concept

WNT SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WNT SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

537Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	WNT SIGNALING
Key Genes/Proteins	DNMT3A, PSD95, BDNF
Related Diseases	AUTOPHAGY, MITOCHONDRIAL DYSFUNCTION, NEURODEGENERATION, NEUROGENESIS
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    WNT_SIGNALING["WNT SIGNALING"]
    WNT_SIGNALING -->|"dysregulated_in"| Alzheimer_s_disease["Alzheimer's disease"]
    WNT_SIGNALING -->|"activates"| MYC["MYC"]
    WIF1["WIF1"] -->|"inhibits"| WNT_SIGNALING
    MYC -->|"regulates"| WNT_SIGNALING
    SYNAPSE["SYNAPSE"] -->|"regulates"| WNT_SIGNALING
    SNCA["SNCA"] -->|"regulates"| WNT_SIGNALING
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| WNT_SIGNALING
    SQSTM1["SQSTM1"] -->|"activates"| WNT_SIGNALING
    BECN1["BECN1"] -->|"activates"| WNT_SIGNALING

Outgoing (88)

Target	Relation	Type	Str
DNMT3A	regulates	gene	0.70
NEURAL STEM CELLS	activates	cell_type	0.70
PSD95	inhibits	gene	0.70
AUTOPHAGY	regulates	phenotype	0.65
NEURONS	regulates	cell_type	0.65
MITOCHONDRIAL DYSFUNCTION	interacts_with	phenotype	0.65
NEURODEGENERATION	exacerbates	disease	0.65
NEURODEGENERATION	activates	disease	0.65
NEURODEGENERATION	treats	disease	0.65
NEURONS	inhibits	cell_type	0.65
NEURONS	activates	cell_type	0.65
OLIGODENDROCYTES	regulates	cell_type	0.65
NEUROGENESIS	causes	phenotype	0.65
MITOCHONDRIAL DYSFUNCTION	degrades	phenotype	0.65
WNT3A	activates	gene	0.65
APP	inhibits	gene	0.65
VEGFA	produces	gene	0.65
APOPTOSIS	activates	phenotype	0.65
STEM CELLS	implicated_in	cell_type	0.60
WNT1	expressed_in	gene	0.55
ALZHEIMER'S DISEASE	implicated_in	disease	0.55
NEUROGENESIS	implicated_in	phenotype	0.55
NEURODEGENERATION	implicated_in	disease	0.55
NEUROGENESIS	participates_in	phenotype	0.55
PD-L1	inhibits	concept	0.50
TEMPORAL LOBE	associated_with	concept	0.50
STEM CELLS	associated_with	cell_type	0.50
NEURONS	associated_with	cell_type	0.50
DNMT3A	associated_with	gene	0.50
GSK3B	associated_with	gene	0.50
DENTATE GYRUS	associated_with	brain_region	0.50
BDNF	associated_with	gene	0.50
LITHIUM	associated_with	drug	0.50
APP	associated_with	gene	0.50
PSD95	associated_with	gene	0.50
AUTOPHAGY	associated_with	phenotype	0.50
CANCER	associated_with	disease	0.45
VEGFA	associated_with	gene	0.45
IDH1	associated_with	gene	0.45
TERT	associated_with	gene	0.45
MICROGLIA	associated_with	cell_type	0.45
ASTROCYTE	associated_with	cell_type	0.45
HDAC1	associated_with	gene	0.45
HDAC2	associated_with	gene	0.45
HDAC3	associated_with	gene	0.45
LRP1	associated_with	gene	0.45
CELL DEATH	associated_with	phenotype	0.45
ASTROCYTES	associated_with	cell_type	0.45
APOPTOSIS	associated_with	phenotype	0.45
TH	associated_with	gene	0.45

Incoming (449)

Source	Relation	Type	Str
BDNF	activates	gene	0.70
TH	inhibits	gene	0.65
TH	targets	gene	0.65
LACTATE	inhibits	phenotype	0.65
MICROGLIA	activates	cell_type	0.65
TDP-43	regulates	gene	0.65
REMYELINATION	regulates	phenotype	0.65
LDLR	activates	gene	0.55
RAB7A	activates	gene	0.55
C1Q	involved_in	gene	0.55
CX3CR1	inhibits	gene	0.55
BDNF	expression	gene	0.55
CACNA1G	interacts_with	gene	0.55
CACNA1G	expression	gene	0.55
CACNA1G	activates	gene	0.55
CACNA1G	involved_in	gene	0.55
PVALB	regulates	gene	0.55
NAMPT	involved_in	gene	0.55
AHR	inhibits	gene	0.55
LRP1	involved_in	gene	0.55
SRPK1	activates	gene	0.55
SRPK1	involved_in	gene	0.55
BDNF	involved_in	gene	0.55
PRMT1	activates	gene	0.55
DNMT1	activates	gene	0.55
GJA1	activates	gene	0.55
APOPTOSIS	expressed_in	phenotype	0.55
AUTOPHAGY	activates	process	0.50
SQSTM1	activates	gene	0.50
BECN1	activates	gene	0.50
MTOR	activates	gene	0.50
AMPK	activates	gene	0.50
LC3	activates	gene	0.50
RAS	activates	gene	0.50
CANCER	activates	disease	0.50
MICROGLIA	regulates	cell_type	0.50
ASTROCYTES	regulates	cell_type	0.50
ALZHEIMER'S DISEASE	regulates	disease	0.50
RAPAMYCIN	activates	drug	0.50
MICRORNA REGULATION	activates	process	0.50
TERT	inhibits	gene	0.50
IDH1	inhibits	gene	0.50
VEGFA	inhibits	protein	0.50
MDM4	inhibits	gene	0.50
Immune Checkpoint	inhibits	pathway	0.50
Proteins	inhibits	protein	0.50
cancer	activates	disease	0.50
HIPPO	activates	concept	0.50
ATF4	associated_with	protein	0.50
RUNX2	associated_with	concept	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Inhibitory Neuron-Selective WNT Signaling Restoration	0.390	neurodegeneration	Which cell types show the most significa

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
The Wnt3a/β-catenin/TCF7L2 signaling axis reduces the sensitivity of HER2-positi [PMID:32248976]	Shen G, Gao Q, Liu F, Zhang Y, Dai M et	Biochem Biophys Res Commun	2020
WNT signalling in the normal human adult testis and in male germ cell neoplasms. [PMID:32667987]	Young JC, Kerr G, Micati D, Nielsen JE,	Hum Reprod	2020
Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-cat [PMID:28811361]	Emons G, Spitzner M, Reineke S, Möller J	Mol Cancer Res	2017
Wnt-dependent T-cell factor-4 controls human etravillous trophoblast motility. [PMID:24605829]	Meinhardt G, Haider S, Haslinger P, Proe	Endocrinology	2014
Flt3 tandem duplication mutations cooperate with Wnt signaling in leukemic signa [PMID:15650056]	Tickenbrock L, Schwäble J, Wiedehage M,	Blood	2005

WNT SIGNALING

Understanding Entity Pages

Wiki Pages (20)

Novel Therapy Index

Parthanatos in Neurodegeneration

Therapeutics

NRF2 Oxidative Stress Pathway

GSK-3β in Neurodegeneration

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

blood-brain-barrier

Niemann-Pick Disease Type C (NPC)

MACF1 — Microtubule-actin crosslinking factor 1

Cellular Reprogramming Therapies for Neurodegeneration

FGF10 — Fibroblast Growth Factor 10

NF-kB Signaling Pathway in Neurodegeneration

DDX3X Gene

Neurogenesis

Neurogenesis and Neurodegeneration

LRP1B — Low Density Lipoprotein Receptor-Related Protein 1B

WNT4 Gene

TBX2 — T-Box Transcription Factor 2