gene

RNA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RNA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5454Connections
7Hypotheses
16Analyses
50Outgoing
50Incoming

Summary

Page for RNA Binding Fox-1 Homolog 2 (RBFOX2)

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🧬 Gene Info
Gene SymbolRNA
AliasesRBFOX2, RBFOX3, RBFOX1
Chromosome22q12.3
Primary Expressionhippocampus, spinal cord, cortex, cerebellum, prefrontal cortex
Pathwaysunfolded protein response, ferroptosis, PI3K-AKT-mTOR signaling, ubiquitin-proteasome, apoptosis pathway
GeneCardsRNA
Human Protein AtlasRNA
Associated DiseasesALS, Aging, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compoundsquercetin, rapamycin, lecanemab, levodopa, ketamine, dimethyl fumarate
InteractionsTREM2, PTPRC, FUS, GENES, MAPK, WAS
KG Connections5452 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (20)

Knowledge base pages for this entity

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

Corticobasal Syndrome (CBS)

disease · 11374 words

Novel Therapy Index

idea · 10647 words

Parkinson's Disease

disease · 8807 words

Pathway Diagram

graph TD
    subgraph Pathology["Pathology"]
        RNA["RNA"] -->|"associated with"| astrocytes["astrocytes"]
    end
    subgraph Signaling["Signaling"]
        RNA["RNA"] -->|"activates"| microglia["microglia"]
        RNA["RNA"] -->|"activates"| SQSTM1["SQSTM1"]
        RNA["RNA"] -->|"activates"| neurodegeneration["neurodegeneration"]
        RNA["RNA"] -->|"regulates"| neurodegeneration_1["neurodegeneration"]
        m6A_Modification["m6A Modification"] -->|"modulates"| RNA["RNA"]
        BECN1["BECN1"] -->|"activates"| RNA["RNA"]
        rapamycin["rapamycin"] -->|"activates"| RNA["RNA"]
        rapamycin_3["rapamycin"] -->|"regulates"| RNA["RNA"]
        Stress_Granules["Stress Granules"] -->|"regulates"| RNA["RNA"]
    end
    subgraph Therapeutic["Therapeutic"]
        RNA["RNA"] -->|"expressed in"| hippocampus["hippocampus"]
        RNA["RNA"] -->|"expressed in"| spinal_cord["spinal cord"]
        rapamycin_4["rapamycin"] -->|"targets"| RNA["RNA"]
    end
    subgraph Interactions["Interactions"]
        RNA["RNA"] -->|"participates in"| unfolded_protein_response["unfolded protein response"]
        RNA["RNA"] -->|"interacts with"| neurodegeneration_2["neurodegeneration"]
    end
    style RNA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style astrocytes fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style microglia fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style hippocampus fill:#90a4ae,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style unfolded_protein_response fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style SQSTM1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style neurodegeneration fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style neurodegeneration_1 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style spinal_cord fill:#90a4ae,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style neurodegeneration_2 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style m6A_Modification fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style BECN1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style rapamycin fill:#90a4ae,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style rapamycin_3 fill:#90a4ae,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style rapamycin_4 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Stress_Granules fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0

Outgoing (3122)

TargetRelationTypeStr
astrocytesassociated_withcell_type0.90
microgliaactivatescell_type0.90
hippocampusexpressed_inbrain_region0.90
unfolded protein responseparticipates_inpathway0.90
SQSTM1activatesgene0.90

Incoming (2332)

SourceRelationTypeStr
Stress Granulesregulatesprocess0.90
BECN1activatesgene0.90
rapamycintargetsdrug0.90
DNAmodulatesgene0.90
TDP43bindsprotein0.80

Targeting Hypotheses (7)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Closed-loop transcranial alternating current stimulation to 0.639 Alzheimer's disease Circuit-level neural dynamics in neurode
Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re 0.581 neurodegeneration What are the mechanisms by which gut mic
RNA Granule Nucleation Site Modulation 0.479 neurodegeneration TDP-43 phase separation therapeutics for
Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar 0.479 neurodegeneration CRISPR-based therapeutic approaches for
Axonal RNA Transport Reconstitution 0.446 neurodegeneration RNA binding protein dysregulation across
Mitochondrial RNA Granule Rescue Pathway 0.400 neurodegeneration RNA binding protein dysregulation across
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding 0.374 neurodegeneration Protein aggregation cross-seeding across

Mentioning Analyses (16)

Scientific analyses that reference this entity

What are the physiological functions of BACE1 beyond APP processing that could c

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.527

Why does iron chelation therapy worsen outcomes in H63D HFE variant carriers des

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.586

What molecular mechanisms explain how apoE promotes cerebral amyloid angiopathy

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.544

What molecular mechanisms cause iPLA2β deficiency to specifically damage mitocho

neurodegeneration | 2026-04-15 | 0 hypotheses

What molecular mechanisms enable Gal3 to enhance tau fibrillation upon binding t

neurodegeneration | 2026-04-15 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3B [PMID:36692217] Yang C, Wang Z, Kang Y, Yi Q, Wang T, Ba Autophagy 2023 3
G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Gran [PMID:32302571] Yang P, Mathieu C, Kolaitis RM, Zhang P, Cell 2020 3
TDP-43 Pathology in Alzheimer's Disease. [PMID:34930382] Meneses A, Koga S, O'Leary J, Dickson DW Mol Neurodegener 2021 2
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic t [PMID:32048886] Yao RQ, Ren C, Xia ZF, Yao YM Autophagy 2021 2
Protein transmission in neurodegenerative disease. [PMID:32203399] Peng C, Trojanowski JQ, Lee VM Nat Rev Neurol 2020 2
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] Yu CH, Davidson S, Harapas CR, Hilton JB Cell 2020 2
Imp/IGF2BP and Syp/SYNCRIP temporal RNA interactomes uncover combinatorial netwo [PMID:39919181] Lee JY, Huang N, Samuels TJ, Davis I Sci Adv 2025 1
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoi [PMID:37085479] Herrejon Chavez F, Luo H, Cifani P, Pine Nat Commun 2023 1
SIRT6-regulated macrophage efferocytosis epigenetically controls inflammation re [PMID:36593966] Li B, Xin Z, Gao S, Li Y, Guo S, Fu Y, X Theranostics 2023 1
Role of stress granules in modulating senescence and promoting cancer progressio [PMID:34460104] Chatterjee D, Chakrabarti O Int J Cancer 2022 1
Rare deleterious mutations of HNRNP genes result in shared neurodevelopmental di [PMID:33874999] Gillentine MA, Wang T, Hoekzema K, Rosen Genome Med 2021 1
Multisystem proteinopathy: Where myopathy and motor neuron disease converge. [PMID:33145792] Korb MK, Kimonis VE, Mozaffar T Muscle Nerve 2021 1
The role of m6A modification in the biological functions and diseases. [PMID:33611339] Jiang X, Liu B, Nie Z, Duan L, Xiong Q, Signal Transduct Target Ther 2021 1
Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specifi [PMID:34739333] Gwon Y, Maxwell BA, Kolaitis RM, Zhang P Science 2021 1
Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liv [PMID:33213490] Senlin Zhao, Yushuai Mi, Bingjie Guan, B Journal of hematology & oncolo 2020 1
Rare Inherited forms of Paget's Disease and Related Syndromes. [PMID:30756140] Ralston SH, Taylor JP Calcif Tissue Int 2019 1
Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Sta [PMID:41957537] Feng X, Xiao J, Huang C, Jiang BC, Wang Adv Sci (Weinh) 2026 0
ALS-related proteinopathies: From TDP-43 to mitochondrial proteinopathies. [PMID:41570741] Genin EC, Paquis-Flucklinger V Current opinion in neurobiolog 2026 0
Refolding-assisted purification of native full-length TDP-43 compatible with BSL [PMID:41692368] Dehury S, Tiwari S, Los Rios P Methods 2026 0
Small heat shock proteins HspB1 and HspB5 differentially alter the condensation [PMID:41854301] Walker TB, Trowbridge JW, McMahon S, Mar Protein Sci 2026 0