protein

TAR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TAR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

163Connections

30Hypotheses

30Analyses

50Outgoing

50Incoming

Summary

Page for TAR DNA-Binding Protein 43 (TDP-43)

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🔬 Protein Info

Gene Symbol	TAR
Aliases	TDP-43
Chromosome	1p36.22
Molecular Weight	44.7 kDa
Amino Acids	414 aa
Pathways	oxidative stress response, UNFOLDED PROTEIN RESPONSE, UBIQUITIN-PROTEASOME
GeneCards	TAR
Human Protein Atlas	TAR
Associated Diseases	ALS, Alzheimer, dementia, frontotemporal, neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	TGM2, TARDBP, TFEB, TPP1, TREH, TBK1
KG Connections	163 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    TAR["<b>TAR</b>"]
    TDP_43(["TDP-43"])
    TAR -->|"interacts_with"| TDP_43
    WAS(["WAS"])
    TAR -->|"co_discussed"| WAS
    FUS(["FUS"])
    TAR -->|"interacts_with"| FUS
    RNA(["RNA"])
    TAR -->|"regulates"| RNA
    GENES(["GENES"])
    TAR -->|"regulates"| GENES
    TBK1(["TBK1"])
    TAR -->|"regulates"| TBK1
    DNA(["DNA"])
    DNA -->|"co_discussed"| TAR
    NEAT1(["NEAT1"])
    NEAT1 -->|"co_discussed"| TAR
    NEURON(["NEURON"])
    NEURON -->|"co_discussed"| TAR
    style TAR fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (60)

Target	Relation	Type	Str
oxidative stress response	participates_in	pathway	0.85
neurodegeneration	interacts_with	disease	0.85
TARDBP	regulates	gene	0.75
TDP-43	regulates	gene	0.75
frontotemporal dementia	interacts_with	disease	0.75
ALS	interacts_with	disease	0.75
ALS	associated_with	disease	0.60
neurodegeneration	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
dementia	associated_with	disease	0.60
frontotemporal	associated_with	disease	0.60
TARDBP	activates	gene	0.60
TFEB	activates	gene	0.60
TPP1	activates	gene	0.60
TREH	activates	gene	0.60
Parkinson's disease	activates	disease	0.60
neurodegeneration	activates	disease	0.60
ALS	activates	disease	0.60
Huntington's disease	activates	disease	0.60
autophagy pathway	participates_in	pathway	0.60
TBK1	activates	gene	0.60
VCP	activates	gene	0.60
frontotemporal dementia	activates	disease	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
TAX1BP1	interacts_with	gene	0.60
Huntington's disease	interacts_with	disease	0.60
ULK1	activates	gene	0.60
WDR41	activates	gene	0.60
TDP43	regulates	gene	0.60
TDP43	interacts_with	gene	0.60
Alzheimer's disease	activates	disease	0.60
neurodegeneration	regulates	disease	0.60
Notch signaling	participates_in	pathway	0.60
TMEM106B	interacts_with	gene	0.60
ALS	regulates	disease	0.60
VCP	regulates	gene	0.60
VCP	interacts_with	gene	0.60
neurons	expressed_in	cell_type	0.55
DAM microglia	expressed_in	cell_type	0.55
Alzheimer's disease	interacts_with	disease	0.55
TGM2	interacts_with	gene	0.55
TARDBP	interacts_with	gene	0.55
Parkinson's disease	interacts_with	disease	0.55
stem cells	expressed_in	cell_type	0.55
TDP-43	interacts_with	protein	0.50
WAS	co_discussed	protein	0.50
FUS	interacts_with	gene	0.50
RNA	regulates	gene	0.50
GENES	regulates	gene	0.50
TBK1	regulates	gene	0.50

Incoming (103)

Source	Relation	Type	Str
DNA	activates	gene	0.90
DNA	interacts_with	gene	0.85
RNA	activates	gene	0.80
GRN	interacts_with	gene	0.80
DNA	regulates	gene	0.75
RNA	regulates	gene	0.75
ALS	interacts_with	gene	0.75
PGRN	interacts_with	gene	0.70
RNA	interacts_with	gene	0.65
ALS	activates	gene	0.60
AR	activates	gene	0.60
ATG	activates	gene	0.60
BAG3	activates	gene	0.60
BCL2	activates	gene	0.60
BECN1	activates	gene	0.60
CTSB	activates	gene	0.60
GAPDH	activates	gene	0.60
GLA	activates	gene	0.60
HSPA8	activates	gene	0.60
HSPB8	activates	gene	0.60
LAMP1	activates	gene	0.60
LAMP2A	activates	gene	0.60
LGALS3	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
MCOLN1	activates	gene	0.60
MTOR	activates	gene	0.60
PPARGC1A	activates	gene	0.60
PPP3CB	activates	gene	0.60
SOD1	activates	gene	0.60
SQSTM1	activates	gene	0.60
STIP1	activates	gene	0.60
STUB1	activates	gene	0.60
rapamycin	targets	drug	0.60
CHMP2B	activates	gene	0.60
LC3	activates	gene	0.60
MAP1LC3	activates	gene	0.60
PINK1	activates	gene	0.60
PTEN	activates	gene	0.60
SPHK1	activates	gene	0.60
CALCOCO2	interacts_with	gene	0.60
HTT	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
AMPK	activates	gene	0.60
EIF2A	activates	gene	0.60
FIP200	activates	gene	0.60

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Multi-Target Hypothesis: Aβ-Induced Cholinergic Damage is Pa	0.700	-	Do β-amyloid plaques and neurofibrillary
Closed-loop tACS targeting EC-II SST interneurons to block t	0.697	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II SST interneur	0.697	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II PV interneurons to suppress	0.670	Alzheimer's disease	Circuit-level neural dynamics in neurode
Beta-frequency entrainment therapy targeting PV interneuron-	0.669	Alzheimer's disease	Circuit-level neural dynamics in neurode

Closed-loop tACS targeting EC-II parvalbumin interneurons to	0.660	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop optogenetic targeting PV interneurons to restore	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.625	Alzheimer's disease	Circuit-level neural dynamics in neurode
Circadian Glymphatic Entrainment via Targeted Orexin Recepto	0.623	neurodegeneration	Perivascular spaces and glymphatic clear
Closed-loop focused ultrasound targeting CA1 PV interneurons	0.614	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.612	Alzheimer's disease	Circuit-level neural dynamics in neurode
Targeting SASP-Complement Amplification Through HIF-1α Downs	0.610	neurodegeneration	What molecular mechanism causes VCP muta
DLK MAPK Pathway Inhibition to Block Tau-Induced Neurotoxici	0.609	neurodegeneration	Should microtubule-stabilizing drugs be
Selective APOE4 Degradation via Proteolysis Targeting Chimer	0.595	neurodegeneration	APOE4 structural biology and therapeutic
Closed-loop tACS targeting EC-II PV interneurons to enhance	0.578	Alzheimer's disease	Circuit-level neural dynamics in neurode
TDP-43 Cryptic Exon–Targeted ASOs to Restore Hippocampal Gam	0.577	neurodegeneration	RNA binding protein dysregulation across
Closed-loop focused ultrasound targeting EC-II PV interneuro	0.568	Alzheimer's disease	Circuit-level neural dynamics in neurode
Targeted Butyrate Supplementation for Microglial Phenotype M	0.559	neurodegeneration	What are the mechanisms by which gut mic
Optogenetic restoration of hippocampal gamma oscillations vi	0.554	Alzheimer's disease	Circuit-level neural dynamics in neurode
MFSD2A-Targeted Lysophosphatidylcholine-SPM Conjugates as CN	0.552	neuropharmacology	What determines blood-brain barrier pene
CLU-APOE-TREM2 Tripartite Axis as a Coordinate Therapeutic T	0.548	neurodegeneration	Does clusterin exacerbate or protect aga
ABCA7-TREM2 Co-Targeting for Microglial Lipid Handling	0.538	neurodegeneration	Why does the V1613M variant reduce amylo
Real-time gamma-guided transcranial focused ultrasound targe	0.538	Alzheimer's disease	Circuit-level neural dynamics in neurode
Targeted APOE4-to-APOE3 Base Editing Therapy	0.526	neurodegeneration	APOE4 structural biology and therapeutic
Phase-Separated Organelle Targeting	0.521	neurodegeneration	Microglia-astrocyte crosstalk amplificat
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In	0.515	neurodegeneration	Perivascular spaces and glymphatic clear
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.508	Alzheimer's disease	Circuit-level neural dynamics in neurode
Proteostasis Enhancement via APOE Chaperone Targeting	0.496	neurodegeneration	Mechanistic role of APOE in neurodegener
Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro	0.488	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (30)

Scientific analyses that reference this entity

Does APOE4 drive tau propagation

neurodegeneration | 2026-04-16 | 0 hypotheses

Does APOE4 drive tau propagation

neurodegeneration | 2026-04-15 | 0 hypotheses

test debate

neurodegeneration | 2026-04-15 | 0 hypotheses

How do sphingomyelin/ceramide ratios specifically regulate BACE1 clustering and

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.596

What determines the GPX4/ACSL4 balance that switches microglia from protective t

immunology | 2026-04-15 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Combined effects of HCRTR1/2 gene variants and non-genetic factors on sleep-wake [PMID:40439868]	Zheng Z, Xue F, Wang H, Gu Q, Hu R, Li X	Pharmacol Rep	2025	1
Genetic determinants of daytime napping and effects on cardiometabolic health. [PMID:33568662]	Dashti HS, Daghlas I, Lane JM, Huang Y,	Nat Commun	2021	1
Hypocretin/Orexin Receptor Pharmacology and Sleep Phases. [PMID:34052813]	Sun Y, Tisdale RK, Kilduff TS	Front Neurol Neurosci	2021	1
Sleep drives metabolite clearance from the adult brain. [PMID:24136970]	Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th	Science	2013	1
Gray matter structural and molecular signatures in Alzheimer's disease and late- [PMID:41419068]	Yang S, Wang X, Yan Y, Zhang J, Wei Y et	J Affect Disord	2026	0
Duloxetine Improves Early Clinical Outcomes Including Range of Motion, Functiona [PMID:41934361]	Han SC, Han J, Min YK, Han JW, Jeong HJ	Am J Sports Med	2026	0
External fixation versus reverse shoulder arthroplasty for proximal humerus frac [PMID:41940987]	Vadalà A, Benelli C, Suraci F, Carta B,	Arch Orthop Trauma Surg	2026	0
Modeling and simulation of conducting airways during continuous high-frequency o [PMID:41941967]	Huang X, Francis I, Gu Y, Saha SC	Respir Physiol Neurobiol	2026	0
Potential antidepressant properties of aminophylline in male mice exposed to chr [PMID:41945313]	Samante FI, Galangue CG, Avelino DC, Bel	Pharmacol Rep	2026	0
Robot-assisted immediate implant placement with the socket shield technique in t [PMID:41963213]	Wu J, Lin B, Yang S, Xu S, Li S	J Prosthet Dent	2026	0
Signal transduction, dimerization, and therapeutic targeting of Orexin and recep [PMID:41383480]	Zhang S, Wang P, Ji B, Shao Y, Hou S et	Front Pharmacol	2025	0
Fate plasticity of interneuron specification. [PMID:40264797]	Mostajo-Radji MA, Leon WRM, Breevoort A,	iScience	2025	0
Human stem cell-derived GABAergic interneuron development reveals early emergenc [PMID:40651475]	Bershteyn M, Zhou H, Fuentealba L, Chen	Neuron	2025	0
Forebrain assembloids support the development of fast-spiking human PVALB+ corti [PMID:40695284]	Walsh RM, Crabtree GW, Kalpana K, Jubier	Neuron	2025	0
Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social [PMID:40320404]	Qi C, Sima W, Mao H, Hu E, Ge J et al.	Nat Commun	2025	0
Distinct dendritic integration strategies control dynamics of inhibition in the [PMID:40592329]	Morabito A, Zerlaut Y, Dhanasobhon D, Be	Neuron	2025	0
Bioinformatic analysis of neuropeptide related genes in patients diagnosed with [PMID:39437604]	Yay F, Ayan D	Comput Biol Med	2024	0
Effects of Paradoxical Sleep Deprivation on MCH and Hypocretin Systems. [PMID:39698172]	Agamme ALDA, Tufik S, Torterolo P, D'Alm	Sleep science (Sao Paulo, Braz	2024	0
Targeting SARM1 improves autophagic stress-induced axonal neuropathy. [PMID:37561040]	Kim HR, Lee HJ, Jeon Y, Jang SY, Shin YK	Autophagy	2024	0
Integrated multimodal cell atlas of Alzheimer's disease. [PMID:39402379]	Gabitto MI, Travaglini KJ, Rachleff VM,	Nat Neurosci	2024	0

TAR

Understanding Entity Pages

Summary

Wiki Pages (20)

primary-progressive-aphasia

Frontotemporal Dementia (FTD)

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

ftd-tdp-pathology

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

Splice-Modulating Therapies for Neurodegeneration

TDP-43 Proteinopathy

RNA Metabolism Dysregulation in Alzheimer's Disease

Motor Neuron Disease (MND)

ALS-FTD Spectrum

amiloride-als

TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS)

Tunneling Nanotubes in Neurodegeneration

AMPA Receptor Neurons

RNA-Targeted Therapies in Neurodegeneration

UBQLN2 — Ubiquilin 2

PKR Pathway in Neurodegeneration

PET Imaging in Neurodegeneration

Complement System in Neurodegeneration

Pathway Diagram

Outgoing (60)

Incoming (103)

Targeting Hypotheses (30)

Mentioning Analyses (30)

Does APOE4 drive tau propagation

Does APOE4 drive tau propagation

test debate

How do sphingomyelin/ceramide ratios specifically regulate BACE1 clustering and

What determines the GPX4/ACSL4 balance that switches microglia from protective t

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

Do CXCL10-recruited CD8+ T cells provide neuroprotection or cause damage in agin

What are the physiological functions of BACE1 beyond APP processing that could c

What upstream mechanisms trigger p53 activation specifically in response to poly

What molecular mechanisms link elevated sphingomyelin synthase activity to incre

What molecular mechanisms explain how apoE promotes cerebral amyloid angiopathy

What molecular mechanisms cause iPLA2β deficiency to specifically damage mitocho

What molecular mechanisms enable Gal3 to enhance tau fibrillation upon binding t

Why does autophagy inhibition improve neuronal survival when autophagy is typica

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

Does clusterin exacerbate or protect against neuronal death in neurodegeneration

What specific molecular mechanisms link APOE4 to cholesterol dysregulation in ol

What are the molecular mechanisms by which GLP-1RAs provide neuroprotective effe

What are the specific circulating factors in exercise-conditioned plasma that me

What genetic risk factors predispose individuals to developing CTE following rep

How do ALS-associated OPTN mutations mechanistically disrupt Rab8a binding and c

What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic

What signals trigger microglia to specifically recognize and phagocytose LC axon

Why does the V1613M variant reduce amyloid pathology when ABCA7 loss-of-function

What molecular mechanisms explain how KCNJ2 inhibition mitigates TBI-induced neu

What molecular mechanisms drive neuron-to-glioma synapse formation in high-neura

Why does PGC-1α overexpression paradoxically increase MPTP toxicity despite enha

What is the molecular mechanism by which oligodendroglial MCT1 disruption causes

What molecular mechanism causes VCP mutations to trigger aberrant HIF-1α activat

Related Papers (20)