concept

FIBROBLAST

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FIBROBLAST: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1039Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	FIBROBLAST
Related Pathways	AUTOPHAGY

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Fibroblast Growth Factor Signaling in Neurodegeneration

mechanism · 1987 words

→

Pathway Diagram

graph TD
    FIBROBLAST["FIBROBLAST"]
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| FIBROBLAST
    MICROTUBULES["MICROTUBULES"] -->|"expressed in"| FIBROBLAST
    MAP6["MAP6"] -->|"expressed in"| FIBROBLAST
    TAU["TAU"] -->|"expressed in"| FIBROBLAST
    ROS["ROS"] -->|"expressed in"| FIBROBLAST
    BCL_2["BCL-2"] -->|"expressed in"| FIBROBLAST
    BAD["BAD"] -->|"expressed in"| FIBROBLAST
    HSPG2["HSPG2"] -->|"expressed in"| FIBROBLAST
    IGF1R["IGF1R"] -->|"expressed in"| FIBROBLAST
    DAG1["DAG1"] -->|"expressed in"| FIBROBLAST

Outgoing (56)

Target	Relation	Type	Str
myofibroblast	involved_in	cell_type	0.85
Myofibroblast	associated_with	cell_type	0.85
GLUT4	activates	concept	0.50
GLUCOSE METABOLISM	activates	concept	0.50
Reactive Oxygen Species	interacts_with	process	0.50
EXTRACELLULAR MATRIX	interacts_with	concept	0.50
CHRONIC INFLAMMATION	interacts_with	concept	0.50
INSULIN	interacts_with	concept	0.50
Proteins	interacts_with	protein	0.50
CELL PROLIFERATION	activates	concept	0.50
Sepsis	associated_with	disease	0.50
Pi3K/Akt	activates	pathway	0.50
Pulmonary Fibrosis	activates	disease	0.50
PI3K/AKT/mTOR	activates	pathway	0.50
disease	activates	disease	0.50
FIBROBLASTS	activates	concept	0.50
MTOR SIGNALING	activates	concept	0.50
Rheumatoid Arthritis	associated_with	disease	0.50
disease	expressed_in	disease	0.50
Spinocerebellar Ataxia	expressed_in	disease	0.50
ALZHEIMER'S	expressed_in	concept	0.50
PARKINSON'S	expressed_in	concept	0.50
FRONTOTEMPORAL	expressed_in	concept	0.50
HUNTINGTON'S	expressed_in	concept	0.50
STAU1	expressed_in	concept	0.50
Tgf-Β Signaling	activates	pathway	0.50
Cerebellum	expressed_in	brain_region	0.50
Cortex	expressed_in	brain_region	0.50
Striatum	expressed_in	brain_region	0.50
Substantia Nigra	expressed_in	brain_region	0.50
Dentate Gyrus	expressed_in	brain_region	0.50
Basal Ganglia	expressed_in	brain_region	0.50
White Matter	expressed_in	brain_region	0.50
Corpus Callosum	expressed_in	brain_region	0.50
ENDOTHELIAL	associated_with	concept	0.50
T CELLS	associated_with	concept	0.50
PERICYTES	associated_with	concept	0.50
ENDOTHELIAL CELLS	associated_with	concept	0.50
FIBROBLASTS	associated_with	concept	0.50
B CELLS	associated_with	concept	0.50
PDGF	activates	concept	0.50
Pancreatic Cancer	inhibits	disease	0.50
Rheumatoid Arthritis	protects_against	disease	0.50
NEURONS	inhibits	concept	0.50
FIBROBLASTS	inhibits	concept	0.50
NEURONS	activates	concept	0.50
NEURONS	associated_with	concept	0.50
Spinal Cord	expressed_in	brain_region	0.50
FIBROBLASTS	interacts_with	concept	0.50
disease	interacts_with	disease	0.50

Incoming (983)

Source	Relation	Type	Str
AGING	regulates	gene	0.60
IGF-1	associated_with	gene	0.60
YTHDF1	regulates	gene	0.60
PIEZO	regulates	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
MTOR	associated_with	gene	0.60
ERK1/2	interacts_with	gene	0.60
FGF1	interacts_with	gene	0.60
AMPK	activates	gene	0.60
BMP2	activates	gene	0.60
SNAP25	activates	gene	0.60
LC3B	activates	gene	0.60
TAX1BP1	interacts_with	gene	0.60
NRF2	associated_with	gene	0.60
USP7	inhibits	gene	0.60
EXOSOMES	associated_with	gene	0.60
ALOX15	inhibits	gene	0.60
DNA	interacts_with	gene	0.60
PDGFRB	activates	gene	0.60
LRP1	activates	gene	0.60
EXOSOMES	activates	gene	0.60
AXL	activates	gene	0.60
POSTN	activates	gene	0.60
BLM	activates	gene	0.60
STX11	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
MLKL	regulates	gene	0.60
RIPK1	interacts_with	gene	0.60
RIPK3	regulates	gene	0.60
TNFR1	regulates	gene	0.60
TAU	regulates	gene	0.60
MICROTUBULES	regulates	gene	0.60
MAP6	regulates	gene	0.60
HNRNPA1	inhibits	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
MIRNAS	inhibits	gene	0.60
RNA	associated_with	gene	0.60
ARF1	activates	gene	0.60
FGF2	interacts_with	gene	0.60
FGF	interacts_with	gene	0.60
STAT3	activates	gene	0.60
PDGF	activates	gene	0.60
BRSK2	activates	gene	0.60
SOD1	activates	gene	0.60
APOPTOSIS	contributes_to	gene	0.60
MAPK	contributes_to	gene	0.60
AUTOPHAGY	regulates	gene	0.60
PIEZO2	regulates	gene	0.60
FGF21	associated_with	gene	0.60
CD8	regulates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
YAP/TAZ Mechanosensing Cooperates with NF-κB to Amplify SPP1	0.492	neurodegeneration	How do perivascular cells specifically r
RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upre	0.442	neurodegeneration	How do perivascular cells specifically r

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FIBROBLAST in their description or question text

No additional research found