protein

EIF2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EIF2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

535Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

Summary

EIF2A is a protein involved in neurodegeneration research. Key relationships include: interacts with, activates, inhibits. Associated with ALS, Aging, Als. Connected to 296 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	EIF2A
Full Name	Eukaryotic Translation Initiation Factor 2A
Chromosome	3q27.1
Function	Binds the 40S ribosomal subunit
Pathways	Akt, Apoptosis, Er Stress, Wnt
UniProt ID	Q9Y5Q3
NCBI Gene ID	27185
Ensembl ID	ENSG00000144895
OMIM	609994
GeneCards	EIF2A
Human Protein Atlas	EIF2A
Encoded Protein	eIF2A
Associated Diseases	neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	LRRK2, ATG16L1, RB1CC1, GABARAP, ERN1, STAT3
KG Connections	534 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: EIF2A — AlphaFold Q9Y5Q3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    EIF2A["EIF2A"] -->|"regulates"| stress_granules["stress granules"]
    EIF2A["EIF2A"] -->|"interacts"| Cancer["Cancer"]
    EIF2A["EIF2A"] -->|"interacts"| Als["Als"]
    EIF2A["EIF2A"] -->|"interacts"| Ms["Ms"]
    EIF2A["EIF2A"] -->|"interacts"| Fibrosis["Fibrosis"]
    EIF2A["EIF2A"] -->|"interacts"| Aging["Aging"]
    OPTN["OPTN"] -->|"interacts"| EIF2A["EIF2A"]
    CASP3["CASP3"] -->|"interacts"| EIF2A["EIF2A"]
    AKT1["AKT1"] -->|"interacts"| EIF2A["EIF2A"]
    CALCOCO2["CALCOCO2"] -->|"interacts"| EIF2A["EIF2A"]
    style EIF2A fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (351)

Target	Relation	Type	Str
protein synthesis	regulates	process	0.90
Protein Translation	regulates	process	0.85
Endoplasmic Reticulum Stress	involved_in	process	0.85
autophagy pathway	participates_in	pathway	0.80
Endoplasmic Reticulum Stress	biomarker_for	process	0.75
Als	activates	disease	0.75
stress granules	regulates	process	0.70
oxidative stress response	participates_in	pathway	0.70
Cancer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
Aging	interacts_with	disease	0.65
Ms	activates	disease	0.65
Als	regulates	disease	0.65
Fibrosis	regulates	disease	0.65
Aging	regulates	disease	0.65
Cancer	regulates	disease	0.65
Als	contributes_to	disease	0.65
Heart Failure	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Ms	regulates	disease	0.65
Ischemia	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
ALS	activates	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
LRRK2	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
MAPK14	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
ATF6	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
HSP70	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60
MAP1LC3A	interacts_with	gene	0.60

Incoming (184)

Source	Relation	Type	Str
TMTD	phosphorylates	compound	0.90
PERK	phosphorylates	protein	0.85
Stress Granules	phosphorylates	process	0.85
DTG	upregulates	drug	0.85
rapamycin	targets	drug	0.70
OPTN	interacts_with	gene	0.60
CASP3	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
GABARAP	associated_with	gene	0.60
ATF4	associated_with	gene	0.60
FMR1	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
RRAGA	interacts_with	gene	0.60
G3BP1	associated_with	gene	0.60
JUN	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
RRAGB	interacts_with	gene	0.60
TIA1	associated_with	gene	0.60
ATM	activates	gene	0.60
GABARAP	interacts_with	gene	0.60
P38	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
ATF6	interacts_with	gene	0.60
HSPA5	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
PTEN	activates	gene	0.60
PI3K	activates	gene	0.60
AKT1	regulates	gene	0.60
AKT	contributes_to	gene	0.60
CASP9	contributes_to	gene	0.60
MTOR	activates	gene	0.60
ATG12	activates	gene	0.60
BNIP3	inhibits	gene	0.60
VDAC1	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

EIF2A

Understanding Entity Pages

Summary

Wiki Pages (21)

EIF2A Gene

CBS/PSP Genetic Architecture

PKR Pathway in Neurodegeneration

C9orf72→RNA/Dipeptide Repeat Pathology→ALS/FTD — Causal Chain

timm17a

RAN Gene

CASP9 (Caspase 9)

ATF6 - Activating Transcription Factor 6

EIF2AK3 Protein (PERK)

RPS16 — Ribosomal Protein S16

RQC Restoration Therapy for Neurodegeneration

BiP - Binding Immunoglobulin Protein (GRP78)

ATF4 Protein

PKR Protein (Protein Kinase R)

EIF2α Protein

PERK Protein

EIF2S1 (eIF2α)

TIMM22 Protein

RPL31 Protein

RHEB Protein