protein

TAR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TAR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

161Connections

30Hypotheses

13Analyses

50Outgoing

50Incoming

12Experiments

19Debates

Summary

Page for TAR DNA-Binding Protein 43 (TDP-43)

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🔬 Protein Info

Gene Symbol	TAR
Aliases	TDP-43
Chromosome	1p36.22
Molecular Weight	44.7 kDa
Amino Acids	414 aa
Pathways	oxidative stress response, UNFOLDED PROTEIN RESPONSE, UBIQUITIN-PROTEASOME
GeneCards	TAR
Human Protein Atlas	TAR
Associated Diseases	ALS, Alzheimer, dementia, frontotemporal, neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	ALS, AMPK, AR, ATG, ATXN2, BAG3
KG Connections	161 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (13)

Knowledge base pages for this entity

Synaptic Therapy Alzheimer's Research Trial (START): A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of CT1812 in Early Alzheimer's Disease (NCT05531656)

clinical · 1758 words

→

SL-START - SubLingual Apomorphine Schemes of TitrAtion in Real-world Treatment

clinical · 1457 words

→

Pathway Diagram

graph TD
    TAR["TAR"]
    TDP_43(["TDP-43"])
    TAR -->|"interacts_with"| TDP_43
    WAS(["WAS"])
    TAR -->|"co_discussed"| WAS
    FUS(["FUS"])
    TAR -->|"interacts_with"| FUS
    RNA(["RNA"])
    TAR -->|"regulates"| RNA
    GENES(["GENES"])
    TAR -->|"regulates"| GENES
    TBK1(["TBK1"])
    TAR -->|"regulates"| TBK1
    DNA(["DNA"])
    DNA -->|"co_discussed"| TAR
    NEAT1(["NEAT1"])
    NEAT1 -->|"co_discussed"| TAR
    NEURON(["NEURON"])
    NEURON -->|"co_discussed"| TAR
    style TAR fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (59)

Target	Relation	Type	Str
oxidative stress response	participates_in	pathway	0.85
neurodegeneration	interacts_with	disease	0.85
frontotemporal dementia	interacts_with	disease	0.75
ALS	interacts_with	disease	0.75
TARDBP	regulates	gene	0.75
TDP-43	regulates	gene	0.75
VCP	interacts_with	gene	0.60
autophagy pathway	participates_in	pathway	0.60
ULK1	activates	gene	0.60
WDR41	activates	gene	0.60
TDP43	regulates	gene	0.60
TDP43	interacts_with	gene	0.60
Alzheimer's disease	activates	disease	0.60
Notch signaling	participates_in	pathway	0.60
ALS	regulates	disease	0.60
VCP	regulates	gene	0.60
dementia	associated_with	disease	0.60
frontotemporal	associated_with	disease	0.60
TARDBP	activates	gene	0.60
TFEB	activates	gene	0.60
TPP1	activates	gene	0.60
TREH	activates	gene	0.60
Parkinson's disease	activates	disease	0.60
neurodegeneration	activates	disease	0.60
ALS	activates	disease	0.60
Huntington's disease	activates	disease	0.60
TMEM106B	interacts_with	gene	0.60
ALS	associated_with	disease	0.60
neurodegeneration	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
TBK1	activates	gene	0.60
VCP	activates	gene	0.60
frontotemporal dementia	activates	disease	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
TAX1BP1	interacts_with	gene	0.60
Huntington's disease	interacts_with	disease	0.60
neurodegeneration	regulates	disease	0.60
DAM microglia	expressed_in	cell_type	0.55
stem cells	expressed_in	cell_type	0.55
TARDBP	interacts_with	gene	0.55
Parkinson's disease	interacts_with	disease	0.55
neurons	expressed_in	cell_type	0.55
Alzheimer's disease	interacts_with	disease	0.55
TGM2	interacts_with	gene	0.55
VIPR1	regulates	protein	0.50
UNC13A	regulates	gene	0.50
TBK1	regulates	gene	0.50
TDP-43	interacts_with	protein	0.50
RBPJL	regulates	gene	0.50
FUS	interacts_with	gene	0.50

Incoming (102)

Source	Relation	Type	Str
DNA	activates	gene	0.90
DNA	interacts_with	gene	0.85
GRN	interacts_with	gene	0.80
RNA	activates	gene	0.80
ALS	interacts_with	gene	0.75
DNA	regulates	gene	0.75
RNA	regulates	gene	0.75
PGRN	interacts_with	gene	0.70
RNA	interacts_with	gene	0.65
CHMP2B	activates	gene	0.60
LC3	activates	gene	0.60
MAP1LC3	activates	gene	0.60
PINK1	activates	gene	0.60
PTEN	activates	gene	0.60
SPHK1	activates	gene	0.60
CALCOCO2	interacts_with	gene	0.60
HTT	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
MAPT	activates	gene	0.60
FUS	interacts_with	gene	0.60
NTN3	interacts_with	gene	0.60
PTN	interacts_with	gene	0.60
SNRNP70	interacts_with	gene	0.60
HTT	regulates	gene	0.60
SOD1	interacts_with	gene	0.60
FUS	regulates	gene	0.60
NTN1	interacts_with	gene	0.60
NEAT1	interacts_with	gene	0.60
FTLD	interacts_with	gene	0.60
STING	activates	gene	0.60
DNA	inhibits	gene	0.60
ATXN2	activates	gene	0.60
ALS	regulates	gene	0.60
FIP200	activates	gene	0.60
MTORC1	activates	gene	0.60
RAN	activates	gene	0.60
RB1	activates	gene	0.60
RB1CC1	activates	gene	0.60
SMCR8	activates	gene	0.60
STX17	activates	gene	0.60
ALS	activates	gene	0.60
AR	activates	gene	0.60
ATG	activates	gene	0.60
BAG3	activates	gene	0.60
BCL2	activates	gene	0.60

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound targeting EC-II	0.968	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop optogenetic targeting PV interneurons to restore	0.959	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.955	alzheimers	Circuit-level neural dynamics in neurode
Multi-Target Hypothesis: Aβ-Induced Cholinergic Damage is Pa	0.887	-	Do β-amyloid plaques and neurofibrillary
Beta-frequency entrainment therapy targeting PV interneuron-	0.884	alzheimers	Circuit-level neural dynamics in neurode

Circadian Glymphatic Entrainment via Targeted Orexin Recepto	0.882	neurodegeneration	Perivascular spaces and glymphatic clear
Closed-loop tACS targeting EC-II parvalbumin interneurons to	0.869	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II PV interneuro	0.863	alzheimers	Circuit-level neural dynamics in neurode
J-protein co-chaperone system mediates selective autophagy t	0.831	protein-biochemistry	Do chaperones selectively recognize path
Real-time gamma-guided transcranial focused ultrasound targe	0.827	alzheimers	Circuit-level neural dynamics in neurode
GLE1-Mediated mRNA Export Defect Creates Translation-Compete	0.823	als	-
Closed-loop tACS targeting EC-II PV interneurons to suppress	0.811	alzheimers	Circuit-level neural dynamics in neurode
Targeted Butyrate Supplementation for Microglial Phenotype M	0.805	neurodegeneration	What are the mechanisms by which gut mic
Targeting the Mechanistic Link Between AQP4 Dysfunction and	0.803	neurodegeneration	Can ferroptosis inhibitors prevent BBB d
pH-Sensitive Bispecific Antibody Targeting Transferrin Recep	0.800	neurodegeneration	Blood-brain barrier antibody transport m
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.797	alzheimers	Circuit-level neural dynamics in neurode
Selective APOE4 Degradation via Proteolysis Targeting Chimer	0.795	neurodegeneration	APOE4 structural biology and therapeutic
Targeting SASP-Complement Amplification Through HIF-1α Downs	0.793	neurodegeneration	What molecular mechanism causes VCP muta
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.784	alzheimers	Circuit-level neural dynamics in neurode
TREM2-APOE4 Co-targeting — Simultaneous Correction of Lipid	0.774	alzheimers	TREM2 agonism vs antagonism in DAM micro
Targeted APOE4-to-APOE3 Base Editing Therapy	0.758	neurodegeneration	APOE4 structural biology and therapeutic
Closed-loop focused ultrasound targeting CA1 PV interneurons	0.754	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II SST interneurons to block t	0.752	alzheimers	Circuit-level neural dynamics in neurode
VHH-Fc Fusion Constructs with Separate BBB-Targeting Moiety	0.750	neurodegeneration	Blood-brain barrier antibody transport m
Closed-loop focused ultrasound targeting EC-II SST interneur	0.748	alzheimers	Circuit-level neural dynamics in neurode
Phase-Separated Organelle Targeting	0.729	neurodegeneration	Microglia-astrocyte crosstalk amplificat
Metabolic Switch Targeting for A1→A2 Repolarization	0.726	neurodegeneration	Astrocyte reactivity subtypes in neurode
TDP-43 condensation thermodynamics as a therapeutic target a	0.724	neuroscience	How can subcellular compartmentalization
Proteostasis Enhancement via APOE Chaperone Targeting	0.724	neurodegeneration	Mechanistic role of APOE in neurodegener
Cell-Type-Specific TFEB Modulation Combined with Trehalose f	0.000	proteomics	Quantitative proteomics of the aging syn

Mentioning Analyses (13)

Scientific analyses that reference this entity

Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evalua

neurodegeneration | 2026-04-28 | 7 hypotheses Top: 0.662

Methodology challenge: notebook 'Mitochondrial transfer between neurons and glia

neurodegeneration | 2026-04-28 | 3 hypotheses Top: 0.604

Methodology challenge: notebook 'Mitochondrial transfer between neurons and glia

neurodegeneration | 2026-04-27 | 3 hypotheses Top: 0.604

Methodology challenge: notebook 'Astrocyte reactivity subtypes in neurodegenerat

neurodegeneration | 2026-04-27 | 3 hypotheses Top: 0.604

Does APOE4 drive tau propagation

neurodegeneration | 2026-04-16 | 0 hypotheses

Experiments (12)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Plant-based dietary patterns and Alzheimer's disease risk in multiethn	clinical	Alzheimer's disease and relate	0.950	0.00	human patients	proposed	N/A
CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs AD with Co	clinical	Alzheimer's Disease	0.900	0.50	aortic endothelial cells	proposed	$6,550,000
tFUS Targeting EC-II SST Interneurons Restores Hippocampal-Prefrontal	in_vivo	Alzheimer's disease	0.744	0.48	hAPP-J20 mice (n=10/group x 3	abandoned	$110,000
s:** - Test tau spreading in AQP4 knockout vs wild-type mice with PSP/	falsification	Neurodegeneration	0.400	0.50	mouse	proposed	$260,000
Circadian-Vascular-Metabolic Syndrome (CVMS) Intervention Trial	clinical	Neurodegeneration	0.400	0.50	human	proposed	$3,900,000
DLB Cognitive Fluctuation Mechanism Experiment	clinical	Neurodegeneration	0.400	0.50	human	proposed	$6,550,000
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Non-Motor Symptom Progression in Parkinson's Disease — Mechanisms and	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
NPH Glymphatic System Interaction Experiment	clinical	Neurodegeneration	0.400	0.50	human	proposed	$5,460,000
Sleep and Circadian Dysfunction as Driver of Neurodegeneration	clinical	Neurodegeneration	0.400	0.50	human	proposed	$5,460,000
Sleep Disruption and Alzheimer's Disease — mechanism and intervention	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Sleep and Respiratory Network Interaction in ALS — Experiment Design	clinical	ALS	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Combined effects of HCRTR1/2 gene variants and non-genetic factors on sleep-wake [PMID:40439868]	Zheng Z, Xue F, Wang H, Gu Q, Hu R, Li X	Pharmacol Rep	2025	1
Genetic determinants of daytime napping and effects on cardiometabolic health. [PMID:33568662]	Dashti HS, Daghlas I, Lane JM, Huang Y,	Nat Commun	2021	1
Hypocretin/Orexin Receptor Pharmacology and Sleep Phases. [PMID:34052813]	Sun Y, Tisdale RK, Kilduff TS	Front Neurol Neurosci	2021	1
Sleep drives metabolite clearance from the adult brain. [PMID:24136970]	Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th	Science	2013	1
Signal transduction, dimerization, and therapeutic targeting of Orexin and recep [PMID:41383480]	Zhang S, Wang P, Ji B, Shao Y, Hou S et	Front Pharmacol	2025	0
Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Al [PMID:40514243]	Jiang Y, Sachdeva K, Goulbourne CN, Berg	The Journal of neuroscience :	2025	0
Targeting Neural Oscillations for Cognitive Enhancement in Alzheimer’s Disease [PMID:40142358]	Federica Palacino, P. Manganotti, A. Ben	{'name': 'Medicina', 'volume':	2025	0
Bioinformatic analysis of neuropeptide related genes in patients diagnosed with [PMID:39437604]	Yay F, Ayan D	Comput Biol Med	2024	0
Effects of Paradoxical Sleep Deprivation on MCH and Hypocretin Systems. [PMID:39698172]	Agamme ALDA, Tufik S, Torterolo P, D'Alm	Sleep science (Sao Paulo, Braz	2024	0
P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667]	Zhang D, Zhang W, Ming C, Gao X, Yuan H,	Neuron	2024	0
The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117]	Balusu S, De Strooper B	Acta neuropathologica	2024	0
Blast Exposure Induces Acute Alterations in Circadian Clock Genes in the Hypotha [PMID:41127649]	Govindarajulu M, Patel MY, Krishnan J, L	Neurotrauma reports	2023	0
Contextual generalization of social stress learning is modulated by orexin recep [PMID:35724928]	Yaeger JDW, Krupp KT, Summers TR, Summer	Neuropharmacology	2022	0
Evaluation of the α-casein (CSN1S1) locus as a potential target for a site-speci [PMID:35568783]	["Smirnov A", "Kontsevaya G", "Shnaider	Scientific reports	2022	0
Outcomes of a telemedicine bowel management program during COVID-19. [PMID:34686377]	["Knaus M", "Ahmad H", "Metzger G", "Bey	Journal of pediatric surgery	2022	0
Chemical genetic activation of the cholinergic basal forebrain hippocampal circu [PMID:35418161]	Weilin Liu, Jianhong Li, Minguang Yang	{'name': "Alzheimer's Research	2022	0
Sleep interventions in AD trials show inconsistent cognitive benefits, possibly [PMID:33661831]	Unknown	Sleep Medicine Reviews	2021	0
Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890]	Burillo J, Marqués P, Jiménez B, Gonzále	Cells	2021	0
Impact of 40 Hz Transcranial Alternating Current Stimulation on Cerebral Tau Bur [PMID:34958021]	M. Dhaynaut, G. Sprugnoli, D. Cappon	{'name': "Journal of Alzheimer	2021	0
Machine learning for clinical decision support in infectious diseases: a narrati [PMID:31539636]	["Peiffer-Smadja N", "Rawson T", "Ahmad	Clinical microbiology and infe	2020	0

Debates (19)

Multi-agent debates referencing this entity

Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evalua

closed · Rounds: 4 · Score: 0.76 · 2026-04-28

Methodology challenge: notebook 'Astrocyte reactivity subtypes in neurodegenerat

closed · Rounds: 4 · Score: 0.64 · 2026-04-28

Methodology challenge: notebook 'Mitochondrial transfer between neurons and glia

closed · Rounds: 4 · Score: 0.64 · 2026-04-28

Methodology challenge: notebook 'Mitochondrial transfer between neurons and glia

closed · Rounds: 4 · Score: 0.64 · 2026-04-28

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

closed · Rounds: 4 · Score: 0.50 · 2026-04-21

Investigate mechanisms of epigenetic reprogramming in aging neurons [TARGET_ART

closed · Rounds: 0 · Score: 0.50 · 2026-04-21

Investigate mechanisms of epigenetic reprogramming in aging neurons

closed · Rounds: 0 · Score: 0.56 · 2026-04-21

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

closed · Rounds: 0 · Score: 0.48 · 2026-04-21

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

closed · Rounds: 0 · Score: 0.51 · 2026-04-21

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

closed · Rounds: 4 · Score: 0.73 · 2026-04-21

Related Research

Hypotheses and analyses mentioning TAR in their description or question text

Circadian Glymphatic Entrainment via Targeted Orexin Receptor Modulation

Score: 0.882 · neurodegeneration · 2026-04-02

## Mechanistic Overview This therapeutic hypothesis proposes leveraging orexin (hypocretin) receptor modulation to enha

Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhyth

Score: 0.869 · alzheimers · 2026-04-05

## Mechanistic Overview Parvalbumin-positive (PV+) fast-spiking interneurons in entorhinal cortex layers II–III generat

Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-

Score: 0.863 · alzheimers · 2026-04-07

## Mechanistic Overview Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-gamma coupling a

J-protein co-chaperone system mediates selective autophagy targeting of pathogen

Score: 0.831 · protein-biochemistry · 2026-04-28

**Molecular Mechanism and Rationale** The J-protein co-chaperone system functions as a critical autophagy adapter mecha

Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST inter

Score: 0.827 · alzheimers · 2026-04-07

## Mechanistic Overview Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST interneurons to resto

Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and bl

Score: 0.811 · alzheimers · 2026-04-05

## Mechanistic Overview Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and block tau propagat

Targeted Butyrate Supplementation for Microglial Phenotype Modulation

Score: 0.805 · neurodegeneration · 2026-04-02

## Mechanistic Overview Targeted Butyrate Supplementation for Microglial Phenotype Modulation starts from the claim that

Targeting the Mechanistic Link Between AQP4 Dysfunction and Ferroptosis Prevents

Score: 0.803 · neurodegeneration · 2026-04-17

## Mechanistic Overview Targeting the Mechanistic Link Between AQP4 Dysfunction and Ferroptosis Prevents Both Cytotoxic

pH-Sensitive Bispecific Antibody Targeting Transferrin Receptor for CNS Delivery

Score: 0.800 · neurodegeneration · 2026-04-22

## Mechanistic Overview pH-Sensitive Bispecific Antibody Targeting Transferrin Receptor for CNS Delivery starts from the

Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with r

Score: 0.797 · alzheimers · 2026-04-07

## Mechanistic Overview Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with real-time gamma f

Selective APOE4 Degradation via Proteolysis Targeting Chimeras (PROTACs)

Score: 0.795 · neurodegeneration · 2026-04-02

## Mechanistic Overview Selective APOE4 Degradation via Proteolysis Targeting Chimeras (PROTACs) starts from the claim t

Targeting SASP-Complement Amplification Through HIF-1α Downstream Effectors

Score: 0.793 · neurodegeneration · 2026-04-14

## Mechanistic Overview Targeting SASP-Complement Amplification Through HIF-1α Downstream Effectors starts from the clai

Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activa

Score: 0.784 · alzheimers · 2026-04-05

## Mechanistic Overview Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activate AMPK-autophag

TREM2-APOE4 Co-targeting — Simultaneous Correction of Lipid Sensing and Clearanc

Score: 0.774 · alzheimers · 2026-04-04

## Mechanistic Overview TREM2-APOE4 Co-targeting — Simultaneous Correction of Lipid Sensing and Clearance Deficits start

TAR

Understanding Entity Pages

Summary

Wiki Pages (13)

TARDBP Protein (TDP-43)

TAR DNA-Binding Protein 43 (TDP-43)

TDP-43 (TAR DNA-Binding Protein 43) - Biomarker

Synaptic Therapy Alzheimer's Research Trial (START): A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of CT1812 in Early Alzheimer's Disease (NCT05531656)

SL-START - SubLingual Apomorphine Schemes of TitrAtion in Real-world Treatment

TARS1 — Threonyl-tRNA Synthetase 1

TARDBP — TAR DNA Binding Protein 43

CACNG6 (TARP γ8)

TARDBP/TDP-43 Protein

ALS10 - Amyotrophic Lateral Sclerosis 10 (TARDBP)

TARDBP Mutations in Amyotrophic Lateral Sclerosis

CACNG4 - TARP Gamma-4 Calcium Channel Subunit

STAR — Steroidogenic Acute Regulatory Protein

Pathway Diagram

Outgoing (59)

Incoming (102)

Targeting Hypotheses (30)

Mentioning Analyses (13)

Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evalua

Methodology challenge: notebook 'Mitochondrial transfer between neurons and glia

Methodology challenge: notebook 'Mitochondrial transfer between neurons and glia

Methodology challenge: notebook 'Astrocyte reactivity subtypes in neurodegenerat

Does APOE4 drive tau propagation

Does APOE4 drive tau propagation

test debate

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons

Experiments (12)

Related Papers (20)

Debates (19)

Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evalua

Methodology challenge: notebook 'Astrocyte reactivity subtypes in neurodegenerat

Methodology challenge: notebook 'Mitochondrial transfer between neurons and glia

Methodology challenge: notebook 'Mitochondrial transfer between neurons and glia

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons [TARGET_ART

Investigate mechanisms of epigenetic reprogramming in aging neurons

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Related Research

Circadian Glymphatic Entrainment via Targeted Orexin Receptor Modulation

Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhyth

Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-

J-protein co-chaperone system mediates selective autophagy targeting of pathogen

Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST inter

Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and bl

Targeted Butyrate Supplementation for Microglial Phenotype Modulation

Targeting the Mechanistic Link Between AQP4 Dysfunction and Ferroptosis Prevents

pH-Sensitive Bispecific Antibody Targeting Transferrin Receptor for CNS Delivery

Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with r

Selective APOE4 Degradation via Proteolysis Targeting Chimeras (PROTACs)

Targeting SASP-Complement Amplification Through HIF-1α Downstream Effectors

Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activa

TREM2-APOE4 Co-targeting — Simultaneous Correction of Lipid Sensing and Clearanc