protein

FN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

358Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

FN1 is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, interacts with. Associated with ALS, Aging, Als. Connected to 248 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	FN1
Function	Fibronectin (FN1) is a high-molecular-weight extracellular matrix glycoprotein that plays crucial roles in cell adhesion, migration, and tissue morphogenesis.
Primary Expression	Hippocampus
Pathways	Akt, Pi3K, Angiogenesis, Epigenetic, Immune Response
GeneCards	FN1
Human Protein Atlas	FN1
Associated Diseases	Aging, Als, Carcinoma, Diabetes, Fibrosis
Interactions	ACTB, ACTG1, ADORA2B, AKT, Amyloid, AND
KG Connections	358 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (9)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    FN1["FN1"]
    FN1 -.protects against.-> APOE4["APOE4"]
    FN1 -->|"component_of"| blood_brain_barrier["blood-brain barrier"]
    FN1 -.protects against.-> Alzheimer_s_disease["Alzheimer's disease"]
    FN1 -->|"causes"| gliosis["gliosis"]
    FN1 -->|"target for"| Glioblastoma["Glioblastoma"]
    FN1 -->|"target for"| Als["Als"]
    FN1 -->|"regulates"| Tumor["Tumor"]
    FN1 -->|"target for"| Ms["Ms"]
    APOE4 -->|"contributes to"| FN1
    ANXA2["ANXA2"] -->|"regulates"| FN1
    PI3K["PI3K"] -->|"target for"| FN1
    AKT["AKT"] -->|"activates"| FN1
    AGING["AGING"] -.protects against.-> FN1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -.protects against.-> FN1
    CEBPD["CEBPD"] -->|"activates"| FN1
    EGFR["EGFR"] -->|"activates"| FN1
    GBM["GBM"] -->|"regulates"| FN1

Outgoing (236)

Target	Relation	Type	Str
blood-brain barrier	component_of	phenotype	0.90
APOE4	protects_against	gene	0.90
Als	activates	disease	0.85
Glioblastoma Invasion	modulates	phenotype	0.80
gliosis	causes	phenotype	0.80
Alzheimer's disease	protects_against	disease	0.80
Als	inhibits	disease	0.75
Glioblastoma	activates	disease	0.75
blood-brain barrier integrity	associated_with	process	0.75
GBM	regulates	gene	0.70
GLIOBLASTOMA	activates	gene	0.70
Angiogenesis	activates	pathway	0.70
GENES	activates	gene	0.70
Glioblastoma	therapeutic_target	disease	0.65
Tumor	inhibits	disease	0.65
Prostate Cancer	inhibits	disease	0.65
ALS	activates	disease	0.65
Fibrosis	expressed_in	disease	0.65
Hepatocellular Carcinoma	associated_with	disease	0.65
Cancer	inhibits	disease	0.65
Diabetes	biomarker_for	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Alzheimer	protects_against	disease	0.65
Aging	associated_with	disease	0.65
Als	biomarker_for	disease	0.65
Huntington	therapeutic_target	disease	0.65
Diabetes	expressed_in	disease	0.65
Diabetes	activates	disease	0.65
Carcinoma	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	biomarker_for	disease	0.65
Ms	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Dementia	protects_against	disease	0.65
Tumor	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Alzheimer	expressed_in	disease	0.65
Ms	interacts_with	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Carcinoma	interacts_with	disease	0.65
Inflammation	inhibits	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Aging	expressed_in	disease	0.65
Aging	protects_against	disease	0.65
Als	protects_against	disease	0.65
Ms	activates	disease	0.65

Incoming (122)

Source	Relation	Type	Str
APOE4	contributes_to	gene	0.80
SQSTM1	associated_with	gene	0.60
TNF	associated_with	gene	0.60
ELAVL1	associated_with	gene	0.60
GPX4	associated_with	gene	0.60
ATG	associated_with	gene	0.60
EGFR	interacts_with	gene	0.60
HSP90AA1	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
CCT2	interacts_with	gene	0.60
ACTG1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
GAPDH	interacts_with	gene	0.60
ADORA2B	activates	gene	0.60
INFLAMMATION	inhibits	gene	0.60
IL5	inhibits	gene	0.60
CD44	biomarker_for	gene	0.60
IGF1	biomarker_for	gene	0.60
EGF	biomarker_for	gene	0.60
IMMUNE INFILTRATION	biomarker_for	gene	0.60
KDR	biomarker_for	gene	0.60
DIABETES MELLITUS	biomarker_for	gene	0.60
FGF9	biomarker_for	gene	0.60
HSPG2	biomarker_for	gene	0.60
MTOR	activates	gene	0.60
GENES	regulates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
SOD1	interacts_with	gene	0.60
HUNTINGTON	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
PSMD14	interacts_with	gene	0.60
PHIP	regulates	gene	0.60
GLUT3	regulates	gene	0.60
GBP2	regulates	gene	0.60
ALS	biomarker_for	gene	0.60
CD44	activates	gene	0.60
GFAP	activates	gene	0.60
TP53	associated_with	gene	0.60
NCOA4	associated_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
ZFP36	associated_with	gene	0.60
MAP1LC3A	associated_with	gene	0.60
P53	associated_with	gene	0.60
FERROPTOSIS	interacts_with	gene	0.60
ALZHEIMER DISEASE	causes	gene	0.60
C1QA	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FN1 in their description or question text

No additional research found

FN1

Understanding Entity Pages

Summary

Wiki Pages (9)

LRFN1 — Leucine Rich Repeat and Fibronectin Type III Domain Containing 1

PFN1 — Profilin 1

Mitofusin (MFN1/2) Neurons

PFN1 Gene

Mitofusin 1 (MFN1)

PFN1 Protein

MFN1 Protein

FN1 Protein (Fibronectin)