gene

ATG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1972Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

ATG is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, activates. Associated with AD, ADH, ALI. Connected to 1181 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ATG
Pathways	Autophagy
GeneCards	ATG
Human Protein Atlas	ATG
Associated Diseases	AD, ADH, ALI, AMI, Aging, Als
Known Drugs/Compounds	rapamycin
Interactions	BCL2L13, SNCAIP, ERN1, P62, PINK1, LGALS3
KG Connections	1972 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ATG["ATG"] -->|"regulates"| AUTOPHAGY["AUTOPHAGY"]
    ATG["ATG"] -->|"regulates"| Ischemia["Ischemia"]
    ATG["ATG"] -->|"activates"| Metabolic_Syndrome["Metabolic Syndrome"]
    ATG["ATG"] -->|"regulates"| Ms["Ms"]
    ATG["ATG"] -->|"interacts"| Dementia["Dementia"]
    ATG["ATG"] -->|"interacts"| Alzheimer["Alzheimer"]
    PIK3C3["PIK3C3"] -->|"regulates"| ATG["ATG"]
    RPS6["RPS6"] -->|"regulates"| ATG["ATG"]
    MAP1LC3B["MAP1LC3B"] -->|"regulates"| ATG["ATG"]
    MTOR["MTOR"] -->|"regulates"| ATG["ATG"]
    style ATG fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1407)

Target	Relation	Type	Str
AUTOPHAGY	regulates	pathway	1.00
Autophagy	regulates	pathway	1.00
LC3	interacts_with	gene	1.00
Als	associated_with	disease	1.00
Autophagy	associated_with	pathway	1.00
Autophagy	activates	pathway	1.00
Tumor	activates	disease	1.00
AUTOPHAGY	associated_with	gene	1.00
AUTOPHAGY	activates	gene	1.00
Autophagy	interacts_with	pathway	1.00
MTOR	associated_with	gene	1.00
AUTOPHAGY	interacts_with	gene	1.00
ROS	associated_with	gene	1.00
Tumor	associated_with	disease	0.95
Als	activates	disease	0.95
Als	regulates	disease	0.95
Inflammation	regulates	disease	0.95
Autophagy	involved_in	process	0.95
Non-Alcoholic Fatty Liver Disease	involved_in	disease	0.95
RAS	activates	gene	0.90
ULK1	regulates	gene	0.90
oxidative stress response	participates_in	pathway	0.90
neural stem cells	activates	cell_type	0.90
neural stem cells	regulates	cell_type	0.90
autophagy-related pathways	regulates	pathway	0.90
Mtor	associated_with	pathway	0.90
INFLAMMATION	regulates	gene	0.90
ALS	associated_with	gene	0.90
GENES	regulates	gene	0.90
Als	interacts_with	disease	0.85
Carcinoma	associated_with	disease	0.85
Cancer	associated_with	disease	0.85
Cancer	activates	disease	0.85
Inflammation	inhibits	disease	0.85
Als	inhibits	disease	0.85
Inflammation	activates	disease	0.85
Cancer	regulates	disease	0.85
BECN1	component_of	gene	0.80
ATG13	component_of	gene	0.80
ATG14L	component_of	gene	0.80
ATG5	component_of	gene	0.80
ATG16	component_of	gene	0.80
ATG8	component_of	gene	0.80
ULK1	component_of	gene	0.80
FIP200	component_of	gene	0.80
ATG101	component_of	gene	0.80
ATG1	component_of	gene	0.80
ATG17	component_of	gene	0.80
ATG29	component_of	gene	0.80
ATG31	component_of	gene	0.80

Incoming (565)

Source	Relation	Type	Str
AUTOPHAGY	associated_with	gene	1.00
SQSTM1	associated_with	gene	1.00
BECN1	associated_with	gene	1.00
Autophagosome Formation	associated_with	process	0.90
rapamycin	targets	drug	0.90
C9ORF72	associated_with	gene	0.90
FOXO1	regulates	gene	0.80
AMBRA1	activates	gene	0.80
P62	associated_with	gene	0.80
GPX4	associated_with	gene	0.80
TFEB	associated_with	gene	0.70
PIK3C3	associated_with	gene	0.70
MAP1LC3	associated_with	gene	0.70
OPTN	associated_with	gene	0.70
RB1	associated_with	gene	0.70
GABARAP	associated_with	gene	0.70
ELAVL1	associated_with	gene	0.70
GENES	activates	gene	0.70
RAN	associated_with	gene	0.70
protein kinases	regulates	protein	0.70
small-molecule kinase inhibitors	regulates	drug	0.70
kinase-mediated phosphorylation	regulates	process	0.70
TLR4	regulates	protein	0.70
UBIQUITIN	interacts_with	gene	0.70
TGFB1	associated_with	gene	0.70
LC3	associated_with	gene	0.70
PARKINSON	associated_with	gene	0.70
LYSOSOME	regulates	gene	0.70
UBIQUITIN	activates	gene	0.70
AUTOPHAGY	regulates	gene	0.70
ULK1	associated_with	gene	0.70
AUTOPHAGY	activates	gene	0.70
COL1A1	associated_with	gene	0.70
GFP	associated_with	gene	0.70
APC	activates	gene	0.70
AR	activates	gene	0.70
PIK3C3	regulates	gene	0.60
RPS6	regulates	gene	0.60
MAP1LC3B	regulates	gene	0.60
MTOR	regulates	gene	0.60
CTSD	regulates	gene	0.60
LAMP1	regulates	gene	0.60
MYC	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
EIF4EBP1	regulates	gene	0.60
MFN1	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
ABCD3	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ATG

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Frontotemporal Dementia (FTD) Mechanistic Pathway

Autophagy Mechanisms

Mitophagy Pathway in Neurodegeneration

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

Epigenetic Dysregulation Comparison -- AD/PD/ALS/FTD/HD

Pre-symptomatic Conversion Windows in ALS Genetic Risk Carriers

TYNDASE — Tyndall

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

Autophagy-Lysosomal Impairment Comparison — AD/PD/ALS/FTD/HD

ALS-FTD Spectrum

DCTN1 Protein (Dynactin Subunit 1)

Alpha-Synuclein ESCRT-III Inhibition Mechanism

Proteostasis Network Dysfunction Comparison Across Neurodegenerative Diseases

Autophagy Failure Comparison -- AD/PD/ALS/FTD/HD

Trinucleotide Repeat Expansion Disorders

Granulovacuolar Bodies: Neuronal Defense Mechanism Against Tau Pathology

Golgi Apparatus Stress Comparison Across Neurodegenerative Diseases