gene

PARK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PARK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

478Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

PARK2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, activates. Associated with ALS, Aging, Als. Connected to 270 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PARK2
Full Name	Parkin
Chromosome	6q26
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	52 kDa
Amino Acids	465 aa
Exons	12
Pathways	Apoptosis, Immune Response, Mitophagy
Ensembl ID	ENSG00000185345
GeneCards	PARK2
Human Protein Atlas	PARK2
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, Cancer
Known Drugs/Compounds	levodopa, THSG
Interactions	AGING, ALS, AND, APOPTOSIS, AR, ATG5
KG Connections	478 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    PARK2["PARK2
(Parkin Gene)"]
    PARKIN["PARKIN
(E3 Ubiquitin Ligase)"]
    THSG["THSG
(Therapeutic Compound)"]
    Mitophagy["Mitophagy
(Mitochondrial Clearance)"]
    Autophagy["Autophagy
(Cellular Clearance)"]
    MAP1LC3B["MAP1LC3B
(LC3B)"]
    SQSTM1["SQSTM1
(p62)"]
    DamagedMito["Damaged
Mitochondria"]
    Parkinson["Parkinson's
Disease"]
    Neurodegeneration["Neurodegeneration"]
    ALS["Amyotrophic Lateral
Sclerosis (ALS)"]
    MS["Multiple
Sclerosis"]
    Aging["Aging"]
    
    THSG -->|"activates"| PARK2
    PARK2 -->|"encodes"| PARKIN
    PARK2 -->|"regulates"| Mitophagy
    PARK2 -->|"activates"| Autophagy
    PARK2 -->|"activates"| MAP1LC3B
    PARK2 -->|"associated_with"| SQSTM1
    
    PARKIN -->|"ubiquitinates"| DamagedMito
    DamagedMito -->|"cleared_by"| Mitophagy
    MAP1LC3B -->|"facilitates"| Autophagy
    SQSTM1 -->|"links_to"| Autophagy
    
    PARK2 -->|"inhibits"| Parkinson
    PARK2 -->|"inhibits"| Neurodegeneration
    PARK2 -->|"regulates"| ALS
    PARK2 -->|"inhibits"| MS
    PARK2 -->|"inhibits"| Aging
    
    style PARK2 fill:#006494
    style PARKIN fill:#4a1a6b
    style THSG fill:#1b5e20
    style Mitophagy fill:#1b5e20
    style Autophagy fill:#1b5e20
    style MAP1LC3B fill:#4a1a6b
    style SQSTM1 fill:#4a1a6b
    style DamagedMito fill:#ef5350
    style Parkinson fill:#5d4400
    style Neurodegeneration fill:#5d4400
    style ALS fill:#5d4400
    style MS fill:#5d4400
    style Aging fill:#5d4400

Outgoing (292)

Target	Relation	Type	Str
Mitophagy	mediates	process	0.95
Parkinson's Disease	risk_factor_for	disease	0.95
PINK1	phosphorylates	gene	0.90
neurodegeneration	associated_with	disease	0.90
Mitophagy	associated_with	process	0.90
PRKN	associated_with	gene	0.90
Substantia Nigra Neurodegeneration	protects_against	phenotype	0.88
Als	associated_with	disease	0.85
Parkinson	associated_with	disease	0.85
SNCA	regulates	gene	0.80
Parkinson's disease	implicated_in	disease	0.80
Alzheimer's disease	implicated_in	disease	0.80
Mitophagy	activates	pathway	0.80
Aging	inhibits	disease	0.75
Parkinson	inhibits	disease	0.75
Mitophagy	inhibits	pathway	0.70
Parkinson's disease	interacts_with	disease	0.70
Apoptosis	associated_with	pathway	0.70
Autophagy	associated_with	pathway	0.70
SQSTM1	associated_with	gene	0.70
PARKIN	activates	gene	0.70
PARKIN	encodes	protein	0.70
AUTOPHAGY	associated_with	gene	0.70
AUTOPHAGY	activates	gene	0.70
mitophagy	promotes	process	0.70
UBIQUITIN	associated_with	gene	0.70
mitophagy	regulates	process	0.70
PARKIN	associated_with	gene	0.70
PARKINSON	inhibits	gene	0.70
autophagy pathway	participates_in	pathway	0.70
PARKINSON'S DISEASE	inhibits	gene	0.70
Autophagy	activates	pathway	0.70
PARKINSON	associated_with	gene	0.70
Als	inhibits	disease	0.65
Ischemia	associated_with	disease	0.65
Parkinson	causes	disease	0.65
Ms	inhibits	disease	0.65
Cardiovascular	inhibits	disease	0.65
Melanoma	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Stroke	activates	disease	0.65
Neurodegeneration	causes	disease	0.65
Heart Failure	inhibits	disease	0.65
Cardiovascular	degrades	disease	0.65
Aging	degrades	disease	0.65
ALS	activates	disease	0.65
Als	causes	disease	0.65

Incoming (186)

Source	Relation	Type	Str
h-a11f71b5	targets	hypothesis	0.90
PINK1	phosphorylates	gene	0.90
MANF	binds	protein	0.80
MIDN	regulates	gene	0.80
MIF	inhibits	protein	0.80
GPCPD1	regulates	gene	0.80
MITOPHAGY	activates	gene	0.80
PINK1	activates	gene	0.80
THSG	activates	drug	0.70
MITOPHAGY	inhibits	gene	0.70
PINK1	associated_with	gene	0.70
TP53	associated_with	gene	0.60
PINK1	inhibits	gene	0.60
ERK1	associated_with	gene	0.60
ATXN2	interacts_with	gene	0.60
levodopa	targets	drug	0.60
ATXN2	causes	gene	0.60
ATXN2	activates	gene	0.60
ATXN2	regulates	gene	0.60
NFKB	associated_with	gene	0.60
AGING	inhibits	gene	0.60
PARKINSON'S DISEASE	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
CANCER	associated_with	gene	0.60
ATP13A2	associated_with	gene	0.60
PARK7	associated_with	gene	0.60
MAP1LC3B	interacts_with	entity	0.60
SNCA	associated_with	gene	0.60
APOPTOSIS	activates	gene	0.60
APOPTOSIS	associated_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
NIX	associated_with	gene	0.60
MITOPHAGY	degrades	gene	0.60
AGING	degrades	gene	0.60
GFP	associated_with	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
BRAIN INJURY	degrades	gene	0.60
ROS	associated_with	gene	0.60
PARK1	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
ALZHEIMER DISEASE	associated_with	gene	0.60
mitophagy	regulates	pathway	0.60
BNIP3	activates	gene	0.60
PARKIN	associated_with	gene	0.60
BCL2L13	associated_with	gene	0.60
TOMM20	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
MAP1LC3B	activates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
PINK1/PARK2-Mediated Mitophagy Enhancement for Neuroinflamma	0.571	neuroinflammation	Immune atlas neuroinflammation analysis
PINK1/PARK2-LC3 Mitophagy Enhancement	0.485	neuroinflammation	Immune atlas neuroinflammation analysis
PINK1/PARK2 Mitophagy Enhancement for Microglial Polarizatio	0.380	neuroinflammation	Immune atlas neuroinflammation analysis

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PARK2 in their description or question text

No additional research found

PARK2

Understanding Entity Pages

Summary

Wiki Pages (6)

PARK2 - Parkin

PARK2 Protein

PARK2 — Parkin Gene Entity Page

PARK2/Parkin Ubiquitin Ligase Pathway in Parkinson's Disease

PARK2 Protein - Parkin

Parkin (PARK2)