gene

NLR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NLR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1148Connections
3Hypotheses
1Analyses
50Outgoing
50Incoming

Summary

Page for NLR Family Member X1

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🧬 Gene Info
Gene SymbolNLR
Primary Expressionsubstantia nigra, Substantia Nigra
Amino Acids977 aa
PathwaysNF-κB
GeneCardsNLR
Human Protein AtlasNLR
Associated DiseasesALS, Alzheimer, Cancer, Cardiovascular, Inflammation
Known Drugs/Compoundsrapamycin, dimethyl fumarate
InteractionsNLRP3, TGM2, WAS, MFN1, CANX, PERK
KG Connections1148 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (20)

Knowledge base pages for this entity

nlrc5-protein

protein · 4393 words

Neuroinflammation Across AD, PD, ALS, FTD, and HD

mechanism · 3668 words

nfkb-neurodegeneration

mechanism · 3235 words

NLRP3 Inflammasome Activation Pathway in Neurodegeneration

mechanism · 3200 words

Neuroinflammation in Neurodegeneration

mechanism · 2980 words

Pathway Diagram

graph TD
    NLR["NLR"]
    Alzheimer["Alzheimer"]
    Cardiovascular["Cardiovascular"]
    Parkinson["Parkinson"]
    Dementia["Dementia"]
    Frontotemporal_Dementia["Frontotemporal Dementia"]
    Cancer["Cancer"]
    Fibrosis["Fibrosis"]
    Neurodegeneration["Neurodegeneration"]
    Aging["Aging"]
    Tumor["Tumor"]
    ALS["ALS"]
    Inflammation["Inflammation"]
    Neuroinflammation["Neuroinflammation"]
    NLR <-->|"interacts"| Alzheimer
    NLR <-->|"interacts"| Cardiovascular
    NLR <-->|"interacts"| Parkinson
    NLR <-->|"interacts"| Dementia
    NLR <-->|"interacts"| Frontotemporal_Dementia
    NLR <-->|"interacts"| Cancer
    NLR <-->|"interacts"| Fibrosis
    NLR -.->|"inhibits"| Neurodegeneration
    NLR -.->|"inhibits"| Parkinson
    NLR -.->|"inhibits"| Aging
    NLR -->|"regulates"| Tumor
    NLR -.->|"inhibits"| ALS
    NLR -.->|"inhibits"| Inflammation
    NLR -.-|"associated"| Tumor
    NLR -->|"activates"| Inflammation
    NLR -->|"activates"| Neurodegeneration
    NLR -->|"activates"| Neuroinflammation
    NLR -->|"activates"| Parkinson
    NLR -->|"activates"| Tumor
    NLR -->|"activates"| ALS
    style NLR fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (620)

TargetRelationTypeStr
oxidative stress responseparticipates_inpathway0.90
autophagy pathwayparticipates_inpathway0.90
pyroptosisparticipates_inpathway0.90
ROSactivatesgene0.80
SQSTM1activatesgene0.80

Incoming (528)

SourceRelationTypeStr
ERN1activatesgene0.80
LC3activatesgene0.80
rapamycintargetsdrug0.80
ERN1regulatesgene0.80
LC3regulatesgene0.80

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming 0.607 neurodegeneration What are the mechanisms by which gut mic
Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S 0.599 neurodegeneration What are the mechanisms by which gut mic
NLRP3/Mitophagy Coupling Modulation 0.522 Neuroinflammation Immune atlas neuroinflammation analysis

Mentioning Analyses (1)

Scientific analyses that reference this entity

Lysosomal dysfunction and cathepsin leakage in Alzheimer disease progression

neuroscience | 2026-04-04 | 0 hypotheses

Related Papers (16)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
USP22 suppresses the NLRP3 inflammasome by degrading NLRP3 via ATG5-dependent au [PMID:35900990] ["Di Q", "Zhao X", "Tang H", "Li X", "Xi Autophagy 2023 1
Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861] ["Han X", "Sun S", "Sun Y", "Song Q", "Z Autophagy 2020 1
H4K12 lactylation-regulated NLRP3 is involved in cigarette smoke-accelerated Alz [PMID:39862777] Wang H, Xia H, Bai J, Wang Z, Wang Y et J Hazard Mater 2025 0
The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic [PMID:40826276] Weber ANR, McManus RM, Hornung V, Geyer Nat Immunol 2025 0
Nlrc4 Inflammasome Expression After Acute Myocardial Infarction in Rats. [PMID:40332346] Borim PA, Gatto M, Mota GAF, Meirelles A Int J Mol Sci 2025 0
HSP90β controls NLRP3 autoactivation. [PMID:38416826] Spel L, Hou C, Theodoropoulou K, Zaffalo Sci Adv 2024 0
NLRP3 inflammasome signalling in Alzheimer's disease. [PMID:38565393] McManus RM, Latz E Neuropharmacology 2024 0
P2X7R Modulates NEK7-NLRP3 Interaction to Exacerbate Experimental Autoimmune Pro [PMID:38993566] Chen L, Liu Y, Yue S, Wang H, Chen J et Int J Biol Sci 2024 0
The NLRP3 inflammasome: contributions to inflammation-related diseases. [PMID:37370025] Chen Y, Ye X, Escames G, Lei W, Zhang X Cell Mol Biol Lett 2023 0
Microglia and Alzheimer's Disease. [PMID:36361780] Merighi S, Nigro M, Travagli A, Gessi S Int J Mol Sci 2022 0
Akkermansia muciniphila Alleviates Dextran Sulfate Sodium (DSS)-Induced Acute Co [PMID:34612661] Qu S, Fan L, Qi Y, Xu C, Hu Y et al. Microbiol Spectr 2021 0
Berberine Protects Against NLRP3 Inflammasome via Ameliorating Autophagic Impair [PMID:33584302] Huang S, Liu H, Lin Y, Liu M, Li Y et al Front Pharmacol 2020 0
Human Monocytes Engage an Alternative Inflammasome Pathway. [PMID:27037191] Gaidt MM, Ebert TS, Chauhan D, Schmidt T Immunity 2016 0
Inflammasome and toll-like receptor signaling in human monocytes after successfu [PMID:27260481] Asmussen A, Fink K, Busch HJ, Helbing T, Crit Care 2016 0
Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is respon [PMID:24879148] Guo W, Sun Y, Liu W, Wu X, Guo L et al. Autophagy 2014 0
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS [PMID:23254930] Heneka MT, Kummer MP, Stutz A, Delekate Nature 2013 0