concept

DMSO

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DMSO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

334Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

DMSO is a concept in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with Als, Alzheimer, Cancer. Connected to 122 entities in the SciDEX knowledge graph.

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💡 Concept Info
NameDMSO
Key Genes/ProteinsCASP3, LC3, MAP1LC3
Related DiseasesMs, Tumor, Leukemia, Inflammation, Alzheimer
Related PathwaysMtor, Autophagy, oxidative stress response, autophagy pathway, PI3K-AKT-mTOR signaling

Wiki Pages (20)

Knowledge base pages for this entity

Epigenetic-Metabolic Coupling: SIRT1 Activator + NAD+ Precursor

idea · 3877 words

mitochondrial-dynamics-dysfunction-parkinsons

general · 3785 words

Alpha-Synuclein Spreading Mechanism — Prion-Like Propagation and Neurodegeneration

experiment · 2761 words

ZFP36L2 — Zinc Finger Protein L2

gene · 2609 words

Mitochondrial Dysfunction in Glial Cells

mechanism · 2561 words

Pathway Diagram

graph TD
    DMSO["DMSO"]
    DMSO -->|"causes"| CASP3["CASP3"]
    DMSO -->|"activates"| Ms["Ms"]
    DMSO -->|"expressed in"| Tumor["Tumor"]
    DMSO -->|"activates"| Leukemia["Leukemia"]
    DMSO -->|"target for"| Inflammation["Inflammation"]
    DMSO -->|"target for"| Alzheimer["Alzheimer"]
    DMSO -->|"target for"| Als["Als"]
    DMSO -->|"target for"| Neuroinflammation["Neuroinflammation"]
    DMSO -->|"activates"| Ischemia["Ischemia"]
    DMSO -->|"activates"| Neurodegeneration["Neurodegeneration"]
    CTSD["CTSD"] -->|"activates"| DMSO
    CLN3["CLN3"] -->|"target for"| DMSO
    MTOR["MTOR"] -->|"activates"| DMSO
    P62["P62"] -->|"activates"| DMSO
    TUBULIN["TUBULIN"] -->|"activates"| DMSO
    JUN["JUN"] -->|"activates"| DMSO
    LC3["LC3"] -->|"activates"| DMSO
    LYSOSOMAL_BIOGENESIS["LYSOSOMAL BIOGENESIS"] -->|"activates"| DMSO
    SQSTM1["SQSTM1"] -->|"activates"| DMSO
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"] -->|"activates"| DMSO

Outgoing (220)

TargetRelationTypeStr
CASP3causesgene0.70
LC3associated_withgene0.70
Mtorassociated_withpathway0.70
Autophagyassociated_withpathway0.70
MAP1LC3associated_withgene0.70

Incoming (114)

SourceRelationTypeStr
GFPassociated_withgene0.70
rapamycintargetsdrug0.70
MAP1LC3associated_withgene0.60
MTORassociated_withgene0.60
CTSDactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found