Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BIM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
BIM is a protein involved in neurodegeneration research. Key relationships include: interacts with, expressed in, activates. Associated with AD, ALI, ALS. Connected to 193 entities in the SciDEX knowledge graph.
| Gene Symbol | BIM |
| Function | Bim Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. |
| Molecular Weight | 22 kDa |
| Pathways | Mitophagy, Apoptosis, Autophagy, Mapk, Cell Cycle |
| GeneCards | BIM |
| Human Protein Atlas | BIM |
| Associated Diseases | AD, ALI, ALS, Alzheimer, Parkinson |
| Interactions | MUL1, NDP52, BCL2L13, SNCA, GBA, DRP1 |
| KG Connections | 410 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
BIM["BIM"]
BIM -->|"interacts"| Alzheimer["Alzheimer"]
BIM -->|"interacts"| ALS["ALS"]
BIM -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
BIM -->|"interacts"| Dementia["Dementia"]
BIM -->|"interacts"| Cardiovascular["Cardiovascular"]
BIM -->|"interacts"| Parkinson["Parkinson"]
BIM -->|"interacts"| MUL1["MUL1"]
BIM -->|"interacts"| NDP52["NDP52"]
BIM -->|"interacts"| BCL2L13["BCL2L13"]
BIM -->|"interacts"| SNCA["SNCA"]
IFN__["IFN-gamma"] -->|"contributes to"| BIM
IFN_gamma["IFN-gamma"] -->|"contributes to"| BIM
BCL2L11["BCL2L11"] -->|"interacts"| BIM
DNA["DNA"] -->|"interacts"| BIM
NIX["NIX"] -->|"interacts"| BIM
HIF1["HIF1"] -->|"interacts"| BIM
RB1["RB1"] -->|"interacts"| BIM
NLRP3["NLRP3"] -->|"interacts"| BIM
PARKINSON["PARKINSON"] -->|"interacts"| BIM
FMR1["FMR1"] -->|"interacts"| BIM| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | interacts_with | disease | 0.65 |
| ALS | interacts_with | disease | 0.65 |
| Frontotemporal Dementia | interacts_with | disease | 0.65 |
| Dementia | interacts_with | disease | 0.65 |
| Cardiovascular | interacts_with | disease | 0.65 |
| Parkinson | interacts_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Traumatic Brain Injury | associated_with | disease | 0.65 |
| Parkinson | activates | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Lymphoma | therapeutic_target | disease | 0.65 |
| Autoimmune | therapeutic_target | disease | 0.65 |
| MUL1 | interacts_with | gene | 0.60 |
| NDP52 | interacts_with | gene | 0.60 |
| BCL2L13 | interacts_with | gene | 0.60 |
| SNCA | interacts_with | gene | 0.60 |
| GBA | interacts_with | gene | 0.60 |
| DRP1 | interacts_with | gene | 0.60 |
| EIF2AK3 | interacts_with | gene | 0.60 |
| CANX | interacts_with | gene | 0.60 |
| ALZHEIMER DISEASE | interacts_with | gene | 0.60 |
| RAS | interacts_with | gene | 0.60 |
| ROS | interacts_with | gene | 0.60 |
| UBIQUITIN | interacts_with | gene | 0.60 |
| DNM1L | interacts_with | gene | 0.60 |
| CTSD | interacts_with | gene | 0.60 |
| ATG | interacts_with | gene | 0.60 |
| HIF1A | interacts_with | gene | 0.60 |
| BNIP3L | interacts_with | gene | 0.60 |
| AMBRA1 | interacts_with | gene | 0.60 |
| NUCLEOPHAGY | interacts_with | gene | 0.60 |
| APOPTOSIS | interacts_with | gene | 0.60 |
| ALZHEIMER | interacts_with | gene | 0.60 |
| ABCD3 | interacts_with | gene | 0.60 |
| NBR1 | interacts_with | gene | 0.60 |
| TAX1BP1 | interacts_with | gene | 0.60 |
| OPTINEURIN | interacts_with | gene | 0.60 |
| SNCAIP | interacts_with | gene | 0.60 |
| CAT | interacts_with | gene | 0.60 |
| EPAS1 | interacts_with | gene | 0.60 |
| JNK | interacts_with | gene | 0.60 |
| RIPK3 | interacts_with | gene | 0.60 |
| G3BP1 | interacts_with | gene | 0.60 |
| FAM134B | interacts_with | gene | 0.60 |
| BCL2 | interacts_with | gene | 0.60 |
| PEX3 | interacts_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| IFN-γ | contributes_to | protein | 0.80 |
| IFN-gamma | contributes_to | protein | 0.80 |
| BCL2L11 | interacts_with | gene | 0.60 |
| DNA | interacts_with | gene | 0.60 |
| NIX | interacts_with | gene | 0.60 |
| HIF1 | interacts_with | gene | 0.60 |
| RB1 | interacts_with | gene | 0.60 |
| NLRP3 | interacts_with | gene | 0.60 |
| PARKINSON | interacts_with | gene | 0.60 |
| FMR1 | interacts_with | gene | 0.60 |
| RB1CC1 | interacts_with | gene | 0.60 |
| PARL | interacts_with | gene | 0.60 |
| EIF2S1 | interacts_with | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | interacts_with | gene | 0.60 |
| ALS | interacts_with | gene | 0.60 |
| CALCOCO2 | interacts_with | gene | 0.60 |
| MIRO1 | interacts_with | gene | 0.60 |
| PTEN | interacts_with | gene | 0.60 |
| MFN1 | interacts_with | gene | 0.60 |
| PERK | interacts_with | gene | 0.60 |
| ATP | interacts_with | gene | 0.60 |
| MITOCHONDRIA | interacts_with | gene | 0.60 |
| PGAM5 | interacts_with | gene | 0.60 |
| MAP1LC3B | interacts_with | gene | 0.60 |
| BECN1 | interacts_with | gene | 0.60 |
| RHOT1 | interacts_with | gene | 0.60 |
| RETREG1 | interacts_with | gene | 0.60 |
| AUTOPHAGY | interacts_with | gene | 0.60 |
| STING1 | interacts_with | gene | 0.60 |
| LC3 | interacts_with | gene | 0.60 |
| MAPK8 | interacts_with | gene | 0.60 |
| EMD | interacts_with | gene | 0.60 |
| DDIT3 | interacts_with | gene | 0.60 |
| OPTN | interacts_with | gene | 0.60 |
| ERN1 | interacts_with | gene | 0.60 |
| PRKN | interacts_with | gene | 0.60 |
| MITOPHAGY | interacts_with | gene | 0.60 |
| HIF | interacts_with | gene | 0.60 |
| AMPK | interacts_with | gene | 0.60 |
| ATM | interacts_with | gene | 0.60 |
| PARKIN | interacts_with | gene | 0.60 |
| P62 | interacts_with | gene | 0.60 |
| DISC1 | interacts_with | gene | 0.60 |
| APOPTOSIS | interacts_with | gene | 0.60 |
| CTSD | interacts_with | gene | 0.60 |
| EPAS1 | interacts_with | gene | 0.60 |
| SQSTM1 | interacts_with | gene | 0.60 |
| DEMENTIA | interacts_with | gene | 0.60 |
| PINK1 | interacts_with | gene | 0.60 |
| PRESENILIN | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||