed | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||