concept

NUCLEOPHAGY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NUCLEOPHAGY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

231Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

NUCLEOPHAGY is a concept in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with ALS, Aging, Als. Connected to 177 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	NUCLEOPHAGY
Key Genes/Proteins	SIRT1
Related Diseases	Neurodegeneration, Ms, Cardiovascular, Aging, Als

Wiki Pages (10)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    NUCLEOPHAGY["NUCLEOPHAGY"]
    NUCLEOPHAGY -->|"target for"| Ms["Ms"]
    NUCLEOPHAGY -->|"target for"| Cardiovascular["Cardiovascular"]
    NUCLEOPHAGY -->|"activates"| Als["Als"]
    NUCLEOPHAGY -->|"interacts"| Alzheimer["Alzheimer"]
    NUCLEOPHAGY -->|"interacts"| ALS["ALS"]
    NUCLEOPHAGY -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    NUCLEOPHAGY -->|"interacts"| Dementia["Dementia"]
    NUCLEOPHAGY -->|"interacts"| Parkinson["Parkinson"]
    SIRT1["SIRT1"] -->|"activates"| NUCLEOPHAGY
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| NUCLEOPHAGY
    NUCLEAR_INTEGRITY["NUCLEAR INTEGRITY"] -->|"activates"| NUCLEOPHAGY
    BCL2L11["BCL2L11"] -->|"interacts"| NUCLEOPHAGY
    DNA["DNA"] -->|"interacts"| NUCLEOPHAGY
    NIX["NIX"] -->|"interacts"| NUCLEOPHAGY
    HIF1["HIF1"] -->|"interacts"| NUCLEOPHAGY
    RB1["RB1"] -->|"interacts"| NUCLEOPHAGY
    NLRP3["NLRP3"] -->|"interacts"| NUCLEOPHAGY
    PARKINSON["PARKINSON"] -->|"interacts"| NUCLEOPHAGY

Outgoing (130)

Target	Relation	Type	Str
Neurodegeneration	associated_with	disease	0.75
Ms	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Aging	associated_with	disease	0.65
Als	activates	disease	0.65
Cancer	associated_with	disease	0.65
Ms	activates	disease	0.65
Autoimmune	associated_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Cancer	regulates	disease	0.65
Als	regulates	disease	0.65
Als	interacts_with	disease	0.65
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
MITOPHAGY	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
Mitophagy	associated_with	pathway	0.60
Autophagy	activates	pathway	0.60
APOPTOSIS	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
ABCD3	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
JNK	interacts_with	gene	0.60
RIPK3	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
FAM134B	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
PRESENILIN	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
RTN3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
LC3B	interacts_with	gene	0.60
SESN2	interacts_with	gene	0.60
CHOP	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
RIP3	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60

Incoming (101)

Source	Relation	Type	Str
SIRT1	associated_with	gene	0.80
AGING	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
SIRT1	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
NUCLEAR INTEGRITY	activates	gene	0.60
BCL2L11	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
NIX	interacts_with	gene	0.60
HIF1	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
PARL	interacts_with	gene	0.60
EIF2S1	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
PERK	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
PGAM5	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
RHOT1	interacts_with	gene	0.60
RETREG1	interacts_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
STING1	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
MAPK8	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
MITOPHAGY	associated_with	gene	0.60
HIF	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
BIM	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NUCLEOPHAGY

Understanding Entity Pages

Summary

Wiki Pages (10)

FOXO1 Protein

Shared Proteinostasis Failure in Alzheimer's and Parkinson's Disease

Nucleocytoplasmic Transport Defects in Neurodegenerative Diseases

mRNA Therapeutics for Neurodegenerative Diseases

Marinesco Bodies in Neurodegeneration

Nucleolar Stress in Neurodegeneration

GABARAP Protein

Organelle-Specific Autophagy (Selective Autophagy)