Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DMSO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DMSO is a concept in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with Als, Alzheimer, Cancer. Connected to 122 entities in the SciDEX knowledge graph.
| Name | DMSO |
| Key Genes/Proteins | CASP3, LC3, MAP1LC3 |
| Related Diseases | Ms, Tumor, Leukemia, Inflammation, Alzheimer |
| Related Pathways | Mtor, Autophagy, oxidative stress response, autophagy pathway, PI3K-AKT-mTOR signaling |
Knowledge base pages for this entity
graph TD
DMSO["DMSO"]
DMSO -->|"causes"| CASP3["CASP3"]
DMSO -->|"activates"| Ms["Ms"]
DMSO -->|"expressed in"| Tumor["Tumor"]
DMSO -->|"activates"| Leukemia["Leukemia"]
DMSO -->|"target for"| Inflammation["Inflammation"]
DMSO -->|"target for"| Alzheimer["Alzheimer"]
DMSO -->|"target for"| Als["Als"]
DMSO -->|"target for"| Neuroinflammation["Neuroinflammation"]
DMSO -->|"activates"| Ischemia["Ischemia"]
DMSO -->|"activates"| Neurodegeneration["Neurodegeneration"]
CTSD["CTSD"] -->|"activates"| DMSO
CLN3["CLN3"] -->|"target for"| DMSO
MTOR["MTOR"] -->|"activates"| DMSO
P62["P62"] -->|"activates"| DMSO
TUBULIN["TUBULIN"] -->|"activates"| DMSO
JUN["JUN"] -->|"activates"| DMSO
LC3["LC3"] -->|"activates"| DMSO
LYSOSOMAL_BIOGENESIS["LYSOSOMAL BIOGENESIS"] -->|"activates"| DMSO
SQSTM1["SQSTM1"] -->|"activates"| DMSO
NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"] -->|"activates"| DMSO| Target | Relation | Type | Str |
|---|---|---|---|
| CASP3 | causes | gene | 0.70 |
| LC3 | associated_with | gene | 0.70 |
| Mtor | associated_with | pathway | 0.70 |
| Autophagy | associated_with | pathway | 0.70 |
| MAP1LC3 | associated_with | gene | 0.70 |
| oxidative stress response | participates_in | pathway | 0.70 |
| autophagy pathway | participates_in | pathway | 0.70 |
| PI3K-AKT-mTOR signaling | participates_in | pathway | 0.70 |
| Ms | activates | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Leukemia | activates | disease | 0.65 |
| Inflammation | therapeutic_target | disease | 0.65 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Neuroinflammation | therapeutic_target | disease | 0.65 |
| Ischemia | activates | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Alzheimer | inhibits | disease | 0.65 |
| Cancer | inhibits | disease | 0.65 |
| Neuroinflammation | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Aging | inhibits | disease | 0.65 |
| Neurodegeneration | inhibits | disease | 0.65 |
| TNF | expressed_in | gene | 0.60 |
| ZFP36L2 | expressed_in | gene | 0.60 |
| ZFP36 | expressed_in | gene | 0.60 |
| IL12B | expressed_in | gene | 0.60 |
| LYSOSOMAL BIOGENESIS | activates | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| EGF | associated_with | gene | 0.60 |
| ENDOSOMES | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| TSC2 | activates | gene | 0.60 |
| MTORC1 | activates | gene | 0.60 |
| TFEB | activates | gene | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| Endocytosis | activates | pathway | 0.60 |
| Akt | activates | pathway | 0.60 |
| BAX | activates | gene | 0.60 |
| P53 | activates | gene | 0.60 |
| MYC | activates | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| BCL-2 | activates | gene | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| ERK | therapeutic_target | gene | 0.60 |
| MICROGLIA | therapeutic_target | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GFP | associated_with | gene | 0.70 |
| rapamycin | targets | drug | 0.70 |
| MAP1LC3 | associated_with | gene | 0.60 |
| MTOR | associated_with | gene | 0.60 |
| CTSD | activates | gene | 0.60 |
| CLN3 | therapeutic_target | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| P62 | activates | gene | 0.60 |
| TUBULIN | activates | gene | 0.60 |
| JUN | activates | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| LYSOSOME | associated_with | gene | 0.60 |
| LYSOSOMAL BIOGENESIS | activates | gene | 0.60 |
| CTSD | associated_with | gene | 0.60 |
| SQSTM1 | activates | gene | 0.60 |
| NEURODEGENERATIVE DISORDERS | activates | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| ACTB | associated_with | gene | 0.60 |
| TUBB3 | activates | gene | 0.60 |
| CTSB | associated_with | gene | 0.60 |
| NEURODEGENERATION | activates | gene | 0.60 |
| SNAP25 | activates | gene | 0.60 |
| MAP2 | activates | gene | 0.60 |
| TSC2 | activates | gene | 0.60 |
| TFEB | activates | gene | 0.60 |
| PNPLA6 | associated_with | gene | 0.60 |
| BAX | associated_with | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| APOPTOSIS | associated_with | gene | 0.60 |
| BECN1 | associated_with | gene | 0.60 |
| RPS6 | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 0.60 |
| NLRP3 | therapeutic_target | gene | 0.60 |
| CXCL10 | therapeutic_target | gene | 0.60 |
| DISEASE-ASSOCIATED MICROGLIA | therapeutic_target | gene | 0.60 |
| RAS | therapeutic_target | gene | 0.60 |
| CX3CR1 | therapeutic_target | gene | 0.60 |
| GPNMB | therapeutic_target | gene | 0.60 |
| NEUROINFLAMMATION | therapeutic_target | gene | 0.60 |
| P2RY12 | therapeutic_target | gene | 0.60 |
| TAU | therapeutic_target | gene | 0.60 |
| ASTROCYTES | therapeutic_target | gene | 0.60 |
| MICROGLIA | therapeutic_target | gene | 0.60 |
| ERK | therapeutic_target | gene | 0.60 |
| C1QA | therapeutic_target | gene | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
| AND | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| ENDOSOMES | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||