Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NLR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | NLR |
| Primary Expression | substantia nigra, Substantia Nigra |
| Amino Acids | 977 aa |
| Pathways | NF-κB |
| GeneCards | NLR |
| Human Protein Atlas | NLR |
| Associated Diseases | ALS, Alzheimer, Cancer, Cardiovascular, Inflammation |
| Known Drugs/Compounds | rapamycin, dimethyl fumarate |
| Interactions | NLRP3, TGM2, WAS, MFN1, CANX, PERK |
| KG Connections | 1148 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NLR["NLR"]
Alzheimer["Alzheimer"]
Cardiovascular["Cardiovascular"]
Parkinson["Parkinson"]
Dementia["Dementia"]
Frontotemporal_Dementia["Frontotemporal Dementia"]
Cancer["Cancer"]
Fibrosis["Fibrosis"]
Neurodegeneration["Neurodegeneration"]
Aging["Aging"]
Tumor["Tumor"]
ALS["ALS"]
Inflammation["Inflammation"]
Neuroinflammation["Neuroinflammation"]
NLR <-->|"interacts"| Alzheimer
NLR <-->|"interacts"| Cardiovascular
NLR <-->|"interacts"| Parkinson
NLR <-->|"interacts"| Dementia
NLR <-->|"interacts"| Frontotemporal_Dementia
NLR <-->|"interacts"| Cancer
NLR <-->|"interacts"| Fibrosis
NLR -.->|"inhibits"| Neurodegeneration
NLR -.->|"inhibits"| Parkinson
NLR -.->|"inhibits"| Aging
NLR -->|"regulates"| Tumor
NLR -.->|"inhibits"| ALS
NLR -.->|"inhibits"| Inflammation
NLR -.-|"associated"| Tumor
NLR -->|"activates"| Inflammation
NLR -->|"activates"| Neurodegeneration
NLR -->|"activates"| Neuroinflammation
NLR -->|"activates"| Parkinson
NLR -->|"activates"| Tumor
NLR -->|"activates"| ALS
style NLR fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px| Target | Relation | Type | Str |
|---|---|---|---|
| oxidative stress response | participates_in | pathway | 0.90 |
| autophagy pathway | participates_in | pathway | 0.90 |
| pyroptosis | participates_in | pathway | 0.90 |
| ROS | activates | gene | 0.80 |
| SQSTM1 | activates | gene | 0.80 |
| necroptosis | participates_in | pathway | 0.80 |
| ubiquitin-proteasome | participates_in | pathway | 0.80 |
| MAPK signaling | participates_in | pathway | 0.80 |
| neural stem cells | activates | cell_type | 0.80 |
| OPTN | regulates | gene | 0.80 |
| ROS | regulates | gene | 0.80 |
| neural stem cells | regulates | cell_type | 0.80 |
| microglia | activates | cell_type | 0.80 |
| OPTN | activates | gene | 0.70 |
| RB1 | activates | gene | 0.70 |
| RB1CC1 | activates | gene | 0.70 |
| RIPK3 | activates | gene | 0.70 |
| STING1 | activates | gene | 0.70 |
| Alzheimer's disease | activates | disease | 0.70 |
| NRBF2 | activates | gene | 0.70 |
| PI3K | activates | gene | 0.70 |
| STAT3 | activates | gene | 0.70 |
| PI3K-AKT-mTOR signaling | participates_in | pathway | 0.70 |
| stem cells | expressed_in | cell_type | 0.70 |
| macrophages | expressed_in | cell_type | 0.70 |
| PYCARD | activates | gene | 0.70 |
| microglia | expressed_in | cell_type | 0.70 |
| endothelial cells | activates | cell_type | 0.70 |
| PINK1 | regulates | gene | 0.70 |
| PRKN | regulates | gene | 0.70 |
| PTEN | regulates | gene | 0.70 |
| RB1 | regulates | gene | 0.70 |
| RB1CC1 | regulates | gene | 0.70 |
| RIPK3 | regulates | gene | 0.70 |
| STING1 | regulates | gene | 0.70 |
| JAK-STAT signaling | participates_in | pathway | 0.70 |
| dendritic cells | activates | cell_type | 0.70 |
| PI3K | regulates | gene | 0.70 |
| STAT3 | regulates | gene | 0.70 |
| dendritic cells | regulates | cell_type | 0.70 |
| NLRP3 | disrupts | gene | 0.70 |
| neurodegeneration | disrupts | disease | 0.70 |
| NLRP3 | causes | gene | 0.70 |
| unfolded protein response | participates_in | pathway | 0.70 |
| Alzheimer | interacts_with | disease | 0.65 |
| Cardiovascular | interacts_with | disease | 0.65 |
| Parkinson | interacts_with | disease | 0.65 |
| Dementia | interacts_with | disease | 0.65 |
| Frontotemporal Dementia | interacts_with | disease | 0.65 |
| Cancer | interacts_with | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ERN1 | activates | gene | 0.80 |
| LC3 | activates | gene | 0.80 |
| rapamycin | targets | drug | 0.80 |
| ERN1 | regulates | gene | 0.80 |
| LC3 | regulates | gene | 0.80 |
| NBR1 | regulates | gene | 0.80 |
| ATG | activates | gene | 0.70 |
| ATP | activates | gene | 0.70 |
| BECN1 | activates | gene | 0.70 |
| DDIT3 | activates | gene | 0.70 |
| DNA | activates | gene | 0.70 |
| EIF2AK3 | activates | gene | 0.70 |
| FIP200 | activates | gene | 0.70 |
| JNK | activates | gene | 0.70 |
| NBR1 | activates | gene | 0.70 |
| MAPK | activates | gene | 0.70 |
| MTOR | activates | gene | 0.70 |
| ATG | regulates | gene | 0.70 |
| ATP | regulates | gene | 0.70 |
| BCL2 | regulates | gene | 0.70 |
| CALCOCO2 | regulates | gene | 0.70 |
| DDIT3 | regulates | gene | 0.70 |
| DNA | regulates | gene | 0.70 |
| EIF2AK3 | regulates | gene | 0.70 |
| FIP200 | regulates | gene | 0.70 |
| JNK | regulates | gene | 0.70 |
| NDP52 | regulates | gene | 0.70 |
| MAPK | regulates | gene | 0.70 |
| MTOR | regulates | gene | 0.70 |
| MAP1LC3 | regulates | gene | 0.70 |
| LC3 | interacts_with | gene | 0.60 |
| CALCOCO2 | interacts_with | gene | 0.60 |
| CATALASE | interacts_with | gene | 0.60 |
| PRESENILIN | interacts_with | gene | 0.60 |
| BNIP3L | interacts_with | gene | 0.60 |
| MITOCHONDRIA | interacts_with | gene | 0.60 |
| ERN1 | interacts_with | gene | 0.60 |
| LRRK2 | interacts_with | gene | 0.60 |
| WNT | interacts_with | gene | 0.60 |
| RB1 | interacts_with | gene | 0.60 |
| OPTINEURIN | interacts_with | gene | 0.60 |
| FIP200 | interacts_with | gene | 0.60 |
| AKT1 | interacts_with | gene | 0.60 |
| ATF6 | interacts_with | gene | 0.60 |
| CDH1 | interacts_with | gene | 0.60 |
| EGF | interacts_with | gene | 0.60 |
| RAS | interacts_with | gene | 0.60 |
| IL6 | regulates | gene | 0.60 |
| NEURODEGENERATION | inhibits | gene | 0.60 |
| IL1B | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming | 0.607 | neurodegeneration | What are the mechanisms by which gut mic |
| Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S | 0.599 | neurodegeneration | What are the mechanisms by which gut mic |
| NLRP3/Mitophagy Coupling Modulation | 0.522 | Neuroinflammation | Immune atlas neuroinflammation analysis |
Scientific analyses that reference this entity
neuroscience | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| USP22 suppresses the NLRP3 inflammasome by degrading NLRP3 via ATG5-dependent au [PMID:35900990] | ["Di Q", "Zhao X", "Tang H", "Li X", "Xi | Autophagy | 2023 | 1 |
| Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861] | ["Han X", "Sun S", "Sun Y", "Song Q", "Z | Autophagy | 2020 | 1 |
| H4K12 lactylation-regulated NLRP3 is involved in cigarette smoke-accelerated Alz [PMID:39862777] | Wang H, Xia H, Bai J, Wang Z, Wang Y et | J Hazard Mater | 2025 | 0 |
| The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic [PMID:40826276] | Weber ANR, McManus RM, Hornung V, Geyer | Nat Immunol | 2025 | 0 |
| Nlrc4 Inflammasome Expression After Acute Myocardial Infarction in Rats. [PMID:40332346] | Borim PA, Gatto M, Mota GAF, Meirelles A | Int J Mol Sci | 2025 | 0 |
| HSP90β controls NLRP3 autoactivation. [PMID:38416826] | Spel L, Hou C, Theodoropoulou K, Zaffalo | Sci Adv | 2024 | 0 |
| NLRP3 inflammasome signalling in Alzheimer's disease. [PMID:38565393] | McManus RM, Latz E | Neuropharmacology | 2024 | 0 |
| P2X7R Modulates NEK7-NLRP3 Interaction to Exacerbate Experimental Autoimmune Pro [PMID:38993566] | Chen L, Liu Y, Yue S, Wang H, Chen J et | Int J Biol Sci | 2024 | 0 |
| The NLRP3 inflammasome: contributions to inflammation-related diseases. [PMID:37370025] | Chen Y, Ye X, Escames G, Lei W, Zhang X | Cell Mol Biol Lett | 2023 | 0 |
| Microglia and Alzheimer's Disease. [PMID:36361780] | Merighi S, Nigro M, Travagli A, Gessi S | Int J Mol Sci | 2022 | 0 |
| Akkermansia muciniphila Alleviates Dextran Sulfate Sodium (DSS)-Induced Acute Co [PMID:34612661] | Qu S, Fan L, Qi Y, Xu C, Hu Y et al. | Microbiol Spectr | 2021 | 0 |
| Berberine Protects Against NLRP3 Inflammasome via Ameliorating Autophagic Impair [PMID:33584302] | Huang S, Liu H, Lin Y, Liu M, Li Y et al | Front Pharmacol | 2020 | 0 |
| Human Monocytes Engage an Alternative Inflammasome Pathway. [PMID:27037191] | Gaidt MM, Ebert TS, Chauhan D, Schmidt T | Immunity | 2016 | 0 |
| Inflammasome and toll-like receptor signaling in human monocytes after successfu [PMID:27260481] | Asmussen A, Fink K, Busch HJ, Helbing T, | Crit Care | 2016 | 0 |
| Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is respon [PMID:24879148] | Guo W, Sun Y, Liu W, Wu X, Guo L et al. | Autophagy | 2014 | 0 |
| NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS [PMID:23254930] | Heneka MT, Kummer MP, Stutz A, Delekate | Nature | 2013 | 0 |