gene

HDAC6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HDAC6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1125Connections

6Hypotheses

7Analyses

50Outgoing

50Incoming

0Experiments

8Debates

Summary

Cytoplasmic deacetylase critical for protein quality control, aggresome formation, and autophagy in neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	HDAC6
Full Name	Histone Deacetylase 6
Chromosome	Xp11.23
Protein Type	Protein
Function	is a unique class IIb histone deacetylase that predominantly localizes to the cytoplasm rather than the nucleus.
Primary Expression	Ubiquitous, highest in brain, liver, kidney
Molecular Weight	131 kDa
Amino Acids	1215 aa
Pathways	AUTOPHAGY, Amyloid, Autophagy, Dna Repair, Inflammasome
UniProt ID	Q9UQR8
NCBI Gene ID	10013
Ensembl ID	ENSG00000094631
GeneCards	HDAC6
Human Protein Atlas	HDAC6
Associated Diseases	Als, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Cancer, Cardiovascular, Diabetes
Known Drugs/Compounds	curcumin, lithium, Ramalin, rapamycin
Interactions	ACAT1, ACTB, Actin, ADCY3, AGING, AGO2
SciDEX Hypotheses	HDAC6 Inhibition for Charcot-Marie-Tooth Disease a HDAC6 Selective Inhibition to Restore Acetylation HDAC6 Inhibition for Dual Restoration of Microtubu (+1 more)
KG Connections	1123 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HDAC6 — AlphaFold Q9UQR8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    HDAC6(["HDAC6"])
    Autophagic_Degradation("Autophagic Degradation")
    P62(["P62"])
    PROTEASOME["PROTEASOME"]
    Alzheimer["Alzheimer"]
    Als["Als"]
    Cancer["Cancer"]
    OPTN(["OPTN"])
    Autophagy["Autophagy"]
    OXIDATIVE_STRESS(["OXIDATIVE STRESS"])
    UBIQUITIN(["UBIQUITIN"])
    Tumor["Tumor"]
    Parkinson["Parkinson"]

    HDAC6 -->|"regulates"| Autophagic_Degradation
    P62 -->|"modulates"| HDAC6
    PROTEASOME -->|"modulates"| HDAC6
    HDAC6 -->|"regulates"| Alzheimer
    HDAC6 -->|"regulates"| Als
    HDAC6 -->|"regulates"| Cancer
    HDAC6 -->|"activates"| Als
    HDAC6 -->|"therapeutic target"| Als
    HDAC6 -->|"interacts with"| OPTN
    HDAC6 -->|"activates"| Autophagy
    HDAC6 -->|"regulates"| OXIDATIVE_STRESS
    HDAC6 -->|"activates"| UBIQUITIN
    HDAC6 -->|"associated with"| Tumor
    HDAC6 -->|"associated with"| Parkinson
    HDAC6 -->|"associated with"| Cancer

    style HDAC6 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (748)

Target	Relation	Type	Str
HDAC6	encodes	protein	0.00
Macroautophagy	involved_in	process	0.95
Autophagosome-Lysosome Fusion	regulates	process	0.90
neurons	expressed_in	cell_type	0.90
CTTN	regulates	gene	0.90
Autophagosome-Lysosome Fusion	promotes	process	0.90
neurodegeneration	inhibits	disease	0.90
alpha-tubulin acetylation	inhibits	process	0.90
Lewy Bodies	component_of	structure	0.90
Tubulin Acetylation	catalyzes	process	0.85
Proteasomal Inhibition	mediates	mechanism	0.85
Synaptic Failure	contributes_to	process	0.85
acetylation	inhibits	process	0.85
Protein Aggregates	degrades	structure	0.85
Parkinson Disease	associated_with	disease	0.85
Memory Restoration	targets	phenotype	0.82
neural stem cells	activates	cell_type	0.80
neural stem cells	regulates	cell_type	0.80
neuroinflammation	inhibits	disease	0.80
neuroinflammation	regulates	disease	0.80
F-actin cytoskeleton	regulates	pathway	0.80
Multiple System Atrophy	associated_with	disease	0.80
P62	interacts_with	protein	0.80
epigenetic regulation	participates_in	pathway	0.80
PIK3C3	regulates	gene	0.80
NLRP3 inflammasome	activates	protein	0.80
Als	regulates	disease	0.75
Alzheimer	regulates	disease	0.75
TAU	associated_with	protein	0.75
Als	activates	disease	0.75
Α-Tubulin	modulates	protein	0.75
Cancer	regulates	disease	0.75
Als	therapeutic_target	disease	0.75
Alzheimer's disease	associated_with	disease	0.70
Alzheimer's disease	inhibits	disease	0.70
STROKE	inhibits	disease	0.70
apoptosis pathway	participates_in	pathway	0.70
Parkinson's disease	activates	disease	0.70
Parkinson's disease	regulates	disease	0.70
Autophagy	activates	pathway	0.70
neurodegeneration	regulates	disease	0.70
OXIDATIVE STRESS	regulates	gene	0.70
ULK1	regulates	gene	0.70
TFEB	regulates	gene	0.70
SQSTM1	regulates	gene	0.70
AMPK signaling	participates_in	pathway	0.70
UBIQUITIN	activates	gene	0.70
OPTN	interacts_with	protein	0.70
MAP1LC3B	regulates	gene	0.70
MTOR	regulates	gene	0.70

Incoming (377)

Source	Relation	Type	Str
HDAC6	encodes	gene	0.00
ISG15	inhibits	gene	0.95
ISG15	binds	gene	0.90
SGK1	upregulates	gene	0.90
h-ca454967	targets_gene	hypothesis	0.90
PIK3C3	phosphorylates	protein	0.80
BACE1	interacts_with	gene	0.80
Ramalin	inhibits	gene	0.70
BACE1	activates	gene	0.70
rapamycin	targets	drug	0.70
ATG	regulates	gene	0.70
AR	activates	gene	0.70
ATG	activates	gene	0.70
BDNF	co_discussed	gene	0.65
BACE1	co_discussed	gene	0.65
MAPT	inhibits	gene	0.65
NEK1	causes	gene	0.65
HIPPOCAMPUS	inhibits	brain_region	0.65
MAPT	treats	gene	0.65
NEURODEGENERATION	inhibits	disease	0.65
STK11	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
STX17	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
TUBB3	associated_with	gene	0.60
CDC42	regulates	gene	0.60
ULK1	associated_with	gene	0.60
KAT5	associated_with	gene	0.60
KAT2B	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
RAB9A	associated_with	gene	0.60
BCL2L1	associated_with	gene	0.60
GLA	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
PSEN2	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
FYCO1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
RB1	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
NRF2	contributes_to	gene	0.60
BECN1	regulates	gene	0.60
CASP3	regulates	gene	0.60
PIK3C3	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
OCLN	associated_with	gene	0.60

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
HDAC6 Inhibition for Charcot-Marie-Tooth Disease and ALS	0.793	neurodegeneration	Test
HDAC6 Activation as SCFA-Mediated Neuroprotective Mechanism	0.682	neurodegeneration	Do SCFAs directly modulate α-synuclein a
HDAC6 Selective Inhibition to Restore Acetylation Balance an	0.643	structural-biology	What is the atomic-resolution structure
Brain-Ester Prodrug Strategy for CNS-Selective HDAC6 Inhibit	0.570	pharmacology	How can CNS-selective HDAC/DNMT inhibito
HDAC6 Inhibition for Dual Restoration of Microtubule Stabili	0.484	neurodegeneration	Which tau PTMs are both disease-specific

HDAC6 Inhibitor Therapy for Pan-Neurodegenerative Protein Ho	0.450	neurodegeneration	Comparative epigenetic signatures across