protein

BIM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BIM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

410Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

BIM is a protein involved in neurodegeneration research. Key relationships include: interacts with, expressed in, activates. Associated with AD, ALI, ALS. Connected to 193 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolBIM
FunctionBim Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Molecular Weight22 kDa
PathwaysMitophagy, Apoptosis, Autophagy, Mapk, Cell Cycle
GeneCardsBIM
Human Protein AtlasBIM
Associated DiseasesAD, ALI, ALS, Alzheimer, Parkinson
InteractionsMUL1, NDP52, BCL2L13, SNCA, GBA, DRP1
KG Connections410 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (20)

Knowledge base pages for this entity

FOXO1 Protein

protein · 3787 words

er-stress-neurodegeneration

mechanism · 3696 words

Unfolded Protein Response (UPR)

mechanism · 3651 words

Melanotrophs

cell · 3529 words

Cytochrome c Protein

protein · 3387 words

Pathway Diagram

graph TD
    BIM["BIM"]
    BIM -->|"interacts"| Alzheimer["Alzheimer"]
    BIM -->|"interacts"| ALS["ALS"]
    BIM -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    BIM -->|"interacts"| Dementia["Dementia"]
    BIM -->|"interacts"| Cardiovascular["Cardiovascular"]
    BIM -->|"interacts"| Parkinson["Parkinson"]
    BIM -->|"interacts"| MUL1["MUL1"]
    BIM -->|"interacts"| NDP52["NDP52"]
    BIM -->|"interacts"| BCL2L13["BCL2L13"]
    BIM -->|"interacts"| SNCA["SNCA"]
    IFN__["IFN-gamma"] -->|"contributes to"| BIM
    IFN_gamma["IFN-gamma"] -->|"contributes to"| BIM
    BCL2L11["BCL2L11"] -->|"interacts"| BIM
    DNA["DNA"] -->|"interacts"| BIM
    NIX["NIX"] -->|"interacts"| BIM
    HIF1["HIF1"] -->|"interacts"| BIM
    RB1["RB1"] -->|"interacts"| BIM
    NLRP3["NLRP3"] -->|"interacts"| BIM
    PARKINSON["PARKINSON"] -->|"interacts"| BIM
    FMR1["FMR1"] -->|"interacts"| BIM

Outgoing (276)

TargetRelationTypeStr
Alzheimerinteracts_withdisease0.65
ALSinteracts_withdisease0.65
Frontotemporal Dementiainteracts_withdisease0.65
Dementiainteracts_withdisease0.65
Cardiovascularinteracts_withdisease0.65

Incoming (134)

SourceRelationTypeStr
IFN-γcontributes_toprotein0.80
IFN-gammacontributes_toprotein0.80
BCL2L11interacts_withgene0.60
DNAinteracts_withgene0.60
NIXinteracts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found