protein

PKA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PKA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

116Connections

0Hypotheses

1Analyses

49Outgoing

50Incoming

Summary

Page for PKA RIIβ Protein (Protein Kinase A Regulatory Subunit 2B)

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🔬 Protein Info

Gene Symbol	PKA
Aliases	Protein Kinase A Regulatory Subunit 2B
Function	Regulatory Subunit 2B)
Molecular Weight	45.5 kDa
Amino Acids	404 aa
Pathways	unfolded protein response, mitochondrial function, circadian regulation, insulin signaling, MAPK signaling
GeneCards	PKA
Human Protein Atlas	PKA
Associated Diseases	ALS, dementia
Known Drugs/Compounds	rapamycin
Interactions	TGF, TNF, RAMP1, STAT3, VDR, PTEN
KG Connections	116 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PKA["<b>PKA</b>"]
    CREB(["CREB"])
    PKA -->|"activates"| CREB
    JMJD3["JMJD3"]
    PKA -->|"phosphorylates"| JMJD3
    PAK4(["PAK4"])
    PKA -->|"degrades"| PAK4
    MERTK(["MERTK"])
    PKA -->|"activates"| MERTK
    NMDAR2B(["NMDAR2B"])
    NMDAR2B -->|"activates"| PKA
    FGF21(["FGF21"])
    FGF21 -->|"activates"| PKA
    S1P1["S1P1"]
    S1P1 -.->|"downregulates"| PKA
    NEURON(["NEURON"])
    NEURON -->|"activates"| PKA
    style PKA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (49)

Target	Relation	Type	Str
CREB	activates	protein	0.90
PAK4	degrades	protein	0.80
oxidative stress response	participates_in	pathway	0.70
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
neurodegeneration	activates	disease	0.70
unfolded protein response	participates_in	pathway	0.65
neurons	expressed_in	cell_type	0.65
JMJD3	activates	protein	0.64
CREB	phosphorylates	protein	0.60
dementia	associated_with	disease	0.60
ALS	associated_with	disease	0.60
autophagy pathway	participates_in	pathway	0.60
RAMP1	activates	gene	0.60
apoptosis pathway	participates_in	pathway	0.60
pyroptosis	participates_in	pathway	0.60
stroke	activates	disease	0.60
synaptic plasticity	participates_in	pathway	0.60
STAT3	activates	gene	0.60
epigenetic regulation	participates_in	pathway	0.60
PRKACB	associated_with	gene	0.60
autism spectrum disorder	interacts_with	disease	0.60
stem cells	expressed_in	cell_type	0.60
neuroinflammation	activates	disease	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
VDR	interacts_with	gene	0.60
PTEN	activates	gene	0.60
RIPK1	activates	gene	0.60
RNA	activates	gene	0.60
ROS	activates	gene	0.60
TLR	activates	gene	0.60
TNFAIP3	activates	gene	0.60
TRAF6	activates	gene	0.60
TRIM25	activates	gene	0.60
necroptosis	participates_in	pathway	0.60
mitochondrial function	participates_in	pathway	0.55
circadian regulation	participates_in	pathway	0.55
insulin signaling	participates_in	pathway	0.55
MAPK signaling	participates_in	pathway	0.55
prion disease	activates	disease	0.55
TGF	activates	gene	0.55
TNF	activates	gene	0.55
TGF-beta signaling	participates_in	pathway	0.55
NF-kB signaling	participates_in	pathway	0.55
neurotrophin signaling	participates_in	pathway	0.55
microglia	expressed_in	cell_type	0.55
macrophages	expressed_in	cell_type	0.55
astrocytes	expressed_in	cell_type	0.55
MERTK	activates	gene	0.50
SHP2	activates	protein	0.50

Incoming (67)

Source	Relation	Type	Str
NMDAR2B	activates	protein	0.90
FGF21	activates	protein	0.88
BACE1	regulates	gene	0.80
CREB	activates	gene	0.75
AKT	activates	gene	0.60
IRF8	activates	gene	0.60
LXR	activates	gene	0.60
MAPK	activates	gene	0.60
AMPK	activates	gene	0.60
PI3K	activates	gene	0.60
rapamycin	targets	drug	0.60
BACE1	inhibits	gene	0.60
CREB	inhibits	gene	0.60
BACE1	interacts_with	gene	0.60
CREB	interacts_with	gene	0.60
ERK	associated_with	gene	0.60
GAP43	associated_with	gene	0.60
CRH	activates	gene	0.60
HDAC3	activates	gene	0.60
EAAT2	activates	gene	0.60
GFAP	activates	gene	0.60
CREB1	activates	gene	0.60
ASC	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
GSDMD	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
DRP1	protects_against	gene	0.60
AMPK	implicated_in	gene	0.60
PINK1	regulates	gene	0.60
CMKLR1	activates	gene	0.60
ERK	translocates_to	gene	0.60
GAP43	translocates_to	gene	0.60
DRP1	regulates	gene	0.60
ERK1	regulates	gene	0.60
ALS	activates	gene	0.60
FOXO1	activates	gene	0.60
MTNR1A	activates	gene	0.60
ATXN1	phosphorylates	gene	0.60
ATXN1	regulates	gene	0.60
ATXN1	activates	gene	0.60
ATXN1	associated_with	gene	0.60
LAMP2A	activates	gene	0.60
PERK	activates	gene	0.60
MT1	activates	gene	0.55
GLP1R	activates	gene	0.55
GLP1R	inhibits	gene	0.55
JNK	activates	gene	0.55
ADRA2A	activates	gene	0.55
IL-10	activates	gene	0.55
DARPP-32	activates	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the specific molecular mechanisms linking ADCY8 to spatial memory conso

neuroscience | 2026-04-11 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PKA

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

GSK-3β in Neurodegeneration

Autophagy Mechanisms

ncam2

nf1-protein

LRRK2 Pathway in Parkinson's Disease

ZDHHC13 — Zinc Finger DHHC-Type Containing 13

CREB Signaling in Neurodegeneration

Locus Coeruleus Alpha Neurons

NPAS3 Gene

Histamine

mitochondrial-dynamics-dysfunction-parkinsons

Kv7.3 Potassium Channel

tudca-udca-neurodegeneration

Synaptic Plasticity Deficits in Neurodegeneration

SLC30A3 — Solute Carrier Family 30 Member 3 (ZnT3)

ubiquitin-proteasome-dysfunction-neurodegeneration

tau-hyperphosphorylation

Melanotrophs