Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about UBIQUITIN-PROTEASOME: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
UBIQUITIN-PROTEASOME is a concept in neurodegeneration research. Key relationships include: co discussed, activates, stabilizes. Associated with FRONTOTEMPORAL. Connected to 16 entities in the SciDEX knowledge graph.
| Name | UBIQUITIN-PROTEASOME |
| Key Genes/Proteins | VALOSIN, NEURON, RELA, MYOT, ATG, CHMP2B |
| Related Diseases | ALS, NEURODEGENERATIVE DISEASES, LATE, FTD, FRONTOTEMPORAL DEMENTIA |
| Related Pathways | MTOR |
Knowledge base pages for this entity
graph TD
UBIQUITIN_PROTEASOME["UBIQUITIN-PROTEASOME"]
UBIQUITIN_PROTEASOME -->|"interacts"| Unfolded_Protein_Response["Unfolded Protein Response"]
UBIQUITIN_PROTEASOME -->|"interacts"| Mtor["Mtor"]
OCLN["OCLN"] -->|"activates"| UBIQUITIN_PROTEASOME
BECN1["BECN1"] -->|"activates"| UBIQUITIN_PROTEASOME
CLDN5["CLDN5"] -->|"activates"| UBIQUITIN_PROTEASOME
CAV1["CAV1"] -->|"activates"| UBIQUITIN_PROTEASOME
HIF1A["HIF1A"] -->|"activates"| UBIQUITIN_PROTEASOME
ACTB["ACTB"] -->|"regulates"| UBIQUITIN_PROTEASOME
CDC42["CDC42"] -->|"regulates"| UBIQUITIN_PROTEASOME
CASP3["CASP3"] -->|"regulates"| UBIQUITIN_PROTEASOME
SQSTM1["SQSTM1"] -->|"regulates"| UBIQUITIN_PROTEASOME
TUBB3["TUBB3"] -->|"regulates"| UBIQUITIN_PROTEASOME| Target | Relation | Type | Str |
|---|---|---|---|
| VALOSIN | co_discussed | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NEURON | co_discussed | gene | 0.40 |
| ALS | co_discussed | disease | 0.40 |
| RELA | co_discussed | gene | 0.40 |
| NEURODEGENERATIVE DISEASES | co_discussed | disease | 0.40 |
| MYOT | co_discussed | gene | 0.40 |
| LATE | co_discussed | disease | 0.40 |
| ATG | co_discussed | gene | 0.40 |
| CHMP2B | co_discussed | gene | 0.40 |
| FTD | co_discussed | disease | 0.40 |
| FRONTOTEMPORAL DEMENTIA | co_discussed | disease | 0.40 |
| LC3 | co_discussed | protein | 0.40 |
| ACTIN | co_discussed | protein | 0.40 |
| MAP1LC3 | co_discussed | gene | 0.40 |
| MTOR | co_discussed | pathway | 0.40 |
| RAPAMYCIN | co_discussed | drug | 0.40 |
| PINK1 | co_discussed | gene | 0.40 |
| PTEN | co_discussed | gene | 0.40 |
| SPHK1 | co_discussed | gene | 0.40 |
| TARDBP/TDP-43 | co_discussed | protein | 0.40 |
| TAR | co_discussed | protein | 0.40 |
| DNA | co_discussed | protein | 0.40 |
| TBK1 | co_discussed | gene | 0.40 |
| TFEB | co_discussed | protein | 0.40 |
| UNFOLDED PROTEIN RESPONSE | co_discussed | pathway | 0.40 |
| ENDOTHELIAL CELLS | activates | cell_type | 0.35 |
| TDP-43 | activates | gene | 0.35 |
| SURVIVIN | activates | gene | 0.35 |
| NEURON | associated_with | cell_type | 0.35 |
| CANCER | implicated_in | disease | 0.35 |
| GLYCOLYSIS | activates | process | 0.35 |
| GSH | activates | gene | 0.35 |
| AUTOPHAGY | implicated_in | process | 0.35 |
| LRRK2 | implicated_in | gene | 0.35 |
| PROTEIN FOLDING | regulates | process | 0.35 |
| RAPAMYCIN | activates | drug | 0.35 |
| STEM CELLS | activates | cell_type | 0.35 |
| IPSC | activates | cell_type | 0.35 |
| AUTOPHAGY | depletes | process | 0.35 |
| P62 | depletes | gene | 0.35 |
| CHAPERONE-MEDIATED AUTOPHAGY | regulates | process | 0.35 |
| TP53 | activates | gene | 0.30 |
| OPTN | regulates | gene | 0.30 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||