concept

INTERFERON

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INTERFERON: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

556Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

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💡 Concept Info

Name	INTERFERON
Key Genes/Proteins	ABCD3, ACTIN, ALZHEIMER DISEASE, AMBRA1, AMPK, ATG
Related Diseases	ALS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Interferon Signaling in Neurodegeneration

mechanism · 2944 words

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Pathway Diagram

graph TD
    INTERFERON["INTERFERON"]
    style INTERFERON fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    INTERFERON -->|"interacts"| Dementia["Dementia"]
    INTERFERON -->|"interacts"| Alzheimer["Alzheimer"]
    INTERFERON -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    INTERFERON -->|"interacts"| Parkinson["Parkinson"]
    INTERFERON -->|"interacts"| Als["Als"]
    INTERFERON -->|"activates"| Aging["Aging"]
    INTERFERON -->|"interacts"| Fibrosis["Fibrosis"]
    INTERFERON -->|"interacts"| Cancer["Cancer"]
    INTERFERON -->|"activates"| Ferroptosis["Ferroptosis"]
    NBR1([NBR1]) -.->|"inhibits"| INTERFERON
    p62([p62]) -->|"activates"| INTERFERON
    STING["STING"] -->|"upregulates"| INTERFERON
    HNRNPA1([HNRNPA1]) -->|"upregulates"| INTERFERON
    STING1([STING1]) -->|"activates"| INTERFERON
    DISC1([DISC1]) -->|"interacts"| INTERFERON
    GBA([GBA]) -->|"interacts"| INTERFERON
    TAX1BP1([TAX1BP1]) -->|"interacts"| INTERFERON
    ROS([ROS]) -->|"interacts"| INTERFERON
    ALS([ALS]) -->|"interacts"| INTERFERON

Outgoing (146)

Target	Relation	Type	Str
ZBP1	upregulates	protein	0.85
Alzheimer	interacts_with	disease	0.60
Frontotemporal Dementia	interacts_with	disease	0.60
Parkinson	interacts_with	disease	0.60
Als	interacts_with	disease	0.60
Alzheimer	regulates	disease	0.60
Als	inhibits	disease	0.60
Neurodegeneration	activates	disease	0.60
Multiple Sclerosis	activates	disease	0.60
Cancer	associated_with	disease	0.60
Als	therapeutic_target	disease	0.60
Aging	expressed_in	disease	0.60
Als	expressed_in	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Neurodegeneration	therapeutic_target	disease	0.60
Multiple Sclerosis	therapeutic_target	disease	0.60
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.60
Parkinson	therapeutic_target	disease	0.60
Huntington	therapeutic_target	disease	0.60
Neuroinflammation	therapeutic_target	disease	0.60
Parkinson	activates	disease	0.60
Neuroinflammation	activates	disease	0.60
Neurodegeneration	degrades	disease	0.60
Ferroptosis	degrades	disease	0.60
Multiple Sclerosis	degrades	disease	0.60
Aging	therapeutic_target	disease	0.60
Senescence	therapeutic_target	disease	0.60
Dementia	activates	disease	0.60
Alzheimer	activates	disease	0.60
Neuroinflammation	causes	disease	0.60
Alzheimer	causes	disease	0.60
Spinal Cord Injury	activates	disease	0.60
Parkinson	inhibits	disease	0.60
Depression	activates	disease	0.60
Encephalitis	regulates	disease	0.60
Als	encodes	disease	0.60
Multiple Sclerosis	expressed_in	disease	0.60
Aging	activates	disease	0.60
Amyotrophic Lateral Sclerosis	associated_with	disease	0.60
Als	associated_with	disease	0.60
Cancer	activates	disease	0.60
Neurodegeneration	regulates	disease	0.60
Dementia	interacts_with	disease	0.60
Als	regulates	disease	0.60
Alzheimer	associated_with	disease	0.60
Neurodegeneration	associated_with	disease	0.60
Multiple Sclerosis	associated_with	disease	0.60
Encephalitis	associated_with	disease	0.60
Neuroinflammation	associated_with	disease	0.60
Stroke	interacts_with	disease	0.60

Incoming (410)

Source	Relation	Type	Str
STING	upregulates	entity	0.90
NBR1	inhibits	protein	0.90
p62	activates	protein	0.90
HNRNPA1	upregulates	protein	0.85
STING1	activates	protein	0.70
SLC17A7	therapeutic_target	gene	0.60
ISG15	therapeutic_target	gene	0.60
CDK5R2	therapeutic_target	gene	0.60
SCN2B	therapeutic_target	gene	0.60
NEURON	regulates	gene	0.60
GSK3	regulates	gene	0.60
ERK1	regulates	gene	0.60
PKC	regulates	gene	0.60
PI3K	regulates	gene	0.60
LRRN1	regulates	gene	0.60
EPHA8	regulates	gene	0.60
SMPD1	regulates	gene	0.60
TNFR1	activates	gene	0.60
TNF	activates	gene	0.60
IFN	regulates	gene	0.60
MICROGLIA	expressed_in	gene	0.60
P2RX7	expressed_in	gene	0.60
TAUOPATHY	activates	gene	0.60
HMGCR	inhibits	gene	0.60
PP2A	inhibits	gene	0.60
BACE1	activates	gene	0.60
IRF7	activates	gene	0.60
NLRP3	regulates	gene	0.60
PYROPTOSIS	regulates	gene	0.60
GLAUCOMA	activates	gene	0.60
GRM5	therapeutic_target	gene	0.60
STAT1	therapeutic_target	gene	0.60
FGF13	therapeutic_target	gene	0.60
SCN8A	therapeutic_target	gene	0.60
DISC1	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
IFN	associated_with	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
miR-155/Interferon-gamma Feedback Loop as a Reversible Molec	0.843	neurodegeneration	How do different microglial subtypes (DA
Chronic cGAS/STING Hyperactivation Drives Progressive Neurod	0.661	neuroinflammation	How does chronic cGAS/STING activation d

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Anti-miR-155 LNA Oligonucleotide Shifts Microglia to Homeostatic State	in_vivo	neurodegeneration	0.774	0.65	C57BL/6J LPS model (chronic i.	proposed	$58,000

Related Papers (7)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Changes in Circulating Levels of miR-30b During Minipuberty and Puberty in Girls [PMID:40899010]	Albrechtsen HM, Saritas G, Winge SB, Mai	J Clin Endocrinol Metab	2026
Epigenetics in chronic rhinosinusitis. [PMID:41442742]	Kumar N, Brar T, Lal D	Curr Opin Otolaryngol Head Nec	2026
Extracellular vesicles in type 2 diabetes exhibit elevated miR-155 cargo and Ann [PMID:41786286]	Jackson G, Islam H, de Souza Teixeira AA	Life Sci	2026
Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207]	Mishra R, Gupta JK	Curr Alzheimer Res	2026
Di-2-ethylhexylphthalate-induced miR155-5P promotes placental ferroptosis. [PMID:41937013]	Gu X, Sun F, Li Y, Yang S, Li Y	Int J Biol Macromol	2026
Extracellular Vesicles in Obesity: From Pathophysiological Mediators to Therapeu [PMID:41977323]	Pavlović N, Todorović P, Maglica M, Kopi	Int J Mol Sci	2026
Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207]	Mishra R, Gupta JK	Current Alzheimer research	2026

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning INTERFERON in their description or question text

No additional research found